Melanoma educates mesenchymal stromal cells towards vasculogenic mimicry

Vartanyan, A. A.; Karshieva, Saida Sh; Dombrovsky, Vladislav; Belyavsky, A. V.

doi:10.3892/ol.2016.4523

Cited by 17 publications

(16 citation statements)

References 21 publications

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“…In melanoma, the role of ADSC is also debated. Indeed, after co‐culture with melanoma cells, ADSC form capillary‐like structures (Vartanian et al., ), which could support increased tumor vascularization observed in obese melanoma patients. Using mesenchymal stem cells derived from bone marrow, an adipocyte‐rich environment, Sun et al.…”

Section: Role Of Adipose Tissue In Melanoma Progressionmentioning

confidence: 94%

Obesity and melanoma: could fat be fueling malignancy?

Clement

Lazar

Müller

et al. 2017

Pigment Cell Melanoma Res

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Summary Over the last decade, it has become increasingly clear that adipose tissue, and particularly adipocytes, contributes to tumor progression. Obesity, an ever‐increasing worldwide phenomenon, exacerbates this effect. The influence of obesity on melanoma remains poorly studied, although recent data do underline an association between the two diseases in both humans and murine models. Herein, we review the impact of obesity on melanoma incidence and progression and discuss the underlying mechanisms known to be involved. Adipose tissue favors the proliferation and aggressiveness of melanoma cells through a direct dialog, mediated by soluble factors and by exosomes, and through remodeling of the tumor microenvironment. This knowledge could, in the future, help to design new personalized therapeutic options for obese melanoma patients.

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Section: Role Of Adipose Tissue In Melanoma Progressionmentioning

confidence: 94%

Obesity and melanoma: could fat be fueling malignancy?

Clement

Lazar

Müller

et al. 2017

Pigment Cell Melanoma Res

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“…Considering the CSCs model, it has been also hypothesized that a fraction of CSCs could differentiate in cells with VM phenotype. Vartanian et al have demonstrated that melanoma cells were able to increase the vasculogenic potential of MSCs by VM. In fact, MSCs derived from adipose tissues of C57BL/6 mice in cocultured with melanoma cells formed vascular‐like network on Matrigel.…”

Section: Tumor Angiogenesis and Cscsmentioning

confidence: 99%

Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development

Papaccio

Paino²,

Regad

et al. 2017

Stem Cells Translational Medicine

251

197

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Tumors are composed of different types of cancer cells that contribute to tumor heterogeneity. Among these populations of cells, cancer stem cells (CSCs) play an important role in cancer initiation and progression. Like their stem cells counterpart, CSCs are also characterized by self‐renewal and the capacity to differentiate. A particular population of CSCs is constituted by mesenchymal stem cells (MSCs) that differentiate into cells of mesodermal characteristics. Several studies have reported the potential pro‐or anti‐tumorigenic influence of MSCs on tumor initiation and progression. In fact, MSCs are recruited to the site of wound healing to repair damaged tissues, an event that is also associated with tumorigenesis. In other cases, resident or migrating MSCs can favor tumor angiogenesis and increase tumor aggressiveness. This interplay between MSCs and cancer cells is fundamental for cancerogenesis, progression, and metastasis. Therefore, an interesting topic is the relationship between cancer cells, CSCs, and MSCs, since contrasting reports about their respective influences have been reported. In this review, we discuss recent findings related to conflicting results on the influence of normal and CSCs in cancer development. The understanding of the role of MSCs in cancer is also important in cancer management. Stem Cells Translational Medicine 2017;6:2115–2125

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“…Moreover, aggressive melanoma cells but not poorly aggressive melanoma cells induce VM in normal human mesenchymal stromal cells in co-culture. This effect is mediated by VEGFA [ 79 ]. Treatment against aggressive melanoma cells may ignore changes in ECM, decreasing the effectiveness of the therapy.…”

Section: Vasculogenic Mimicry and Tumor Microenvironmentmentioning

confidence: 99%

Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin

et al. 2017

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Vasculogenic mimicry (VM) is a blood supply system independent of endothelial vessels in tumor cells from different origins. It reflects the plasticity of aggressive tumor cells that express vascular cell markers and line tumor vasculature. The presence of VM is associated with a high tumor grade, short survival, invasion and metastasis. Endothelial cells (ECs) express various members of the cadherin superfamily, in particular vascular endothelial (VE-) cadherin, which is the main adhesion receptor of endothelial adherent junctions. Aberrant extra-vascular expression of VE-cadherin has been observed in certain cancer types associated with VM. In this review we focus on non-endothelial VE-cadherin as a prominent factor involved in the acquisition of tubules-like structures by aggressive tumor cells and we summarize the specific signaling pathways, the association with trans-differentiation and stem-like phenotype and the therapeutic opportunities derived from the in-depth knowledge of the peculiarities of the biology of VE-cadherin and other key components of VM.

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Melanoma educates mesenchymal stromal cells towards vasculogenic mimicry

Cited by 17 publications

References 21 publications

Obesity and melanoma: could fat be fueling malignancy?

Obesity and melanoma: could fat be fueling malignancy?

Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development

Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin

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