Melanoma with osseous or chondroid differentiation: a report of eight cases including SATB2 expression and mutation analysis

Gallagher, Stuart J.; Bailey, Teresa A.; Rawson, Robert V.; Mahar, Annabelle; Thompson, John F.; Long, Georgina V.; Wilmott, James S.; Scolyer, Richard A.

doi:10.1016/j.pathol.2021.02.012

Cited by 8 publications

(16 citation statements)

References 26 publications

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“…Primary melanoma as well as metastatic melanoma rarely exhibit chondroid differentiation [12]. In our first case, we describe a melanoma mimicking a mesenchymal chondrosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Melanoma cell plasticity poses diagnostic challenges: a case series

Mennens¹,

Herck²,

Sciot³

et al. 2022

Melanoma Research

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Phenotype switching is an emerging concept in melanoma research and deals with the cancer cell plasticity. In this paper, we present five cases of patients with metastatic malignant melanoma where the tumor underwent dramatic morphological and immunohistochemical changes thereby mimicking other types of malignancies. The diagnosis of melanoma in all these cases was based on the mutational profile of the tumor assessed by next-generation sequencing compared to the primary lesion or local regional lymph nodes. These cases highlight the importance of thorough diagnostic measures in patients with metastatic melanoma who show progressive disease and where basic pathological assessment shows a diagnostic discrepancy.

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“…Primary melanoma as well as metastatic melanoma rarely exhibit chondroid differentiation [12]. In our first case, we describe a melanoma mimicking a mesenchymal chondrosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Melanoma cell plasticity poses diagnostic challenges: a case series

Mennens¹,

Herck²,

Sciot³

et al. 2022

Melanoma Research

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“…A subset of melanoma, so-called "dedifferentiated melanoma," shows a complete lack of melanocytic immunohistochemical marker expression (including S-100 protein) and can be particularly difficult to diagnose [62][63][64]. Furthermore, a subset of melanoma undergoes transdifferentiation characterized by formation of heterologous elements, such as rhabdomyoblasts (with expression of desmin, myoD1, and myogenin) indicative of rhabdomyosarcomatous differentiation [65][66][67], malignant cartilage indicative of chondrosarcomatous differentiation, and malignant bone indicative of osteosarcomatous differentiation [68][69][70][71]. In samples with only the heterologous elements, transdifferentiated melanomas can be easily confused with primary rhabdomyosarcomas, chondrosarcomas, and osteosarcomas.…”

Section: Metastatic Melanomamentioning

confidence: 99%

Spindle cell tumors of the pleura and the peritoneum: pathologic diagnosis and updates

Boyraz

Hung

2022

APMIS

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A diverse group of both benign and malignant spindle cell tumors can involve the pleura or the peritoneum. Due to their rarity and overlapping morphologic features, these tumors can pose considerable diagnostic difficulty in surgical pathology. As these tumors differ in their prognosis and clinical management, their correct pathologic diagnosis is critical. In addition to histologic assessment, select immunohistochemical and molecular tools can aid the distinction among these tumors. In this review, we consider some of the major histologic differential diagnosis of spindle cell tumors involving these serosal membranes. This list of tumors includes solitary fibrous tumor, inflammatory myofibroblastic tumor, desmoid fibromatosis, synovial sarcoma, sarcomatoid carcinoma, spindle cell melanoma, dedifferentiated liposarcoma, epithelioid hemangioendothelioma, and sarcomatoid mesothelioma. We describe their salient clinicopathologic and genetic findings, with a review on some of the recent discoveries on their molecular pathogenesis.

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“…This is partly due to their rarity and broad biologic spectrum. [1][2][3][4] Correct classification is critical because the differential diagnosis includes highly malignant neoplasms and treatment varies significantly. Myxochondroid metaplasia of the plantar foot, which has been rarely reported in the English literature, enters this differential diagnosis because it usually presents in the dermis and superficial subcutis.…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Myxochondroid Metaplasia of the Plantar Foot With Review of Histopathological Mimics

Alomari

Warnock²,

Cummings³

2022

The American Journal of Dermatopathology

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:Chondromyxoid metaplasia can rarely lead to the formation of a distinctive tumor-like proliferation in the plantar foot. This is thought to represent a reactive or reparative process, possibly due to chronic trauma. For the unwary dermatopathologist, this could represent a diagnostic challenge. Herein, we review the clinical, histopathological, and molecular presentation of an athletic 17-year-old boy with a soft tissue mass arising in the right plantar foot. Microscopic examination showed a relatively circumscribed proliferation of spindle cells with abundant chondromyxoid stroma, hyalinization, and diffuse ERG reactivity. We also review characteristics of this entity that help differentiate it from clinical and histopathologic mimics and postulate possible links with soft tissue chondromas and immature chondroid choristoma.

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Melanoma with osseous or chondroid differentiation: a report of eight cases including SATB2 expression and mutation analysis

Cited by 8 publications

References 26 publications

Melanoma cell plasticity poses diagnostic challenges: a case series

Melanoma cell plasticity poses diagnostic challenges: a case series

Spindle cell tumors of the pleura and the peritoneum: pathologic diagnosis and updates

A Rare Case of Myxochondroid Metaplasia of the Plantar Foot With Review of Histopathological Mimics

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