Melanoma

Uren, RF; Howman-Giles, R; Je, Thompson

doi:10.1007/978-3-642-58643-9_3

Cited by 2 publications

(2 citation statements)

References 65 publications

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“…21 Extensive tabulated statistics have been published presenting the relationship between primary melanoma sites and sentinel lymph node locations. 17,20 The SMU has also published twodimensional (2D) displays 20,21 generated with geographical information systems software (see Fig.…”

Section: Introductionmentioning

confidence: 99%

Mapping Melanoma Lymphoscintigraphy Data onto a 3D Anatomically Based Model

et al. 2007

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This study describes three-dimensional (3D) visualization of two-dimensional (2D) melanoma lymphatic mapping data, to provide a framework for analysis of melanoma spread patterns and a platform for recording new lymphoscintigraphy (LS) data more accurately in 3D. Specifically, the Sydney Melanoma Unit's LS database of over 5000 patients' primary cutaneous melanoma sites and sentinel lymph nodes have been mapped from 2D images onto a 3D anatomically based model. Anatomically accurate model geometries were created using the Visible Human dataset, giving a bicubic finite element skin mesh and discrete sentinel lymph node model. The full dataset of 2D melanoma site coordinates, excluding the head and neck, has been transformed onto this 3D skin mesh via free-form deformation and projection techniques. Sentinel lymph nodes were mapped onto the generic lymph node model for each patient. Preliminary spatial analysis indicates that a patient with a primary melanoma on the torso around the waist (on the standardized 3D model this region is 180 mm above and 130 mm below the umbilicus) with lymphatic drainage to the left axilla or left groin, will have a 17.7% probability of dual drainage to both node fields, with 95% confidence limits between 14.5 and 21.0%.

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Section: Introductionmentioning

confidence: 99%

Mapping Melanoma Lymphoscintigraphy Data onto a 3D Anatomically Based Model

et al. 2007

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“…Since the first description in 1965, 99m Tc-labeled antimony trisulfide (Sb 2 S 3 , ATS) colloid has been used for bone marrow imaging [1], lymphedema assessment [2], and more recently, scintigraphic mapping of lymphatic channels and sentinel nodes [3,4] in patients with melanoma [5] and breast cancer [6,7]. In lymphoscintigraphy, a radiopharmaceutical should move at rate close to that for the physiological flow of lymph and should be sufficiently well retained by the intervening nodes.…”

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confidence: 99%

New technology of technetium-99 labeled antimony trisulfide colloid intended for sentinel lymph node imaging

Shah

2006

Pharm Chem J

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99m Tc-Labeled antimony trisulfide (ATS) colloid is a radiopharmaceutical that can be useful in evaluation of the patients with breast cancer. The existing 99m Tc-ATS preparation method involves a lengthy procedure of boiling on a water bath; the recommended quality control procedure is also rather laborious and time consuming. Using a microwave oven, the heating time necessary to provide a maximum labeling efficiency can be reduced to 15 sec. A new minipaper chromatography (MPC) system involving two developing solvents has been developed to analyze the radiochemical purity (RCP) of the labeled preparation. The conventional thin layer chromatography (TLC) system involving the use of an Al 2 O 3 coated plate requires an average time of 38.4 ± 0.21 min (n = 30) for complete drying and development, whereas the new MPC system has an average development time of 4.1 ± 0.32 min (n = 20). In the RCP evaluation, the MPC and TLC methods give closely correlated results (r = 0.94). The combined use of the proposed microwave heating technique and the rapid MPC quality control system facilitate the emergency use of 99m Tc-ATS colloid diagnostics.

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Melanoma

Cited by 2 publications

References 65 publications

Mapping Melanoma Lymphoscintigraphy Data onto a 3D Anatomically Based Model

Mapping Melanoma Lymphoscintigraphy Data onto a 3D Anatomically Based Model

New technology of technetium-99 labeled antimony trisulfide colloid intended for sentinel lymph node imaging

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