Melanoma : A Frequently Missed Diagnosis

Lakhtakia, Ritu; Mehta, Anurag; Nema, Shrikant

doi:10.1016/s0377-1237(09)80036-1

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…India constitutes one of the relatively low incidence regions for MM in the world. 27 At Tata Memorial Hospital, which is the premier cancer referral center of India, the incidence of MM is 0.3% among cutaneous malignancies and even rarer among non-cutaneous malignancies. This study describes the frequency of molecular alterations underlying melanomas in Indian patients at a tertiary cancer referral center.…”

Section: Discussionmentioning

confidence: 99%

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BRAF V600E Mutations and Beyond: A Molecular Perspective of Melanoma from a Tertiary Cancer Referral Center of India

Vengurlekar

Shetty

Gurav

et al. 2023

South Asian J Cancer

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Objectives Malignant melanoma demonstrates frequently occurring mutations of genes in the serine/threonine kinase pathway, namely BRAF, NRAS, and neurofibromin 1. There is rare documentation of a detailed analysis of these mutations in cases of melanoma among Indian patients. We present molecular features in cases of malignant melanoma, diagnosed at a tertiary cancer referral center in India, over a period of 8 years (2011–2018). Materials and Methods This study was performed on formalin fixed paraffin embedded tissues of 88 histologically confirmed cases of malignant melanoma. BRAF gene alterations were studied by both Sanger sequencing and real-time polymerase chain reaction techniques (n = 74). Molecular testing for BRAF and NRAS gene alterations was accomplished in 74/88 cases (80%). Molecular test results were correlated with clinicopathological features using IBM SPSS Statistical software 25.0. Results The age ranged from 13 to 79 years (median = 57), with a M:F ratio of 1.4:1. BRAF mutations were observed in 12/74 (16.21%) patients, including V600E (n = 7), A594T (n = 1), T599 = (n = 2), V600K (n = 1), and Q612P (n = 1), while NRAS mutations were observed in 6/38 (15.7%) patients. Among various subtypes, nodular melanoma was the most frequent subtype (33%) among cutaneous malignant melanomas. Among non-cutaneous melanomas, mucosal melanomas were observed in 37.5% of cases. Conclusion This constitutes one of the few reports on comprehensive analysis of molecular alterations underlying melanomas in Indian patients. A larger sample size, with more extensive molecular markers, would yield additional information on the disease manifestation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

BRAF V600E Mutations and Beyond: A Molecular Perspective of Melanoma from a Tertiary Cancer Referral Center of India

Vengurlekar

Shetty

Gurav

et al. 2023

South Asian J Cancer

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show abstract

“…India enjoys a low incidence of malignant melanoma (MM), which could be attributed to under-reporting and missed diagnosis. [ 1 ] Cancer registries in India report that the age-specific incidence rates for cutaneous MM are less than 0.5 per 1,000,000. [ 2 ] In a retrospective analysis done by Vijayakumar et al ., acral melanomas constituted 26% of all melanomas and the sole of the foot was found to be the dominant site (35 of 36 cases).…”

mentioning

confidence: 99%