Melanocytic and nevocytic malignant melanomas.Cellular and subcellular differentiation

Mishima, Yutaka

doi:10.1002/1097-0142(1967)20:5<632::aid-cncr2820200510>3.0.co;2-7

Cited by 141 publications

(30 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is also supported by ultrastructural evidence (32). Remnants of normal nevi, and melanocytic dysplasia associated with sun damage, have been found in excision biopsies of SSM (33).…”

Section: -5 >5mentioning

confidence: 56%

Melanocytic Nevi and Risk of Cutaneous Malignant Melanoma in Southern Spain

Ródenas

Delgado-Rodrı́guez

Fariñas‐Álvarez

et al. 1997

American Journal of Epidemiology

View full text Add to dashboard Cite

The main objective of this study was to assess whether cutaneous malignant melanoma (CMM) shows a stronger relation with the melanocytic nevi count at the site where CMM was diagnosed than with the melanocytic nevi count at other sites, stratifying by histologic CMM type, in a southern Mediterranean population. Cases and controls were selected from a population in southern Spain in 1988-1993. The study population included 116 incident cases with non-familial CMM (International Classification of Diseases 9th Revision (ICD-9) code 172), and 116 controls matched 1:1 for sex and age (+/- 4 years). Data were collected by personal interview, and melanocytic nevi were counted over the entire body surface by clinical skin examination performed by a dermatologist. Crude and multiple risk factor-adjusted odds ratios and 95% confidence intervals were computed by conditional logistic regression analysis. After adjustment by skin type, unexposed skin color, and sun exposure, CMM was found to occur significantly more frequently in individuals with a high number of melanocytic nevi at the same site where CMM originated (odds ratio (OR) for >8 nevi = 12.0, 95% confidence interval (CI) 1.3-108.2). The ability to predict the number of melanocytic nevi on different anatomic sites on CMM, but excluding the CMM cases on each corresponding site, was also examined. A significant trend with the number of nevi on the anterior surface of thighs was found (OR for >4 nevi = 4.5, 95% CI 1.4-14.9). Melanocytic nevi count on the melanoma site was the variable most closely related to superficial spreading melanoma subtype (SSM) (OR for >8 nevi = 82.19, 95% CI 2.72-2,454). On the other hand, the number of melanocytic nevi on the melanoma site was unrelated to risk of CMM subtypes other than SSM. These results support the hypothesis that nevi are an important risk factor for melanoma, especially SSM, in populations with a darker ethnic background.

show abstract

“…This is also supported by ultrastructural evidence (32). Remnants of normal nevi, and melanocytic dysplasia associated with sun damage, have been found in excision biopsies of SSM (33).…”

Section: -5 >5mentioning

confidence: 56%

Melanocytic Nevi and Risk of Cutaneous Malignant Melanoma in Southern Spain

Ródenas

Delgado-Rodrı́guez

Fariñas‐Álvarez

et al. 1997

American Journal of Epidemiology

View full text Add to dashboard Cite

show abstract

“…The patients with melanoma were similar in distributions of sex, age, and histological type to all patients with melanoma in Scotland during 1979-84" (Scottish Melanoma Group, unpublished findings) except that in our patients the proportions aged 70 or more and with lentigo maligna melanoma were smaller (I 2% (21) compared with 27% (444) and 9% (p16) compared with 15% (247)) respectively. The controls had a wide range of conditions at admission, the most common being hypertension (55 patients), psoriasis (31), and fractures and dislocations (20). Altogether 214 (82%) of the 262 examinations in Glasgow were conducted by one dermatologist (JE) and 103 (90%) of the 115 examinations in Edinburgh by another (CJO'D), often with simultaneous examination of the subjects by the second dermatologist at the centre to improve validity.…”

Section: Resultsmentioning

confidence: 99%

Benign melanocytic naevi as a risk factor for malignant melanoma.

Swerdlow¹,

English²,

Mackie³

et al. 1986

BMJ

318

View full text Add to dashboard Cite

1555ouabain binding capacity of cells from patients with essential hypertension can increase during incubation in the absence of the inhibitor. We do not suggest that the serum inhibitor is solely responsible for the disorder of leucocyte transport of cations in essential hypertension. Our study does not exclude a deficiency of other, ouabain resistant, cation transport pumps in the leucocyte.Our findings show, however, that the leucocyte is a useful model for studying in vitro the defects of transmembrane cation transport in essential hypertension.We are grateful for the advice of the late Dr R P S Edmondson of the department of renal medicine, Singapore General Hospital. We thank Ms S B Yeo, Ms C S Hay, and Abstract Examination of180 patients with cutaneous malignant melanoma and 197 control patients in a case-control study showed that the risk of melanoma is strongly related to numbers of benign melanocytic naevi (moles). Some unusual features of naevi-a diameter exceeding 7 mm, colour variation, and irregular lateral outline-also showed a strong association with the risk of melanoma, but the relation of numbers of naevi to risk was present even in the group of.patients whose naevi had none of these unusual features. Biopsy of clinically atypical naevi from several of the patients at highest risk generally did not show University of Glasgow A J SWERDLOW, PHD, AMFcM, senior lecturer, department of community medicine J ENGLISH, As, MRcP, registrar, department of dermatology R M MAcKIE, FRSE, FRCPATH, professor, department of dermatology J CLARK, Bsc, research assistant, department of community medicine

show abstract

“…More than 40 years ago, Mishima proposed two age-related pathways for cutaneous malignant melanomas CMMs that were linked to sun exposure (e.g., melanocytic and nevocytic) 20. Chronic sun exposure was a direct risk factor for melanocytic but not for nevocytic melanomas.…”

Section: Discussionmentioning

confidence: 99%

Divergent cancer pathways for early‐onset and late‐onset cutaneous malignant melanoma

Anderson

Pfeiffer

Tucker

et al. 2009

Cancer

View full text Add to dashboard Cite

BACKGROUND: Emerging data suggest that cutaneous malignant melanomas (CMM) may arise through divergent cancer pathways that are linked to intermittent versus accumulated sun exposure. However, numerous questions remain regarding the timing and/or age of exposure. METHODS: The authors systematically examined the effect of aging on CMM incidence in data from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute. Standard descriptive epidemiology was supplemented with mathematical models. The impact of advancing age on CMM incidence was assessed by sex, histopathologic classification (superficial spreading melanoma [SSM] or lentigo maligna melanoma [LMM]), and anatomic site (face, head, and neck [FHN] or lower extremity [LE]). RESULTS: Sex, histopathology, and anatomic site were age‐specific effect modifiers for CMM that indicated divergent (bimodal) early‐onset and late‐onset cancer pathways. Early‐onset melanomas were associated predominantly with women, SSM, and LE. Late‐onset melanomas were correlated with men, LMM, and FHN. Early‐ and late‐onset melanoma populations were confirmed with age‐period‐cohort models that were adjusted for period and cohort effects. Two‐component mixture models also fit the data better than a single cancer population. CONCLUSIONS: The current results were consistent with a divergent and age‐dependent solar hypothesis for CMM. Early‐onset melanomas may represent gene‐sun exposure interactions that occur early (and/or intermittently) in life among susceptible individuals. Late‐onset melanomas may reflect accumulated, lifelong sun exposure in comparatively less susceptible individuals. Future analytical studies should be powered adequately to account for this age‐dependent effect modification both for acknowledged melanoma risk factors (sex, histopathology, and anatomic site) and for suspected melanoma risk factors, such as constituent genetic variants. Cancer 2009. Published 2009 by the American Cancer Society.

show abstract

Melanocytic and nevocytic malignant melanomas.Cellular and subcellular differentiation

Cited by 141 publications

References 5 publications

Melanocytic Nevi and Risk of Cutaneous Malignant Melanoma in Southern Spain

Melanocytic Nevi and Risk of Cutaneous Malignant Melanoma in Southern Spain

Benign melanocytic naevi as a risk factor for malignant melanoma.

Divergent cancer pathways for early‐onset and late‐onset cutaneous malignant melanoma

Contact Info

Product

Resources

About