Melanized fungus as an Epidural abscess: A diagnostic and therapeutic challenge

Shrivastava, Adesh; Karuna, Tadepalli; Goel, Garima; Gupta, Kanishk; Gupta, Pradeep Kumar

doi:10.1016/j.mmcr.2017.04.001

Cited by 10 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 The pigmentation of dematiaceous fungi is associated with the presence of melanin in its cell wall, which acts as an important virulence factor in the development of fungal infections in humans, such as phaeohyphomycosis. 3 Ungual phaeohyphomycosis are examples of non-dermatophytic onychomycosis, responsible for 1.5% to 18% of the cases of these infections. 4,5 Phaeohyphomycosis have increased their incidence in humans, both in immunocompromised and immunocompetent individuals, 6 and cause nail disease presenting as changes in color, thickness, detachment and onychodystrophy.…”

Section: Introductionmentioning

confidence: 99%

In vitro Antifungal Susceptibility of Agents for Superficial Phaeohyphomycosis

Pagnussat

Machado

Scarton

2020

SPDV

View full text Add to dashboard Cite

The selection of fungal isolates resistant to available therapy associated with an increase in the number of immunosuppressed patients has contributed to the incidence of infections caused by dematiaceous fungi. Thus, this study evaluated the therapeutic efficacy of the main antifungal agents currently used in clinical practice in relation to Curvularia spp. and Hortaea werneckii from cases of superficial phaeohyphomycosis from southern Brazil. The susceptibility profile of amphotericin B, fluconazole, itraconazole, terbinafine and voriconazole against dematiaceous fungi (Curvularia lunata, C. pallescens and H. werneckii) was evaluated by microdilution in broth. Terbinafine showed greater efficacy against C. lunata - gemometric mean (GM = 0.38 μg/mL), C. pallescens (MIC = 0.125 μg/mL) and H. werneckii (GM = 0.031 μg/mL) when compared to the other antifungals tested. Most of species showed sensitivity to itraconazole and voriconazole, with a minimum inhibitory concentration (MIC) range from 1 - 8.0 μg/mL and 0.5 - 2.0 μg/mL, respectively. All isolates tested show low sensitivity to fluconazole (MIC range 4 - 16 μg/mL). Although itraconazole is considered gold standard, terbinafine has been showed to be a good alternative for the treatment of superficial phaeohyphomycosis. Lastly, antifungal susceptibility testing is essential to indicate the ideal therapy against these infections.

show abstract

Section: Introductionmentioning

confidence: 99%

In vitro Antifungal Susceptibility of Agents for Superficial Phaeohyphomycosis

Pagnussat

Machado

Scarton

2020

SPDV

View full text Add to dashboard Cite

show abstract

“…C. bantiana CNS infections have an estimated mortality rate of 70%, even with appropriate treatment. This is attributed to the need for diagnostic brain biopsy, which occurs late in the disease course and delays treatment (3). C. bantiana is a therapeutic challenge as optimal treatment is unknown because of the relative paucity of documented cases and variable outcomes in reported patients.…”

Section: Discussionmentioning

confidence: 99%

Double Vision and Gait Ataxia in an Immunocompetent 9-Year-Old Girl With Intracranial Phaeohyphomycosis

Pareek¹,

Lotze²,

Demmler³

et al. 2021

Journal of Neuro-Ophthalmology

View full text Add to dashboard Cite

A 9-year-old girl presented with morning headaches associated with vomiting, gait ataxia, and facial and ocular motor nerve palsies. Her initial imaging was concerning for demyelinating disease. After extensive infectious and rheumatologic workup returned negative, she was treated twice with intravenous immunoglobulin and intravenous steroids with near-complete resolution each time. She returned, however, with worsening neurologic deficits and imaging revealing focal ischemic infarction in the brainstem as well as new-onset hydrocephalus. A multispecialty workup was initiated without conclusive diagnosis. A novel, noninvasive test for plasma cell-free DNA established a diagnosis of Cladophialophora bantiana that was confirmed and validated by a brain biopsy taken during a clinical decompensation. Treatment was initiated with systemic voriconazole and intraventricular amphotericin B.

show abstract

“…include phaeohyphomycosis, nondermatophytic onychomycosis, mycetoma, and infections in eyes, nails, sinuses, and wounds (Vineetha et al, 2016). Infections generally occur through direct inoculation of conidia or by inhalation, leaving it susceptible for invasion (Shrivastava et al, 2017). Patients with peritoneal, venous catheters, intravenous drug abusers, and cataract surgery patients are more prone to C. lunata infections (Alex et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Molecular Level Atomistic and Structural Insights on Biological Macromolecules, Inhibition, and Dynamics Studies

2024

Frontiers Research Topics

View full text Add to dashboard Cite

Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

show abstract

Melanized fungus as an Epidural abscess: A diagnostic and therapeutic challenge

Cited by 10 publications

References 12 publications

In vitro Antifungal Susceptibility of Agents for Superficial Phaeohyphomycosis

In vitro Antifungal Susceptibility of Agents for Superficial Phaeohyphomycosis

Double Vision and Gait Ataxia in an Immunocompetent 9-Year-Old Girl With Intracranial Phaeohyphomycosis

Molecular Level Atomistic and Structural Insights on Biological Macromolecules, Inhibition, and Dynamics Studies

Contact Info

Product

Resources

About