“…This phenomenon can manifest as purely cartilaginous differentiation, as exemplified by our case, or as a composite of cartilaginous and osteoid elements, known as osteocartilaginous differentiation. When present in melanoma, a cartilaginous component generally exhibits increased cellularity, cytological atypia, and/or mitotic activity, supporting transdifferentiation into chondrosarcoma, rather than a metaplastic change to benign cartilage 4–6,8,10–12,15,16,18,20–22 . These melanomas typically occur in older patients without a clear sex predilection.…”