Melanin pigments extracted from horsehair as antibacterial agents

Eliato, Tahmineh Rahmani; Smith, Joshua T.; Tian, Zhen; Kim, Eun-Sik; Hwang, Wonseok; Andam, Cheryl P.; Kim, Young Jo

doi:10.1039/d0tb02475a

Cited by 30 publications

(19 citation statements)

References 83 publications

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“…As a result, melanin is able to interact with aromatic metabolites or compositions of microorganisms through hydrogen bonds or π-π interactions ( 34 , 35 ). Another explanation for the anti-bacterial properties of melanin and its intermediates is that they contain high levels of redox-active catechol groups, which can produce reactive oxygen species under light and water stimulation ( 36 ). However, since the mucosal melanocytes are in a dark environment with marginal melanin production, it remains unknown whether the pigment levels in mucosal regions are sufficient for antimicrobial effects.…”

Section: Biological Functions Of Melanocytesmentioning

confidence: 99%

Mucosal Melanoma: Pathological Evolution, Pathway Dependency and Targeted Therapy

Xia

et al. 2021

Front. Oncol.

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Mucosal melanoma (MM) is a rare melanoma subtype that originates from melanocytes within sun-protected mucous membranes. Compared with cutaneous melanoma (CM), MM has worse prognosis and lacks effective treatment options. Moreover, the endogenous or exogenous risk factors that influence mucosal melanocyte transformation, as well as the identity of MM precursor lesions, are ambiguous. Consequently, there remains a lack of molecular markers that can be used for early diagnosis, and therefore better management, of MM. In this review, we first summarize the main functions of mucosal melanocytes. Then, using oral mucosal melanoma (OMM) as a model, we discuss the distinct pathologic stages from benign mucosal melanocytes to metastatic MM, mapping the possible evolutionary trajectories that correspond to MM initiation and progression. We highlight key areas of ambiguity during the genetic evolution of MM from its benign lesions, and the resolution of which could aid in the discovery of new biomarkers for MM detection and diagnosis. We outline the key pathways that are altered in MM, including the MAPK pathway, the PI3K/AKT pathway, cell cycle regulation, telomere maintenance, and the RNA maturation process, and discuss targeted therapy strategies for MM currently in use or under investigation.

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Section: Biological Functions Of Melanocytesmentioning

confidence: 99%

Mucosal Melanoma: Pathological Evolution, Pathway Dependency and Targeted Therapy

Xia

et al. 2021

Front. Oncol.

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“…This suggests that the naturally occurring melanin may serve as a promising antibacterial agent with unique redox chemistry and ROS generation capability. 28 However, poor adhesion with native substrates and uncontrollable topography are other challenges especially for coating or fabricating the composite. Therefore, synthesizing biologically derived redox active materials would be advantageous for developing more functional antibacterial agents.…”

mentioning

confidence: 99%

“…42 Eumelanins extracted from the horsehair have been previously studied to generate ROS by reversible oxidation from catechols to ortho -quinone, which were applied to completely reject both Gram-negative and Gram-positive bacteria within 4 hours of incubation under the aqueous media. 28…”

mentioning

confidence: 99%

“…Compared to the C–OH/CO bond of PPG at 533.2 eV, a higher density of C–OH/CO groups is considered to be present from PPG (45.99%) in comparison to Mel (40.10%). 28,48…”

mentioning

confidence: 99%

“…O 2 can be reduced by one electron to generate O 2 ˙ − (primary ROS), which can be converted into more stable H 2 O 2 (secondary ROS) by reacting with H + . 28,58,59 PPG and Mel were incubated in ddH 2 O under ambient light, and H 2 O 2 concentrations were monitored (Fig. 4(a)).…”

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confidence: 99%

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Synthesis of biologically derived poly(pyrogallol) nanofibers for antibacterial applications

Tian

Libby

et al. 2023

J. Mater. Chem. B

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D–A Structured High‐Performance Photothermal/Photodynamic Thionin‐Synthetic Melanin Nanoparticles for Rapid Bactericidal and Wound Healing Effects

Liu

Cheng

et al. 2023

Adv Healthcare Materials

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Synthesized melanin nanoparticles (SMNPs) are used as advanced photothermal materials. However, their internal structures are complex and disordered, and tuning the photothermal performance of nanoparticles is still a hot spot of concern. This article presents thionin (Th)‐doped SMNPs, namely Th‐SMNPs, which are the first SMNPs formed using the one‐pot polymerization of Th with Levodopa. Th can undergo Michael addition and Schiff base reaction between indole dihydroxy/indolequinone and their oligomers to form donor–acceptor pairs in the structure to modulate the photothermal performance of SMNPs. Structural and spectroscopic analyses and density functional theory simulations further confirm the existence of the donor–acceptor structure. Th‐SMNPs exhibit excellent total photothermal efficiency (34.49%) in the near‐infrared region (808 nm), which is a 60% improvement compared to SMNPs. This allows Th‐SMNPs to exhibit excellent photothermal performance at low power 808 nm laser irradiation. Meanwhile, Th not only enhances the photothermal properties of SMNPs, but also imparts photodynamic effects to SMNPs. Th‐SMNPs can produce 1O2 under 660 nm laser irradiation. A dual‐function photothermal and photodynamic textile named Th‐SMNPs@cotton is constructed based on Th‐SMNPs, which can act as a rapid photothermal/photodynamic sterilization and is promising for wound healing treatment of bacterial infections under low‐power dual laser irradiation.

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Melanin pigments extracted from horsehair as antibacterial agents

Abstract: Here we present the important findings related to biologically derived pigments for potential use as antibacterial agents. Melanin biopigments extracted from Equus ferus hair exhibit homogeneous elliptical microstructure with highly...

Cited by 30 publications

References 83 publications

Mucosal Melanoma: Pathological Evolution, Pathway Dependency and Targeted Therapy

Mucosal Melanoma: Pathological Evolution, Pathway Dependency and Targeted Therapy

Synthesis of biologically derived poly(pyrogallol) nanofibers for antibacterial applications

D–A Structured High‐Performance Photothermal/Photodynamic Thionin‐Synthetic Melanin Nanoparticles for Rapid Bactericidal and Wound Healing Effects

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