Melanocyte-specific CD8+ T cells are associated with epidermal depigmentation in a novel mouse model of vitiligo

You, Sooseong; Cho, Y. H.; Byun, Jin‐Seok; Shin, Eui‐Cheol

doi:10.1111/cei.12146

Cited by 27 publications

(28 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of CD8-positive lymphocytes tagging the dermoepidermal junction as well as ringing melanocytes is in line with recent work in murine models implicating CD8-positive cells as the effectors of melanocyte death [7]. Other reports in the literature describe the inflammatory border of IVRB as presenting with band-like infiltration of lymphocytes in the upper dermis, including CD4-positive and CD8-positive cells (see table 1 for selected examples) [2,8,11,12]. Le Poole et al [6] suggest that HLA-DR expression along stretches of basal and suprabasal keratinocytes may contribute to local T cell reactivity.…”

Section: Discussionsupporting

confidence: 79%

Repigmentation of Extensive Inflammatory Vitiligo with Raised Borders Using Early and Aggressive Treatment

Gunasekera

Murphy²,

Sheth³

2014

Dermatology

View full text Add to dashboard Cite

Inflammatory vitiligo with raised borders (IVRB) is a rare subtype of vitiligo described as having a rim of raised erythema at the periphery of the depigmented patches. The etiology is poorly understood, and there are few reports of successful treatment of the condition in the literature. We report a 38-year-old South Asian male who presented with diffuse depigmented macules and patches surrounded by blue-gray rims involving a large body surface area. Light microscopy revealed inflammatory vitiligo. He was treated with 2 courses of oral prednisone and whole-body narrow-band ultraviolet B (NB-UVB) therapy, which resulted in cessation of disease spread as well as substantial repigmentation. Our observation suggests that early and aggressive treatment can lead to significant and rapid improvement in patients with IVRB.

show abstract

Section: Discussionsupporting

confidence: 79%

Repigmentation of Extensive Inflammatory Vitiligo with Raised Borders Using Early and Aggressive Treatment

Gunasekera

Murphy²,

Sheth³

2014

Dermatology

View full text Add to dashboard Cite

show abstract

“…Vitiligo was induced by TRP2-180 immunization in mice as described previously (7). Briefly, C57BL/6 mice were subcutaneously immunized in the footpad with TRP2-180 (5 nmole), LPS (5µg) and CpG ODN (5µg) twice at 1-week intervals.…”

Section: Methodsmentioning

confidence: 99%

“…We used a mouse model of vitiligo which is induced by immunization of K b -binding tyrosinase-related protein 2 (TRP2)-180 peptide. Previously, we established a novel mouse model of vitiligo by immunization with TRP2-180 peptide in combination with lipopolysaccharides (LPS) and CpG oligodeoxynucleotides (CpG ODN) (7). This mouse model of vitiligo was characterized by progressive depigmentation of the skin due to selective loss of melanocytes.…”

Section: Introductionmentioning

confidence: 99%

Priming of Autoreactive CD8⁺T Cells Is Inhibited by Immunogenic Peptides Which Are Competitive for Major Histocompatibility Complex Class I Binding

et al. 2013

View full text Add to dashboard Cite

In the present study, we investigated if priming of autoreactive CD8+ T cells would be inhibited by competitive peptides for major histocompatibility complex (MHC) class I binding. We used a mouse model of vitiligo which is induced by immunization of Kb-binding tyrosinase-related protein 2 (TRP2)-180 peptide. Competitive peptides for Kb binding inhibited IFN-γ production and proliferation of TRP2-180-specific CD8+ T cells upon ex vivo peptide restimulation, while other MHC class I-binding peptides did not. In mice, the capability of inhibition was influenced by T-cell immunogenicity of the competitive peptides. The competitive peptide with a high T-cell immunogenicity efficiently inhibited priming of TRP2-180-specific CD8+ T cells in vivo, whereas the competitive peptide with a low T-cell immunogenicity did not. Taken together, the inhibition of priming of autoreactive CD8+ T cells depends on not only competition of peptides for MHC class I binding but also competitive peptide-specific CD8+ T cells, suggesting that clonal expansion of autoreactive T cells would be affected by expansion of competitive peptide-specific T cells. This result provides new insights into the development of competitive peptides-based therapy for the treatment of autoimmune diseases.

show abstract

“…Autoantibodies against tyrosine hydroxylase and various pigment cell-surface antigens that are specific to melanocytes have been identified in the sera of vitiligo patients [42,43]. Additionally, studies have supported a melanocyte-specific immune reaction driven by cytotoxic CD8+ T cells[44,45]. Lastly, Th1, Th2, and more recently Th17 type cytokines have been significantly quantified in the sera and skin of patients with vitiligo[46,47].…”

Section: Vitiligomentioning

confidence: 99%

“…CD8+ T cells kill self-cells upon antigen recognition and form a critical component of adaptive immunity. These cells have been implicated in the direct killing of melanocytes in vitiligo models[60,73], and thus their recruitment by IL-17 may play an important role in disease pathogenesis[44,74–76]. …”

Section: Putative Roles For Il-17 In Vitiligo Pathogenesismentioning

confidence: 99%

The role of IL-17 in vitiligo: A review

Singh

Lee

Vujkovic-Cvijin

et al. 2016

Autoimmunity Reviews

111

101

View full text Add to dashboard Cite

IL-17 is involved in the pathogenesis of several autoimmune diseases, however its role in vitiligo has not been well defined. Emerging human and mouse studies have demonstrated that systemic, tissue, and cellular levels of IL-17 are elevated in vitiligo. Many studies have also shown significant positive correlations between these levels and disease activity, extent, and severity. Treatments that improve vitiligo, such as ultraviolet B phototherapy, also modulate IL-17 levels. This review synthesizes our current understanding of how IL-17 may influence the pathogenesis of autoimmune vitiligo at the molecular level. This has implications for defining new vitiligo biomarkers and treatments.

show abstract

Melanocyte-specific CD8+ T cells are associated with epidermal depigmentation in a novel mouse model of vitiligo

Abstract: SummaryIn the present study, we established a novel murine model of vitiligo by sequential prime/boost immunizations into the hind footpad and tail dermis with tyrosinase-related protein 2 (

Cited by 27 publications

References 16 publications

Repigmentation of Extensive Inflammatory Vitiligo with Raised Borders Using Early and Aggressive Treatment

Repigmentation of Extensive Inflammatory Vitiligo with Raised Borders Using Early and Aggressive Treatment

Priming of Autoreactive CD8⁺T Cells Is Inhibited by Immunogenic Peptides Which Are Competitive for Major Histocompatibility Complex Class I Binding

The role of IL-17 in vitiligo: A review

Contact Info

Product

Resources

About

Melanocyte-specific CD8+ T cells are associated with epidermal depigmentation in a novel mouse model of vitiligo

Abstract: SummaryIn the present study, we established a novel murine model of vitiligo by sequential prime/boost immunizations into the hind footpad and tail dermis with tyrosinase-related protein 2 (

Cited by 27 publications

References 16 publications

Repigmentation of Extensive Inflammatory Vitiligo with Raised Borders Using Early and Aggressive Treatment

Repigmentation of Extensive Inflammatory Vitiligo with Raised Borders Using Early and Aggressive Treatment

Priming of Autoreactive CD8+T Cells Is Inhibited by Immunogenic Peptides Which Are Competitive for Major Histocompatibility Complex Class I Binding

The role of IL-17 in vitiligo: A review

Contact Info

Product

Resources

About

Priming of Autoreactive CD8⁺T Cells Is Inhibited by Immunogenic Peptides Which Are Competitive for Major Histocompatibility Complex Class I Binding