Melanoma of the gallbladder

Dong, Xiang; DeMatos, Pierre; Prieto, Víctor G.; Seigler, Hilliard F.

doi:10.1002/(sici)1097-0142(19990101)85:1<32::aid-cncr5>3.0.co;2-z

Cited by 85 publications

(49 citation statements)

References 34 publications

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“…Also, the patients may present with right upper quadrant pain, weight loss, nausea, and vomiting [8, 16, 17]. In contrast to general belief, malignant melanomas of the gallbladder are not associated with gallstones and usually they are recognized incidentally during imaging scans [11]. Our patient presented with the clinical picture of acute cholecystitis unrelated to cholelithiasis, as seen in the literature.…”

Section: Discussionmentioning

confidence: 75%

“…A group of authors, primarily the authors mentioned above, advocated that the involvement of the gallbladder by malignant melanoma might be primary. They indicated the melanocytes as the source, which originate from the neural crest and migrate to the endoderm during the embryologic growth [11, 12]. According to the criteria, primary tumor must principally be solitary and arise from the mucosa.…”

Section: Discussionmentioning

confidence: 99%

“…Among the diagnostic tools, ultrasonography is the cheapest and the most rapid method. Ultrasonography generally reveals sole or multiple infiltrative polypoid lesions not showing acoustic shadow, larger than 1 cm, and attached to the gallbladder wall [11]. Doppler ultrasonography also demonstrates remarkably increased blood flow.…”

Section: Discussionmentioning

confidence: 99%

“…For the patients with localized malignant melanoma including primary malignant melanoma of the gallbladder, treatment modalities are still unclear because of insufficient number of patients. In a study with 19 patients, Dong et al achieved more than 1 year survival after surgical treatment in 2 patients with isolated malignant melanoma of the gallbladder [11]. Patient series of the researchers named Velez, Seelig, and Kohler exemplify patient series with malignant melanoma of the gallbladder including metastatic cases.…”

Section: Discussionmentioning

confidence: 99%

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Primary Malignant Melanoma of the Gallbladder: A Case Report and Review of the Literature

Haskaraca

Özsoy

Özsan

et al. 2012

Case Reports in Surgery

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Malignant melanoma is characterized by the ability of diffuse metastases. Since the first report of an isolated malignant melanoma case of the gallbladder, it is already controversial whether isolated cases are metastatic or primary tumors. A 49-year-old woman appealed to the emergency unit because of abdominal pain. Ultrasonography revealed increased thickness of the gallbladder wall and a lesion with surrounding fluid sized 12 mm without acoustic shadow, which arose from the gallbladder wall and was consistent with a polyp. Histopathologic evaluation of the surgical specimen after laparoscopic cholecystectomy revealed malign epithelial tumor consisting of atypical cells with large eosinophilic cytoplasm and dense melanin pigment within the cytoplasm of the tumor cells. As no other focus was identified as a result of the evaluation, the patient was diagnosed with primary malignant melanoma of the gallbladder. In this paper, we aimed to define our treatment modality for a case with isolated malignant melanoma of the gallbladder.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary Malignant Melanoma of the Gallbladder: A Case Report and Review of the Literature

Haskaraca

Özsoy

Özsan

et al. 2012

Case Reports in Surgery

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“…In our review of the literature, because the typical course of metastasis to the gallbladder is via hematogenous spread [3], the most commonly metastatic disease to the gallbladder was from melanoma followed by renal cell carcinoma and then breast cancer. Other cancers that have been reported, we have grouped in the miscellaneous category.…”

Section: Metastasis To the Gallbladdermentioning

confidence: 99%

Indications and recommended approach for surgical intervention of metastatic disease to the gallbladder

et al. 2010

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Metastatic disease to the gallbladder is unusual. The most common malignancy metastatic to the gallbladder is melanoma, followed by renal cell carcinoma (RCC) and breast cancer. Due to the unusual nature of the disease, there are no trials available for review. Thus, the management for these patients has been based on institutional experience and review of case series. The indications for surgical intervention for melanoma are metastatic disease discrete to the gallbladder and biliary symptoms, which are uncommon for melanoma, but might occur due to cystic duct obstruction culminating in cholecystitis. Laparoscopic cholecystectomy without a lymphadenectomy is emerging as the preferred approach for this metastatic deposit. The vast majority of patients with metastases to the gallbladder from RCC carry a good prognosis and a laparoscopic cholecystectomy should be considered. Patients with metastases to the gallbladder from the breast classically present with biliary symptoms and commonly undergo a laparoscopic cholecystectomy, which invariably demonstrates a deposit in the gallbladder from lobular breast cancer. In the present report, we review the indications for surgical intervention from various malignancies metastatic to the gallbladder and the current consensus for the laparoscopic approach from the diverse metastatic deposits to the gallbladder.

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