Melanoma on chronically sun-damaged skin: Lentigo maligna and desmoplastic melanoma

<p>Lentigo Maligna: Clinical Presentation and Appropriate Management</p>

“…In addition, gain-or loss-of function mutations such as CCND1, MITF and TP53 have also been implicated in melanomas on sun-damaged skin. 18 LM represents a challenging entity not only regarding the diagnosis but also regarding the management. Diagnostic criteria are not well established, and there is an overlap of clinical, dermoscopic and pathological features with other benign pigmented skin lesions such as lentigines, pigmented actinic keratoses and macular seborrheic keratoses.…”

Cells to Surgery Quiz: October 2019

“…It is important that solar lentigo be differentiated from lentigo maligna, also referred to as melanoma in situ, in the setting of sun-damaged skin. If a lentigo contains variegated pigmentation or changes, then a biopsy should be performed to rule out a malignancy (DeWane et al, 2019;Elgart, 2001). Solar lentigos can be limited through strategies to decrease UV exposure (sun avoidance, protective clothing, and sunscreen).…”

Frequency of somatic mutations in head and neck melanoma: A single‐institution experience

“…Lentigo maligna melanoma (LMM) is thought to be the most common histopathologic subtype of melanoma in head and neck area, followed by superficial spreading melanomas (SSM), nodular melanomas (NM), and less frequently desmoplastic subtypes of cutaneous melanoma. Somatic mutations such as BRAF, NRAS, and KIT gene mutations have been identified in several melanoma subtypes correlating mutational status of the tumor to the site of tumor location, to the chronic or intermittent UV exposure, and to the biologic behavior (DeWane, Kelsey, Oliviero, Rabinovitz, & Grant-Kels, 2019;Gutiérrez-Castañeda, Nova, & Tovar-Parra, 2019;Shoushtari, 2019).…”

“…Desmoplastic melanoma is rare, accounting for approximately 1% of all melanoma cases (DeWane et al, 2019). It occurs in chronically sun-damaged skin, and in 51% of cases, it affects the head and neck region (DeWane et al, 2019).…”