Melanocytic nevus density in Asian, Indo-Pakistani, and white children: The Vancouver Mole Study

Gallagher, Richard P.; Rivers, Jason K.; Yang, Charlie; McLean, David I.; Coldman, Andrew J.; Silver, Hulbert K. B.

doi:10.1016/0190-9622(91)70231-p

Cited by 35 publications

(20 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In agreement with data from previous studies of naevus distribution in children (26,32) we found differences in naevus pattern of the trunk between the two sexes, with boys having more naevi than girls in this region. In the Vancouver Mole studies (26,33) this difference was noted as early as in the 6 -12-year-old age group, but became even more pronounced in the 13 -18-year-old group (26). We found no significant gender-related difference in the number of naevi on the legs, which is in contrast to studies performed in adult Swedes (2,15).…”

Section: Discussioncontrasting

confidence: 81%

Frequency and Distribution Pattern of Melanocytic Naevi in Swedish 8-9-year-old Children

Synnerstad¹,

Nilsson²,

Fredrikson³

et al. 2004

Acta Dermato-Venereologica

View full text Add to dashboard Cite

The naevus profile was examined in a Swedish cohort of 8-9-year-old children; 524/545 individuals (96%) were examined (279 boys and 245 girls). There was a wide variation in the total number of naevi (0-79) and boys had more naevi than girls (median 9 and 7, respectively, p<0.01). No dysplastic naevi were found. Overall, 15/ 524 (3%) had at least one lesion clinically diagnosed as a congenital melanocytic naevus. Boys had more naevi on the face (median 1) and trunk (median 5) than girls (median 0 and 3, respectively, p<0.001). There was no difference in the number of naevi on the legs between the two sexes. The highest counts per unit surface area for both sexes were found on the back, chest and the lateral aspect of the arms, areas intermittently sun-exposed. Children with fair skin and light eye colours had significantly more naevi than those with darker colours but children with red hair had very few naevi. Children with one or more naevi on the buttocks (25%), dorsal surfaces of the feet (11%) or on the scalp (7%) had twice as many naevi in total compared with those without naevi in these regions. Children with naevi in all three regions (0.8%) had four times as many naevi in total. A relationship between total counts and counts on the back or lateral aspect of the arms was found (r2 = 0.59). Either of these two areas might be suitable for predicting total naevus counts.

show abstract

Section: Discussioncontrasting

confidence: 81%

Frequency and Distribution Pattern of Melanocytic Naevi in Swedish 8-9-year-old Children

Synnerstad¹,

Nilsson²,

Fredrikson³

et al. 2004

Acta Dermato-Venereologica

View full text Add to dashboard Cite

show abstract

“…Moreover the susceptibility to develop MN depends on skin complexion and populations with pigmentary traits that protect the skin more effectively against solar radiation develop fewer nevi. 14,35,36 In our study, there was a clear association of ethnicity of parents with MN counts in children in the cross-sectional 19 and longitudinal analysis. Most non- …”

Section: Discussionmentioning

confidence: 80%

Risk factors of incident melanocytic nevi: A longitudinal study in a cohort of 1,232 young German children

Bauer

Büttner

Wiecker

et al. 2005

Intl Journal of Cancer

View full text Add to dashboard Cite

The number of melanocytic nevi is the most important independent risk factor for cutaneous melanoma. Aim of our study was to add information to the controversial discussion on the role of chronic-moderate and intermittent-high sun exposure and sunburns for the development of melanocytic nevi by the use of a large longitudinal study. A longitudinal study with a 3-year follow-up was conducted in 1,232 young children 2-7 years of age attending 78 public nursery schools in Bochum and Stuttgart, Germany. Total body nevus counts, assessment of pigmentary features and nevus counts on arms of parents were carried out. Parents underwent a standardized interview concerning sun exposure, sunburns and sun-protective behavior. Applying multiple linear regression analysis higher numbers of incident nevi were associated with host factors like light skin complexion (skin Type II vs. IV, p ‫؍‬ 0.022) and freckling of the face (p < 0.001), with parental factors like nevus counts on mothers' (p < 0.001) and fathers' (p ‫؍‬ 0.004) arms and at least one parent being of German descent (p ‫؍‬ 0.006), and with environmental factors like intermittent-high sun exposure during holidays (p < 0.001) and chronic-moderate ultraviolet radiation at home (p ‫؍‬ 0.007). Sunburns were a significant risk factor for nevus development (p ‫؍‬ 0.005). Total cumulative sun exposure seems to be the crucial environmental risk factor for the development of nevi, whether the child is exposed to chronicmoderate or intermittent-high ultraviolet light doses. Public health education should focus primarily on avoiding sun exposure especially in children with fair skin and parents with high nevus counts. The total number of melanocytic nevi (MN) on the body is known to be the strongest intrinsic risk factor for the development of cutaneous melanoma (CM). 1-5 Moreover, MN were considered to be precursor lesions of a substantial proportion of CM. 6,7 Case control studies on risk factors for CM in adults are influenced by recall bias. 8 Childhood is a period of particular susceptibility to the carcinogenic effects of solar radiation. 9 Thus, studies on MN in children might give new insights into the pathogenesis of CM.To date, numerous cross-sectional studies have been published identifying risk factors for MN development in children. 10 -19 Studies yielded partly contradicting results to important points like the amount and intensity of sun exposure needed for MN development and the role of sunburns. Few longitudinal studies exist that investigated risk factors for incident MN. 20 -24 Such studies might give a better control of the influence of environmental factors and confounders. Our present study longitudinally investigated risk factors for the development of MN in a cohort of 1,232 German kindergarten children, 2-7 years of age, followed-up over a 3-year period. Material and methods ParticipantsOur analysis utilized data of children who participated in a randomized controlled trial set up to investigate whether educational intervention and the provision of ...

show abstract

“…One United States study found an association between iris nevi and iris melanoma but not an association between choroidal nevi and choroidal melanoma. 35 Although cutaneous nevi are known to reflect a combination of the subjects' pigmentary traits, sun sensitivity and sun exposure, 36,37 risk factors for choroidal nevi are unknown. Eye color, skin color and sun-induced skin damage had no association with choroidal nevi in an Australian study.…”

Section: Discussionmentioning

confidence: 99%

Eye color and cutaneous nevi predict risk of ocular melanoma in Australia

Vajdic¹,

Kricker

Giblin

et al. 2001

Int. J. Cancer

View full text Add to dashboard Cite

Ethnicity, cutaneous nevi and eye color are generally accepted risk factors for melanoma of the eye, although casecontrol studies have produced conflicting results. We sought to determine the constitutional risk factors for melanomas of the choroid, ciliary body, iris and conjunctiva in Australia. A population-based case-control study was conducted, with case ascertainment from a prospective national incidence survey and randomly selected community controls. Two hundred and ninety cases aged 18 -79 years and diagnosed between 1st January 1996 and 31st July 1998 were enrolled with 916 controls frequency matched by age, sex and State or Territory of residence. Risk of choroidal and ciliary body melanoma (n ‫؍‬ 246) was increased in people with grey (OR 2.9, 95% CI 1.5-5.5), hazel (OR 2.2, 95% CI 1.4 -3.7) and blue eyes (OR 1.7, 95% CI 1.0 -2.7) compared with brown eyes. Risk was also increased in those with 4 or more nevi on their back, those unable to tan, and those who squinted when outdoors as a child. Risk was reduced in people born other than in Australia and New Zealand (OR 0.7, 95% CI 0.5-1.0). Non-brown eye color was a risk factor for iris melanoma (n ‫؍‬ 25). No risk factors were identified for conjunctival melanoma (n ‫؍‬ 19). Eye color is the strongest constitutional predictor of choroidal and ciliary body melanoma, and may indicate a protective effect of melanin density at these sites. An independent association with cutaneous nevi suggests a role for other genetic factors.

show abstract

Melanocytic nevus density in Asian, Indo-Pakistani, and white children: The Vancouver Mole Study

Cited by 35 publications

References 12 publications

Frequency and Distribution Pattern of Melanocytic Naevi in Swedish 8-9-year-old Children

Frequency and Distribution Pattern of Melanocytic Naevi in Swedish 8-9-year-old Children

Risk factors of incident melanocytic nevi: A longitudinal study in a cohort of 1,232 young German children

Eye color and cutaneous nevi predict risk of ocular melanoma in Australia

Contact Info

Product

Resources

About