Melanoma of the oral mucosa with cerebral metastasis: a clinical case

Martínez, Efraín Álvarez; Camacho-Alonso, Fabio; Siles, Mariano Sánchez; Jornet, Pía López

doi:10.1016/j.ooe.2004.10.003

Cited by 12 publications

(11 citation statements)

References 18 publications

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“…OMM is a rare neoplasm with the palate and maxillary gingiva as the most common sites, where 80% of all oral melanomas are reported. 3,6 Most cases of oral melanoma occur between the ages of forth and seven decades and some reports have demonstrated a male preponderance. 7 The exact etiology of OMM is unknown; however, tobacco use, chronic irritation from ill-fitting dentures, ingested and inhaled environmental carcinogens at a high internal body temperature, have been proposed to play some role, but this has not been confirmed.…”

Section: Discussionmentioning

confidence: 99%

Oral Malignant Melanoma of the Maxilla: A Case Report

Rattana-arpha¹,

Klanrit²,

Cheusirithavorn³

2015

bkkmedj

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Rattana-arpha P, DDS, FRCDT Oral Malignant Melanoma of the Maxilla: A Case Report M alignant melanoma is a neoplasm of melanocytes, which originates from neuroectodermal cells. 1,2 Approximately 1% of all melanomas occur in the oral mucosa and of these, 0.5% are responsible for all malignancies arising in the oral cavity. 3,4 OMM and other mucosal malignant melanomas are considered more aggressive than cutaneous malignant melanomas with high rates of recurrence and death. 2,5 Case Report An 84-year-old Thai male presented with an enlarged, swollen gingiva on the anterior left maxilla with mild pain lasting eight weeks from the lower occluded teeth. The patient reported that the upper left lateral incisor was fractured due to large dental caries two months earlier, followed by soft tissue arising from the upper left lateral incisor to the upper second premolar tooth. The patient's past medical history was myocardial infarction, hypertension and chronic kidney disease for 10 years. The patient had taken aspirin (81 mg/d), nifedipine (40 mg/d), metoprolol (100 mg/d) and plavix (75 mg/d). His social history included occasional social alcohol use and smoking for many years.

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Section: Discussionmentioning

confidence: 99%

Oral Malignant Melanoma of the Maxilla: A Case Report

Rattana-arpha¹,

Klanrit²,

Cheusirithavorn³

2015

bkkmedj

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“…[30] Lymphatic metastasis at the time of diagnosis seems to be a crucial prognostic factor for oral melanomas.…”

Section: Discussionmentioning

confidence: 99%

Oral malignant melanoma: A silent killer?

Padhye¹,

D'souza²

2011

J Indian Soc Periodontol

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Oral malignant melanomas are extremely rare lesions and occur commonly in the maxillary gingiva more frequently on the palate with fewer incidences in the mandibular gingiva. Though these lesions are biologically aggressive, they often go unnoticed since they are clinically asymptomatic in the early stages and usually present merely as a hyperpigmented patch on the gingival surface. These lesions if diagnosed at an early in situ stage are potentially curable and definitely have a better prognosis, but unfortunately as they are clinically asymptomatic, it results in delayed diagnosis thus making the prognosis extremely poor. This paper presents the case of a patient who visited our department with the complaint of darkened patches on the gums and his concern was purely aesthetic. There were no symptoms associated with the hyperpigmented lesions and hence the patient did not approach us earlier. When the lesions grew larger and were unsightly, the patient has seeked dental advice. Histopathologic investigation confirmed the diagnosis as ‘Oral Malignant Melanoma’. Though aggressive therapy was instilled immediately, unfortunately, the patient succumbed to death within a few months after diagnosis as the lesion was highly invasive. Due to the biologically aggressive but clinically silent nature of progression of the lesion, the importance of maintaining a high index of suspicion and early detection and diagnosis for any pigmented gingival lesions cannot be overemphasised. Diagnosis must be based on thorough detailed history and valid histologic evidence.

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“…The present lesion showed both insitu and invasive histological pattern. Special staining techniques like Fontana silver stain and the Prussian blue stain are useful in about 75% of cases and the immunocytochemical diagnosis of malignant melanoma has become the method of choice [9,10]. The demonstration of neuronal specific S-100 protein is a useful diagnostic indicator, especially if the tumor is of the amelanotic type.…”

Section: Discussionmentioning

confidence: 99%

Malignant melanoma of lingual gingiva with ipsilateral submandibular lymph node metastasis: a case report

Prasad

Chakravarthi

Devi

et al. 2009

J. Maxillofac. Oral Surg.

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Malignant melanoma is a neoplasm of epidermal melanocytes. It is one of the most biologically unpredictable and deadly of all human neoplasms. However, malignant melanoma in the oral cavity is a rare malignancy, accounting for 0.2% to 8% of all melanomas. It has a grave prognosis, with a 5 year survival of 10-20%. We present a case of malignant melanoma of lingual gingiva of left mandibular molars with ipsilateral submandibular lymph node metastasis. We performed peripheral osteotomy of primary lesion followed by modified radical neck dissection by sparing internal jugular vein and patient had received postoperative radiotherapy.

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Melanoma of the oral mucosa with cerebral metastasis: a clinical case

Cited by 12 publications

References 18 publications

Oral Malignant Melanoma of the Maxilla: A Case Report

Oral Malignant Melanoma of the Maxilla: A Case Report

Oral malignant melanoma: A silent killer?

Malignant melanoma of lingual gingiva with ipsilateral submandibular lymph node metastasis: a case report

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