Melanin Pigmentation, Women, and Levodopa

Robins, Ashley H.

doi:10.1001/archderm.1979.04010070003006

Cited by 4 publications

(1 citation statement)

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“…Much has also been discussed about the possible relationship between this drug and malignant melanoma. Although there are no concluding data, levodopa has been said to induce the growth of melanoma or recurrences of this tumour 10–14 . So far we have not found in the literature references to the association between hyperpigmentation mimicking Laugier syndrome and treatment with levodopa.…”

Section: Discussionmentioning

confidence: 94%

Hyperpigmentation mimicking Laugier syndrome, levodopa therapy and Addison's disease

Gutiérrez¹,

Romero²,

Martínez³

et al. 2003

Acad Dermatol Venereol

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The Laugier-Hunziker syndrome is an acquired, idiopathic, benign mucocutaneous hypermelanosis that usually occurs on the lips and oral mucosa, although it may appear at other sites. Nails are frequently involved, mainly forming longitudinal hyperpigmented bands. We report the case of a patient that presented a typical picture of this entity, nearly 1 year after the beginning of treatment with levodopa. Two years after the first lesions occurred, she developed Addison's disease. The patient suffered from a diffuse discrete hyperpigmentation (it was more remarkable on exposed areas) and an intensification of the melanotic macules that were previously noticeable before in oral and genital mucosa, fingers, toes and nails. Hormonal replacement treatment enabled the control of laboratory and general manifestations and to decrease the degree of mucocutaneous hyperpigmentation considerably, despite initial hyperpigmented lesions persisting in described areas.

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Section: Discussionmentioning

confidence: 94%