Melanoma Prevention

Bastuji‐Garin, Sylvie; Grob, Jean-Jacques; Grognard, C.; Grosjean, Flora; Guillaume, J

doi:10.1001/archderm.135.8.936

Cited by 44 publications

(7 citation statements)

References 26 publications

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“…In many epidemiological surveys in other countries (France, England, Australia and USA), emphasis was put on questioning the children themselves [3, 4, 5, 6, 8, 10]or their parents [2, 3, 4, 7, 11]. In an interesting study by Robinson and Rademaker [7]in the USA, observers watched families at beaches to see sunscreen application usage and this was followed by a personal interview which assured concordance.…”

Section: Discussionmentioning

confidence: 99%

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Use of Sunscreens in Families Living in Switzerland

Berret¹,

Liardet²,

Scaletta³

et al. 2002

Dermatology

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Background: The hazards due to sun exposure are well known. Many recent studies have emphasized the protection against the harmful effects of the sun by the use of sunscreens and, moreover, by staying in the shade and wearing long-sleeved shirts, hats and sunglasses. Switzerland has one of the highest rates of skin cancer induction in Europe and the incidence of melanoma in Switzerland is constantly increasing with an incidence of 10–12/100,000 inhabitants/year. Interestingly, some studies have evoked the possibility that sunscreen use can increase the risk of melanoma by increasing overall sun exposure. Objective and Methods: In this context, the aim of our study was to estimate the amount of sun exposure of children, and their parents, living in Switzerland and to give a description of how they protect themselves against sun irradiation. Questionnaires were provided to pediatricians in every state (canton) in Switzerland and were given to families coming for consultation. Results: A total of 328 forms including 1,285 individuals were returned from most of the cantons in Switzerland. The majority of the Swiss families had 2 children under 16 years of age with middle-aged parents (30–45 years) and a central European skin type (light skin of type II–III, brown or blue eyes, and brown to blond hair). An important sun exposure was noted even though the population seems to be conscious of the associated dangers. Sunscreens were the first-line defense against sun exposure with clothing and shielding oneself from the sun not being highly used. Moreover, sunscreens tended to be misused with most people applying them at the beach or swimming pool (instead of 15 min before exposure) and few applications throughout the day. Conclusions: Prevention should imperatively be emphasized for lower overall sun exposure as sunscreens are primarily used at the beach and not in routine daily exposure. In addition, it is agreed that prevention campaigns would be better directed towards children because up to 80% of detrimental sun exposure occurs during childhood.

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Section: Discussionmentioning

confidence: 99%

“…There have been many prevention campaigns particularly in the USA and Australia emphasizing the protection against the harmful effects of the sun by the use of sunscreens and, moreover, by staying in the shade and wearing long-sleeved shirts, hats and sunglasses [2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12]. …”

Section: Introductionmentioning

confidence: 99%

Use of Sunscreens in Families Living in Switzerland

Berret¹,

Liardet²,

Scaletta³

et al. 2002

Dermatology

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“…There is also evidence that children may induce modifications of their parents’ behavior in terms of sun exposure as seen in an educational campaign in French primary schools [23]. Another innovative approach has been the training of mothers of newborns [24].…”

Section: Discussionmentioning

confidence: 99%

Prevention Campaign against Skin Cancer

Heinzerling

Dummer²,

Panizzon³

et al. 2002

Dermatology

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Background: The melanoma incidence has increased over recent decades. Educational campaigns aim to encourage protection from the sun and early detection of melanoma. Methods: During a campaign in Switzerland, information on risk factors, sun protection and melanoma prevention was distributed. 10,987 people completed a questionnaire regarding risk factors, and 2,746 people were examined by a dermatologist. Results: Men had a higher risk as assessed by skin type, ultraviolet exposure, family history, number of moles and sunburns during childhood. Changes in moles were reported significantly more often by people with: (1) a positive family history (p < 0.0001); (2) multiple moles (p < 0.0001), and (3) sunburns during childhood (p < 0.0001). A precancerous or cancerous condition was suspected in 16% of individuals examined. Conclusion: Early detection of melanoma can be achieved by this type of campaign. Primary prevention is a long-term approach and educational efforts targeting risk groups must be continued.

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“…Epidemiological studies have revealed that BP is significantly associated with neurological disorders, especially dementia, Parkinson disease, multiple sclerosis and cerebrovascular diseases (121)(122)(123)(124)(125)(126)(127)(128)(129)(130)(131)(132)(133)(134)(135)(136)(137)(138)(139)(140) [for a review, see (141)]. Furthermore, patients with neurological diseases appear to be at increased risk for subsequently developing BP.…”

Section: Neurological Diseases Associated With Bullous Pemphigoidmentioning

confidence: 99%

One gene but different proteins and diseases: the complexity of dystonin and bullous pemphigoid antigen 1

Künzli

Favre

Chofflon³

et al. 2015

Experimental Dermatology

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Since the immunochemical identification of the bullous pemphigoid antigen 230 (BP230) as one of the major target autoantigens of bullous pemphigoid (BP) in 1981, our understanding of this protein has significantly increased. Cloning of its gene, development and characterization of animal models with engineered gene mutations or spontaneous mouse mutations have revealed an unexpected complexity of the gene encoding BP230. The latter, now called dystonin (DST), is composed of at least 100 exons and gives rise to three major isoforms, an epithelial, a neuronal and a muscular isoform, named BPAG1e (corresponding to the original BP230), BPAG1a and BPAG1b, respectively. The various BPAG1 isoforms play a key role in fundamental processes, such as cell adhesion, cytoskeleton organization, and cell migration. Genetic defects of BPAG1 isoforms are the culprits of epidermolysis bullosa and complex, devastating neurological diseases. In this review, we summarize recent advances of our knowledge about several BPAG1 isoforms, their role in various biological processes and in human diseases.

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Melanoma Prevention

Cited by 44 publications

References 26 publications

Use of Sunscreens in Families Living in Switzerland

Use of Sunscreens in Families Living in Switzerland

Prevention Campaign against Skin Cancer

One gene but different proteins and diseases: the complexity of dystonin and bullous pemphigoid antigen 1

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