Melanocytic Tumors, Skin, Mouse

Kanno, Jun

doi:10.1007/978-3-642-83749-4_10

Cited by 9 publications

(4 citation statements)

References 11 publications

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“…Melanoblasts, however, may also reside in the dermis where they can proliferate and cause pigmented neoplasms ( 64 Kanno, 1989).…”

Section: Nomenclaturementioning

confidence: 99%

“…Melanocytes in the skin of mice only briefly reside in the epidermis of the trunk ( 88 Noonan et al, 2000). Melanoblasts, however, may also reside in the dermis where they can proliferate and cause pigmented neoplasms ( 64 Kanno, 1989).…”

Section: Nomenclaturementioning

confidence: 99%

“…Predilection sites for amelanotic melanomas in rats are ear pinna, eyelid, scrotum and perianal area. ( 7 Bader et al, 1993; 14 Bogovski, 1994; 28 Deerberg et al, 1986; 33 Evans et al, 1997; 64 Kanno, 1989; 67 Kort et al, 1984; 99 Peckham and Heider, 1999; 103 Ramon y Cajal et al, 1991; 132 Weiss and Frese, 1974; 136 Yoshitomi and Boorman, 1993; 138 Yoshitomi et al, 1995; 141 Zackheim et al, 1990; 143 Zurcher and Roholl, 1989; 144 Zwicker et al, 1992; 18 Burek, 1978; 131 Ward et al, 1979; 112 Sher, 1982; 115 Sommer, 1997; 42 Goerttler et al, 1984; 11 Berkelhammer and Oxenhandler, 1987)…”

Section: Nomenclaturementioning

confidence: 99%

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Proliferative and Non-Proliferative Lesions of the Rat and Mouse Integument

Mecklenburg¹,

Kusewitt

Kolly

et al. 2013

J Toxicol Pathol

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) project is a joint initiative of the societies of toxicological pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP). Its aim is to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory rodents. A widely accepted international harmonization of nomenclature in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and will provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists. The purpose of this publication is to provide a standardized nomenclature for classifying microscopical lesions observed in the integument of laboratory rats and mice. Example colour images are provided for most lesions. The standardized nomenclature presented in this document and additional colour images are also available electronically at http://www.goreni.org. The nomenclature presented herein is based on histopathology databases from government, academia, and industrial laboratories throughout the world, and covers lesions that develop spontaneously as well as those induced by exposure to various test materials. (DOI: 10.1293/tox.26.27S; J Toxicol Pathol 2013; 26: 27S–57S)

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“…Melanoblasts, however, may also reside in the dermis where they can proliferate and cause pigmented neoplasms ( 64 Kanno, 1989).…”

Section: Nomenclaturementioning

confidence: 99%

Section: Nomenclaturementioning

confidence: 99%

Section: Nomenclaturementioning

confidence: 99%

See 1 more Smart Citation

Proliferative and Non-Proliferative Lesions of the Rat and Mouse Integument

Mecklenburg¹,

Kusewitt

Kolly

et al. 2013

J Toxicol Pathol

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“…Melanocytes of the pigmented murine skin are normally present in the epidermis, dermis, hair bulbs, and perifollicular melanoCy1ic networks (16). In hooded mice, chemically induced melanoma is considered to originate from perifollicular melanocytes (16).…”

Section: Introductionmentioning

confidence: 99%

Pathology and Incidence of Amelanotic Melanomas of the Skin in F-344/N Rats

Yoshitomi¹,

Elwell

Boorman

1995

Toxicol Pathol

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Animal Models of Bone Metastasis

Rosol

Tannehill-Gregg²,

Corn³

et al. 2004

Cancer Treatment and Research

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Bone is one of the most common sites of cancer metastasis in humans and is a significant source of morbidity and mortality. Bone metastases are considered incurable and result in pain, pathologic fracture, and decreased quality of life. Animal models of skeletal metastases are essential to improve the understanding of the molecular pathways of cancer metastasis and growth in bone and to develop new therapies to inhibit and prevent bone metastases. The ideal animal model should be clinically relevant, reproducible, and representative of human disease. Currently, an ideal model does not exist; however, understanding the strengths and weaknesses of the available models will lead to proper study design and successful cancer research. This review provides an overview of the current in vivo animal models used in the study of skeletal metastases or local tumor invasion into bone and focuses on mammary and prostate cancer, lymphoma, multiple myeloma, head and neck squamous cell carcinoma, and miscellaneous tumors that metastasize to bone. Keywordscancer; mammary; prostate; squamous cell carcinoma; dog; cat; parathyroid hormone; related protein; osteoblastic Cancer is the second leading cause of death in the United States, behind only heart disease. Death in patients with cancer is often due to metastasis, and one of the most common sites is bone. 109 Skeletal metastases are frequent in patients with breast, prostate, and lung cancer but also occur in other tumors such as myeloma, thyroid and renal cancer, lymphoma, Ewing sarcoma, and infrequently in other cancers. 110,146 Bone metastases can result in osteolytic (bone-resorbing) or osteoblastic (bone-forming) metastases that can cause pain, pathologic fractures, and mortality. 108,163 The general pathogenesis of bone metastasis involves proliferation of the primary neoplasm, local tissue invasion, intravasation into blood vessels, extravasation into the bone marrow, a Reprints and permission: sagepub.com/journalsPermissions.nav Corresponding Author: T. J. Rosol, Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Rd., Columbus, OH 43210, USA. rosol.1@osu.edu. Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. HHS Public AccessAuthor manuscript Vet Pathol. Author manuscript; available in PMC 2015 September 01. Author Manuscript Author ManuscriptAuthor ManuscriptAuthor Manuscript variable time of tumor cell dormancy, proliferation in bone, and modification of the bone microenvironment. 30 The current hypothesis for preferential localization of cancer cells in bone is the "seed and soil" hypothesis of Paget, 95 which states that neoplastic cells (seeds) grow or proliferate only in a suitable soil, such as the bone marrow. This hypothesis has remained intact for over 100 years; however, now there is a deeper appreciation for the important role that the bone marrow microenvironment plays in metastasis. The metastatic tumor...

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Melanocytic Tumors, Skin, Mouse

Cited by 9 publications

References 11 publications

Proliferative and Non-Proliferative Lesions of the Rat and Mouse Integument

Proliferative and Non-Proliferative Lesions of the Rat and Mouse Integument

Pathology and Incidence of Amelanotic Melanomas of the Skin in F-344/N Rats

Animal Models of Bone Metastasis

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