Melanocyte precursors express elastin binding protein and elastin-derived peptide (VGVAPG) stimulates their melanogenesis and dendrite formation

Chang, Chia-Wen; Kawa, Yoko; Tsai, Rong‐Kung; Shieh, Jia-Hung; Lee, Jeng-Woei; Watabe, Hidenori; Kawakami, Tamihiro; Soma, Yoshinao; Tajima, S.; Mizoguchi, Masahiro

doi:10.1016/j.jdermsci.2008.03.010

Cited by 20 publications

(18 citation statements)

References 36 publications

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“…These data suggest that these spindle cells were of glial origin. Although this idea is consistent with the extracellular matrix around aplasia cutis lacking elastic fibers, an in vitro study reported that elastin might play a role in the differentiation of melanocyte precursors 6 . When both pathological specimens were stained with elastica van Gieson’s stain, almost all of the mucinous interstitial tissue around the melanocytes was noted to lack elastic fibers, and melanocytes were located with or without association with adjacent fine elastic fibers in both cases (Fig.…”

mentioning

confidence: 53%

Two cases of congenital aplasia cutis with dermal melanocytosis

Uehara¹,

Hatano²,

Kato³

et al. 2011

The Journal of Dermatology

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mentioning

confidence: 53%

Two cases of congenital aplasia cutis with dermal melanocytosis

Uehara¹,

Hatano²,

Kato³

et al. 2011

The Journal of Dermatology

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“…The presence of melanizing signals in the epidermis of teleosts has been known for decades [ 52 ], but the underlying molecular mechanisms remain obscure. It seems plausible that invasion into the epidermis alters the availability of signals, possibly consisting of Wnt5a [ 53 ], and/or signals derived from intact or degraded ECM molecules such as laminin [ 54 ] or elastin [ 55 ], which in turn impinge on the regulation of Sox5 [ 56 ] and/or other regulators of melanophore differentiation.…”

Section: Discussionmentioning

confidence: 99%

Experimental Dissection of Metalloproteinase Inhibition-Mediated and Toxic Effects of Phenanthroline on Zebrafish Development

Ellis¹,

Crawford²

2016

IJMS

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Metalloproteinases are zinc-dependent endopeptidases that function as primary effectors of tissue remodeling, cell-signaling, and many other roles. Their regulation is ferociously complex, and is exquisitely sensitive to their molecular milieu, making in vivo studies challenging. Phenanthroline (PhN) is an inexpensive, broad-spectrum inhibitor of metalloproteinases that functions by chelating the catalytic zinc ion, however its use in vivo has been limited due to suspected off-target effects. PhN is very similar in structure to phenanthrene (PhE), a well-studied poly aromatic hydrocarbon (PAH) known to cause toxicity in aquatic animals by activating the aryl hydrocarbon receptor (AhR). We show that zebrafish are more sensitive to PhN than PhE, and that PhN causes a superset of the effects caused by PhE. Morpholino knock-down of the AhR rescues the effects of PhN that are shared with PhE, suggesting these are due to PAH toxicity. The effects of PhN that are not shared with PhE (specifically disruption of neural crest development and angiogenesis) involve processes known to depend on metalloproteinase activity. Furthermore these PhN-specific effects are not rescued by AhR knock-down, suggesting that these are bona fide effects of metalloproteinase inhibition, and that PhN can be used as a broad spectrum metalloproteinase inhibitor for studies with zebrafish in vivo.

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“…The chemotactic sites on elastin fragments contains lysyl-derived cross-links that recruit inflammatory cells to the lungs, resulting in elastase-induced emphysema 28 . In melanocyte precursors, VGVAPG stimulates melanogenesis and dendrite formation 29 . Finally, elastin fragments have pathologic roles in tumor migration, invasion, adhesion, and angiogenesis.…”

Section: Elastin Peptides As Matrikinesmentioning

confidence: 99%

MMP generated matrikines

2015

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Matrikines originate from the fragmentation of extracellular matrix proteins and regulate cellular activities by interacting with specific receptors. Matrikines are implicated in inflammation, immune responses, organ development, wound repair, angiogenesis, atherosclerosis, tumor progression and metastasis due to their ability to alter cellular migration, chemotaxis, and mitogenesis. Matrix metalloproteinases (MMPs) degrade extracellular matrix components under normal circumstances and in disease processes. Of the 20 MMPs identified, MMP-1, MMP-2, MMP-8, MMP-9, and MMP-12 have been implicated in regulating the matrikines val-gly-val-ala-pro-gly (elastin peptide) and proline-glycine-proline (PGP). Elastin peptide fragments are generated from elastolytic enzymes and have implications in atherosclerosis, neovascularization, chronic obstructive pulmonary disease, skin disease, as well as tumor invasion and spread. PGP is produced through a multistep pathway that liberates the tripeptide fragment from extracellular collagen. PGP is best described for its role in neutrophil chemotaxis and is implicated in the pathogenesis of corneal ulcers and in chronic lung conditions. In chronic cigarette smoke related lung disease, the PGP pathway can become a self-propagating cycle of inflammation through cigarette-smoke mediated inhibition of leukotriene A4 hydrolase, the enzyme responsible for degrading PGP and halting acute inflammation. This review highlights the roles of MMPs in generating these important matrikines.

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Melanocyte precursors express elastin binding protein and elastin-derived peptide (VGVAPG) stimulates their melanogenesis and dendrite formation

Cited by 20 publications

References 36 publications

Two cases of congenital aplasia cutis with dermal melanocytosis

Two cases of congenital aplasia cutis with dermal melanocytosis

Experimental Dissection of Metalloproteinase Inhibition-Mediated and Toxic Effects of Phenanthroline on Zebrafish Development

MMP generated matrikines

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