Melanosis Coli Associated with Aloe Consumption in a Child

Shim, Jeong Ok; Lee, Seung Koo

doi:10.5223/kjpgn.2010.13.1.81

Cited by 2 publications

(4 citation statements)

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“…In China, the MC incidence has presented an increasing trend with an aging population and the changes in diet composition and living environment. The detection rate in our study has exhibited a yearly rising trend, with a younger onset age as reported before ( Shim & Lee, 2010 ). The MC incidence rate is around 10% or higher in Western nations ( Thompson & Heaton, 1980 ), whereas the reported detection rate in China is significantly lower (1.78% in this study).…”

Section: Discussionsupporting

confidence: 77%

“…Aging is an important contributor to cell apoptosis, leading to evidently weakened capability of toxin metabolism, which can indirectly increase MC detection rate in middle-aged and elderly populations considering their slower metabolism ( Devons, 2002 ). Middle-aged and elderly people are prone to constipation ( Shim & Lee, 2010 ), which causes the prolonged duration of fecal retention in the colon and thus accelerates the absorption of toxins by colonic mucosa and stimulates hyperplasia, giving rise to an increased detection rate of colonic polyps and neoplasm. These lines of evidence might partially explain why the detection rates of MC concomitant diseases are higher than those of non-MC patient due to the aging-related pathogenesis of these benign and malignant disorders, such as polyp, inflammation, cancer, and diverticula.…”

Section: Discussionmentioning

confidence: 99%

“…In 1825, MC was initially reported and described as melanin pigmentation of the colonic mucosa by Billiard, while named as MC by Virchow in 1857 ( Wittoesch, Jackman & Mc, 1958 ). Recently, the detection rate of MC has been incrementally increased along with the aging of the population, an increasing prevalence of constipation, and advances in colonoscopic diagnosis year by year ( Shim & Lee, 2010 ). MC is more common in females than in males, with gradually younger onset age ( Shim & Lee, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, the detection rate of MC has been incrementally increased along with the aging of the population, an increasing prevalence of constipation, and advances in colonoscopic diagnosis year by year ( Shim & Lee, 2010 ). MC is more common in females than in males, with gradually younger onset age ( Shim & Lee, 2010 ). Therefore, characterization of the onset age, gender, and increase in the MC’s incidence and detection rate will benefit the prevention and diagnosis of MC in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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Gender, age, and concomitant diseases of melanosis coli in China: a multicenter study of 6,090 cases

Wang

Peng

et al. 2018

PeerJ

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Backgrounds and AimsMelanosis coli (MC) is a noninflammatory, benign, and reversible colonic disorder, but its detection rates in China are unclear. We therefore aimed to analyze the epidemiological characteristics of MC in China.MethodsWe assessed the detection rates, associated factors and concomitant diseases of MC in the patients who underwent colonoscopy at eight medical centers across five regions of China between January 2006 and October 2016. All data were procured from the electronic database established at each participating institutions.ResultsAmong the 342,922 included cases, MC was detected in 6,090 cases (detection rate = 1.78%, 95% confidence interval, 1.73%–1.82%) at a mean age of 60 years. The detection rate gradually increased yearly, and along with the increasing age regardless of gender, while a rapid increase presented in the patients ≥60 years of age (0.58% for ≤25 years, 1.22% for 25–59 years, and 3.19% for ≥60 years). The detection rate was higher in females than in males; however, the rate of per-year increase was higher in males than in females at age of ≥60 years, which was 1.85-fold of that in females. Among cancer, polyp, inflammation, and diverticula, polyp was the most common concomitant disease of MC and identified in 41.72% of MC patients.ConclusionsMC detection rates were increased annually and elevated in older patients, particularly in male patients. Males in the elderly population of ≥60 years were most likely to have MC. Colonic polyp is the most common concomitant disease of MC.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%