Melanoma Incidence Increases in the Elderly of Catalonia But Not in the Younger Population: Effect of Prevention or Consequence of Immigration?

Puig, Susana; Marcoval, Joaquim; Paradelo, Cristina; Azón-Masoliver, Antoni; Bartralot, R.; S, Bel; Bigatà, X.; Boada, Aram; Campoy, Antoni; Carrera, Cristina; Curcó, N.; Dalmau, Joan; Ferrándiz, Carlos; Ferreres,; Formigón, M; Gallardo, F. Perez; González, Alberto Durán; Just, Miquel; Llistosella, E; Martí, Rosa M.; Me, Nogues; Pedragosa, R; Ja, Pujol; Roldán–Marín, Rodrigo; Sàbat, Mireia; Salleras, M.; Ja, Smandia; Zaballos, Pedro; Plana, Estel; Malvehy, Josep

doi:10.2340/00015555-1997

Cited by 26 publications

(30 citation statements)

References 18 publications

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“…Although it is well known that Catalan and Spanish live expectancy is growing up and that there is progressively a higher proportion of population within the group at risk for having LM/LMM, in our study the mean age of LM/LMM patients remained stable during all the period. In contrast, we observed an increase in the mean age at diagnosis of the whole melanoma series . These findings point out that aging of the population is not necessarily the only explanation for the LM/LMM increasing rate observed in our study.…”

Section: Discussioncontrasting

confidence: 84%

“…As we have recently reported, SSM is the most common melanoma subtype (59.5%) in Catalonia, north‐eastern part of Spain. The aim of the present study was to describe the epidemiological trend of LM/LMM and its relation to the aging of the population studied in the same sample and period, 2000–2007.…”

Section: Introductionmentioning

confidence: 57%

“…Concerning LM/LMM alone, the mean age at diagnosis was 73 years (26–94). Mean age at diagnosis increased during the period for the whole melanoma group ( P < 0.001) but remained stable for LM/LMM (Table ). Regarding gender, 225 cases (54%) were females, whereas 190 (46%) were males.…”

Section: Resultsmentioning

confidence: 97%

“…During the 8‐year study period (2000–2007), a total of 4,999 melanoma patients were reported . Of them all, 282 (5.7%) were LM and 136 (2.7%) LMM which account as a whole for 8.4% of melanoma cases with a mean Breslow thickness of 1.29 mm for the invasive ones.…”

Section: Resultsmentioning

confidence: 99%

“…Data from a hospital‐based registry of melanoma cases diagnosed from 2000 to 2007 in Catalonia, 7 million inhabitants, were reported from 23 different hospitals, most public hospitals (with the exception of Hospital General de Catalunya). As we previously described, data were collected from the melanoma‐unit's databases when available (Hospital Clinic de Barcelona, Hospital de Bellvitge and Hospital Germans Trias i Pujol, which reported 59% of cases). For the remaining hospitals, data were retrospectively collected for the first 5‐year period and then prospectively.…”

Section: Methodsmentioning

confidence: 99%

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Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia

et al. 2018

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Background Recent epidemiological studies suggest that past data where superficial spreading melanoma was by far the most common subtype of melanoma may not reflect current patterns of sun exposure or other risk factors more involved in other subtypes of melanoma as lentigo maligna (LM) or lentigo maligna melanoma (LMM). Methods In order to measure the current situation in our country, all cases of LM and LMM diagnosed in 23 hospitals in Catalonia, from 2000 to 2007, were recorded. Results Although for the global period LM/LMM represented only 8.4% of cases, an increasing trend in this percentage was observed throughout the study period (from 6.9% [27 cases] in 2000 to 13.1% [94 cases] in 2007). Also, an increasing incidence of LM/LMM was observed, especially in chronically sun‐exposed areas (85.5% involving the head and neck region). During the 8 years of the registry, the mean Breslow thickness of LMM remained stable. However, the increase in the number of LM (in situ) cases was significantly higher than the increase of the invasive ones. Conclusions An important observation from this data is that aging of population and current sun exposure patterns could keep increasing the incidence of LM/LMM, which may become an important public healthcare problem, over the other histological subtypes. In order to establish primary or secondary preventive measures to the LM/LMM risk‐population, it is imperative to highlight the importance of chronic sun damage as a melanoma risk factor, and not only sunburn, most commonly addressed in melanoma prevention campaigns.

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Section: Discussioncontrasting

confidence: 84%

Section: Introductionmentioning

confidence: 57%

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia

et al. 2018

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High nevus counts confer a favorable prognosis in melanoma patients

Ribero

Davies

Requena

et al. 2015

Intl Journal of Cancer

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A high number of naevi is the most significant phenotypic risk factor for melanoma and is in part genetically determined. The number of naevi decreases from middle age onwards but this senescence can be delayed in melanoma patients. We investigated the effects of naevus number count on sentinel node status and melanoma survival in a large cohort of melanoma cases. Out of 2184 melanoma cases, 684 (31.3%) had a high naevus count (>50). High naevus counts were associated with favourable prognostic factors such as lower Breslow thickness, less ulceration and lower mitotic rate, despite adjustment for age. Naevus count was not predictive of sentinel node status. The crude 5- and 10-year melanoma specific survival rate was higher in melanomas cases with a high naevus count compared to those with a low naevus count (91.2% vs 86.4% and 87.2% vs 79%, respectively). The difference in survival remained significant after adjusting for all known melanoma prognostic factors (HR= 0.43, CI 0.21-0.89). The favourable prognostic value of a high naevus count was also seen within the positive sentinel node subgroup of patients (HR=0.22, CI 0.08-0.60). High naevus count is associated with a better melanoma survival, even in the subgroup of patients with positive sentinel lymph node. This suggests a different biological behaviour of melanoma tumours in patients with an excess of naevi.

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Mid‐term trends and recent birth‐cohort‐dependent changes in incidence rates of cutaneous malignant melanoma in Italy

Bucchi

Mancini

Crocetti

et al. 2020

Intl Journal of Cancer

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In Oceania, North America and north‐western Europe, after decades of increase, cutaneous malignant melanoma (CMM) rates began to stabilise or decline before 2000. Anecdotal evidence suggests that the reversal of the incidence trend is extending to southern Europe. To obtain a formal confirmation, this nationwide study from Italy investigated the incidence trends by birth cohort. Twenty‐one local cancer registries covering a population of 15 814 455 provided incidence data for primary CMM registered between 1994 and 2013. Trends in age‐standardised rates were analysed using joinpoint regression models and age‐period‐cohort models. Age‐standardised incidence showed a consistent increase throughout the period (estimated annual percent change, 3.6 [95% confidence interval, 3.2‐4.0] among men and 2.5 [2.0‐3.1] among women). This pattern was confirmed by a sensitivity analysis with removal of low‐risk populations of southern Italy. The rates, however, showed a stabilisation or a decrease in men and women aged below 35. Using the cohort of 1949—the median cohort with respect to the number of cases for both genders—as a reference, the incidence rate ratio increased for successive cohorts born until 1973 (women) and 1975 (men), and subsequently tended to decline. For the most recent cohorts in both genders, the risk of disease returned to the level of the cohort of 1949. The changes observed in the latest generations can be interpreted as the earliest manifestations of a birth‐cohort‐dependent incidence decrease. Our study adds to previous data indicating that the reversal of the long‐term upward incidence trend of CMM is extending to southern Europe.

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Melanoma Incidence Increases in the Elderly of Catalonia But Not in the Younger Population: Effect of Prevention or Consequence of Immigration?

Cited by 26 publications

References 18 publications

Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia

Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia

High nevus counts confer a favorable prognosis in melanoma patients

Mid‐term trends and recent birth‐cohort‐dependent changes in incidence rates of cutaneous malignant melanoma in Italy

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