Mélanome malin uvéal, manifestation de la maladie de Recklinghausen

Cernéa, P; Dobrescu, G

doi:10.1159/000306806

Cited by 8 publications

(1 citation statement)

References 2 publications

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“…The relation between the ciliary nerves and malignant melanomas has been pointed out by several authors (6,8,12,16,19,20,26,31,32) and can easily be confirmed in routine histopathological studies of eyes with malignant melanomas. Vogel found a ciliary nerve at the base of the tumour in 17 out of 20 cases (31).…”

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confidence: 77%

The neural crest origin of uveal melanomas

Arnesen

1985

Int Ophthalmol

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On the basis of two cases the relation between 'neurogenic' tumours (neurinomas, neurilemmomas, Schwannomas, neurofibromas) and malignant melanomas of the uvea is discussed with emphasis on the close association of both groups of neoplasms with the ciliary nerves. The great histopathological diversity between different cases of melanoma as well as within individual cases is also pointed out. On histological and cytological criteria it may be difficult to differentiate between the 'neurogenic' tumours and the highly differentiated, spindle cell variants of the melanomas. Since all these tumours are derived from the neural crest, they might be grouped under one common heading. It is postulated that 'neurogenic' tumours have been overdiagnosed to the disadvantage of the highly differentiated spindle cell melanomas.

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Section: Commentsmentioning

confidence: 77%

The neural crest origin of uveal melanomas

Arnesen

1985

Int Ophthalmol

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Uveal malignant melanoma and von recklinghausen's neurofibromatosis

Specht

Smith

1988

Cancer

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A case of uveal malignant melanoma with extensive spread to the central nervous system occurring in a 63-year-old woman with peripheral-type von Recklinghausen's neurofibromatosis was studied by light microscopy. The tumor histologically consisted of large, loosely coherent epithelioid cells with abundant eosinophilic cytoplasm and large, irregular nuclei with prominent nucleoli. The tumor cells contained variable amounts of melanin pigment and exhibited positive immunohistochemical staining for S-100 protein and neuron-specific enolase. A review of the literature disclosed only ten previous cases of uveal malignant melanoma associated with von Recklinghausen's neurofibromatosis. A predominance of women and of the peripheral variant of von Recklinghausen's neurofibromatosis was noticed in the cases reported.

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Neurofibromatosis or von Recklinghausen’s disease

Laey

Hanssens

1990

Vascular Tumors and Malformations of the Ocular Fundus

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Mélanome malin uvéal, manifestation de la maladie de Recklinghausen

Cited by 8 publications

References 2 publications

The neural crest origin of uveal melanomas

The neural crest origin of uveal melanomas

Uveal malignant melanoma and von recklinghausen's neurofibromatosis

Neurofibromatosis or von Recklinghausen’s disease

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