Melanotic Adamantinoma of the Mandible in a Child Aged 5 Months

Abstract

Rosenberg of Worthing referred to my Outpatient Department at Guy's Hospital a female child, aged 5 months, with a swelling of the right lower jaw. This swelling had been first noticed six weeks previously and the mother was of the opinion

A case of multicentric melanotic adamantinoma

“…Several pathological terms have been given to this tumour, among them ' melanotic adamantinoma ' (Wass, 1948). Stowens (1957), in a critical review of the literature, collected 21 cases and added 3 from his own experience.…”

Establishment and characterization of new cell lines derived from melanotic neuroectodermal tumor of infancy arising in the mandible

“…Almost 70% of the cases occur in the maxilla, while 5% occur in the mandible, 1–3 in addition to the skull bone, epididymis, skin, brain, cerebellum, uterus, ovary and mediastinum 2–5 . This tumor has been referred to by other synonyms such as congenital melanocarcinoma, 6 retinal anlage tumor, 7 melanotic epithelial odontoma, 8 melanotic and pigmented adamantinoma, 9,10 melanotic ameloblastoma, 11 retinal choriostoma and melanotic progonoma, 12 and neuroectodermal tumor of infancy, 13 indicating its controversial histopathogenesis. According to previous immunohistochemical and ultrastructural data and gene expression modes, a neural crest origin has been proposed, although its actual cell origin has not yet been determined 13–19 …”