Melanoma cell migration to type IV collagen requires activation of NF-κB

Hodgson, Louis; Henderson, Andrew J.; Dong, Chuan

doi:10.1038/sj.onc.1206059

Cited by 41 publications

(34 citation statements)

References 55 publications

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“…Type-IV collagen is a ECM protein and is highly common within the basement lamina and intima underlining the endothelium, excited chemotaxis of a number of human melanoma cell lines by engaging α2β1 integrin in vitro. Certain signal transduction incidents are driven by type-IV collagen through β1 integrins, suggesting a significant role for NF-κB in arranging chemotaxis of melanoma (9).…”

Section: Discussionmentioning

confidence: 99%

“…Increased laminin expression was also observed in melanoma cell lines and led to increased melanoma cell proliferation and metastatic potential (1-7). Similar to laminin, type-IV collagen is also an important structural component of the ECM and promotes melanoma cell adhesion, migration and invasion (6,7,(9)(10)(11). It has been proposed that type-IV collagen expression ensures the development of scaffolding required for angiogenesis in melanoma (6,7,(9)(10)(11).…”

Section: Discussionmentioning

confidence: 99%

“…Similar to laminin, type-IV collagen is also an important structural component of the ECM and promotes melanoma cell adhesion, migration and invasion (6,7,(9)(10)(11). It has been proposed that type-IV collagen expression ensures the development of scaffolding required for angiogenesis in melanoma (6,7,(9)(10)(11). Type-IV collagen is a ECM protein and is highly common within the basement lamina and intima underlining the endothelium, excited chemotaxis of a number of human melanoma cell lines by engaging α2β1 integrin in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…Increased expression of laminin and type-IV (1-7) collagen (6,7,(9)(10)(11) has also been demonstrated in melanoma cell lines with increased proliferation and metastatic potential (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

“…The proteins laminin and type-IV collagen are major structural constituents of the basement membrane, and serve as promoters of cell proliferation, differentiation, adhesion and migration via integrins and other cell surface receptors (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Increased expression of laminin and type-IV (1-7) collagen (6,7,(9)(10)(11) has also been demonstrated in melanoma cell lines with increased proliferation and metastatic potential (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

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Clinical significance of serum laminin and type-IV collagen levels in cutaneous melanoma patients

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Clinical significance of serum laminin and type-IV collagen levels in cutaneous melanoma patients

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The role of exo‐miRNA in diagnosis and treatment of cancers, focusing on effective miRNAs in colorectal cancer

Kzar Al‐Shukri,

Abdul‐Jabbar Ali,

Al‐Akkam

et al. 2024

Cell Biology International

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Small extracellular (EV) particles known as exosomes are released by a variety of cell types, including immune system cells, stem cells, and tumor cells. They are regarded as a subgroup of EVs and have a diameter that ranges from 30 to 150 nm. Proteins, lipids, nucleic acids (including RNA and DNA), and different bioactive compounds are among the wide range of biomolecules that make up the cargo of exosomes. Exosomes are crucial for intercellular communication because they let cells share information and signaling chemicals. They are involved in various physiological and pathological processes, including immune responses, tissue regeneration, cancer progression, and neurodegenerative diseases. In conclusion, it is essential to continue research into exosome‐based cancer medicines to advance understanding, improve treatment plans, create personalized tactics, ensure safety, and speed up clinical translation.

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Erythropoietin Induces an Epithelial to Mesenchymal Transition-Like Process in Mammary Epithelial Cells MCF10A

Ordoñez-Moreno

Rodriguez‐Monterrosas

Cortés‐Reynosa

et al. 2017

J. Cell. Biochem.

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Anemia is associated with chemotherapy treatment in cancer patients. Erythropoietin (EPO) has been used to treat anemia of cancer patients, because it stimulates erythropoiesis. However, treatment of breast cancer patients with EPO has been associated with poor prognosis and decrease of survival. Epithelial to mesenchymal transition (EMT) is a process by which epithelial cells are transdifferentiated to a mesenchymal state. It has been implicated in tumor progression, because epithelial cells acquire the capacity to execute the multiple steps of invasion/metastasis process. However, the role of EPO on EMT process in human mammary epithelial cells has not been studied. In the present study, we demonstrate that EPO promotes a decrease of E-cadherin expression, an increase of N-cadherin, vimentin, and Snail2 expression, activation of FAK and Src kinases and an increase of MMP-2 and MMP-9 secretions. Moreover, EPO induces an increase of NFκB DNA binding activity, an increase of binding of p50 and p65 NFκB subunits to Snail1 promoter, migration, and invasion in mammary non-tumorigenic epithelial cells MCF10A. In summary, these findings demonstrate, for the first time, that EPO induces an EMT-like process in mammary non-tumorigenic epithelial cells. J. Cell. Biochem. 118: 2983-2992, 2017. © 2017 Wiley Periodicals, Inc.

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Melanoma cell migration to type IV collagen requires activation of NF-κB

Cited by 41 publications

References 55 publications

Clinical significance of serum laminin and type-IV collagen levels in cutaneous melanoma patients

Clinical significance of serum laminin and type-IV collagen levels in cutaneous melanoma patients

The role of exo‐miRNA in diagnosis and treatment of cancers, focusing on effective miRNAs in colorectal cancer

Erythropoietin Induces an Epithelial to Mesenchymal Transition-Like Process in Mammary Epithelial Cells MCF10A

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