Melanocytoma and meningeal melanocytosis, similar but different lesions

Padilla-Vázquez, Felipe; Garma, Víctor Hugo Escobar-de la; Ayala-Arcipreste, Arturo; Mendizábal-Guerra, Rafael; Cuesta-Mejía, Teresa

doi:10.1016/j.circen.2017.05.015

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…30 The HM19 cell line may provide a missing research tool also for studying the biology of this disease manifestation. 17,19,30,31 The intracardiac injection of cells results in hematogenous spread throughout the animals, in our case with a very good take rate (90%). However, this approach also has its clear limitations as 500,000 tumor cells were injected over a very short period into the systemic circulation, a situation that can lead to intravascular cancer cell aggregates, and misguided injections may result in perfusion to the pulmonary circulation or thorax.…”

Section: Discussionsupporting

confidence: 49%

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Novel human melanoma brain metastasis models in athymic nude fox1^nu mice: Site‐specific metastasis patterns reflecting their clinical origin

et al. 2021

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Background Malignant melanomas frequently metastasize to the brain, but metastases in the cerebellum are underrepresented compared with metastases in the cerebrum. Methods We established animal models by injecting intracardially in athymic nude fox1nu mice two human melanoma cell lines, originating from a cerebral metastasis (HM19) and a cerebellar metastasis (HM86). Results Using magnetic resonance imaging (MRI), metastases were first detected after a mean of 34.5 days. Mean survival time was 59.6 days for the mice in the HM86 group and significantly shorter (43.7 days) for HM19‐injected animals (p < 0.001). In the HM86 group, the first detectable metastasis was located in the cerebellum in 15/55 (29%) mice compared with none in the HM19 group (p < 0.001). At sacrifice, cerebellar metastases were found in 34/55 (63%) HM86‐injected mice compared with 1/53 (2%) in the HM19‐injected (p < 0.001) mice. At that time, all mice in both groups had detectable metastases in the cerebrum. Comparing macroscopic and histologic appearances of the brain metastases with their clinical counterparts, the cell line‐based tumors had kept their original morphologic characteristics. Conclusions The present work demonstrates that human brain‐metastatic melanoma cells injected intracardially in mice had retained inherent characteristics also in reproducing interaction with subtle microenvironmental brain tissue compartment‐specific features. The models offer new possibilities for investigating tumor‐ and host‐associated factors involved in determining tissue specificity of brain metastasis.

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Section: Discussionsupporting

confidence: 49%

“…However, it is known that clinical leptomeningeal MM metastases are associated with rapid disease progression with a mean survival of only 8–10 weeks after being diagnosed 30 . The HM19 cell line may provide a missing research tool also for studying the biology of this disease manifestation 17,19,30,31 …”

Section: Discussionmentioning

confidence: 99%

Novel human melanoma brain metastasis models in athymic nude fox1^nu mice: Site‐specific metastasis patterns reflecting their clinical origin

et al. 2021

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“…The World Health Organization (WHO) classification divides the melanocytic lesions of the central nervous system into three types: diffuse melanosis, meningeal melanocytoma (benign course), and melanoma [ 210 ]. Considering the latter, two forms of PIMM should be highlighted: solid tumors and diffuse meningeal melanomatosis [ 211 ].…”

Section: Unusual or Unknown Primary Site Melanomasmentioning

confidence: 99%

Uncommon Subtypes of Malignant Melanomas: A Review Based on Clinical and Molecular Perspectives

Chacón

Pflüger

Ángel

et al. 2020

Cancers

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Malignant melanoma represents the most aggressive type of skin cancer. Modern therapies, including targeted agents and immune checkpoint inhibitors, have changed the dismal prognosis that characterized this disease. However, most evidence was obtained by studying patients with frequent subtypes of cutaneous melanoma (CM). Consequently, there is an emerging need to understand the molecular basis and treatment approaches for unusual melanoma subtypes. Even a standardized definition of infrequent or rare melanoma is not clearly established. For that reason, we reviewed this challenging topic considering clinical and molecular perspectives, including uncommon CMs—not associated with classical V600E/K BRAF mutations—malignant mucosal and uveal melanomas, and some unusual independent entities, such as amelanotic, desmoplastic, or spitzoid melanomas. Finally, we collected information regarding melanomas from non-traditional primary sites, which emerge from locations as unique as meninges, dermis, lymph nodes, the esophagus, and breasts. The aim of this review is to summarize and highlight the main scientific evidence regarding rare melanomas, with a particular focus on treatment perspectives.

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Melanocytoma and meningeal melanocytosis, similar but different lesions

Cited by 2 publications

References 17 publications

Novel human melanoma brain metastasis models in athymic nude fox1^nu mice: Site‐specific metastasis patterns reflecting their clinical origin

Novel human melanoma brain metastasis models in athymic nude fox1^nu mice: Site‐specific metastasis patterns reflecting their clinical origin

Uncommon Subtypes of Malignant Melanomas: A Review Based on Clinical and Molecular Perspectives

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Melanocytoma and meningeal melanocytosis, similar but different lesions

Cited by 2 publications

References 17 publications

Novel human melanoma brain metastasis models in athymic nude fox1nu mice: Site‐specific metastasis patterns reflecting their clinical origin

Novel human melanoma brain metastasis models in athymic nude fox1nu mice: Site‐specific metastasis patterns reflecting their clinical origin

Uncommon Subtypes of Malignant Melanomas: A Review Based on Clinical and Molecular Perspectives

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Novel human melanoma brain metastasis models in athymic nude fox1^nu mice: Site‐specific metastasis patterns reflecting their clinical origin

Novel human melanoma brain metastasis models in athymic nude fox1^nu mice: Site‐specific metastasis patterns reflecting their clinical origin