Melanin‐Concentrating Hormone and Its <scp>MCH</scp>‐1 Receptor: Relationship Between Effects on Alcohol and Caloric Intake

Karlsson, Camilla; Aziz, Abdul Maruf Asif; Rehman, Faazal; Pitcairn, Caleb; Barchiesi, Riccardo; Barbier, Estelle; Hansen, Mikaela Wendel; Gehlert, D.R.; Steensland, Pia; Heilig, Markus; Thorsell, Annika

doi:10.1111/acer.13181

Cited by 7 publications

(5 citation statements)

References 39 publications

(57 reference statements)

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“…The exact mechanism by which this MCH modulation happens was, however, contentious, as some reports suggested that MCHR1 was not involved in the alcohol consumption-promoting effect of MCH (Duncan et al, 2006, 2007), while others found a potent decrease in alcohol consumption and reinstatement after an MCHR1 antagonist treatment (Cippitelli et al, 2010). Recently, Karlsson et al (2016) reported that MCH and MCHR1 have a dual role in the regulation of alcohol intake through mechanisms related both to caloric intake and reward motivation. Further experiments on MCH alterations linked to alcohol consumption, however, are still necessary to provide an overarching explanation for all results reported in the literature.…”

Section: Feeding Behaviormentioning

confidence: 99%

The Melanin-Concentrating Hormone as an Integrative Peptide Driving Motivated Behaviors

Diniz

Bittencourt

2017

Front. Syst. Neurosci.

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The melanin-concentrating hormone (MCH) is an important peptide implicated in the control of motivated behaviors. History, however, made this peptide first known for its participation in the control of skin pigmentation, from which its name derives. In addition to this peripheral role, MCH is strongly implicated in motivated behaviors, such as feeding, drinking, mating and, more recently, maternal behavior. It is suggested that MCH acts as an integrative peptide, converging sensory information and contributing to a general arousal of the organism. In this review, we will discuss the various aspects of energy homeostasis to which MCH has been associated to, focusing on the different inputs that feed the MCH peptidergic system with information regarding the homeostatic status of the organism and the exogenous sensory information that drives this system, as well as the outputs that allow MCH to act over a wide range of homeostatic and behavioral controls, highlighting the available morphological and hodological aspects that underlie these integrative actions. Besides the well-described role of MCH in feeding behavior, a prime example of hypothalamic-mediated integration, we will also examine those functions in which the participation of MCH has not yet been extensively characterized, including sexual, maternal, and defensive behaviors. We also evaluated the available data on the distribution of MCH and its function in the context of animals in their natural environment. Finally, we briefly comment on the evidence for MCH acting as a coordinator between different modalities of motivated behaviors, highlighting the most pressing open questions that are open for investigations and that could provide us with important insights about hypothalamic-dependent homeostatic integration.

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Section: Feeding Behaviormentioning

confidence: 99%

The Melanin-Concentrating Hormone as an Integrative Peptide Driving Motivated Behaviors

Diniz

Bittencourt

2017

Front. Syst. Neurosci.

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“…Notably, optogenetic activation of MCH neurons in mice induces sleep, but not food consumption (Konadhode et al, 2013). However, MCH signaling can promote motivational behaviors leading to overconsumption of highly-palatable, calorically-dense food (Georgescu et al, 2005) and is involved in stress-induced binge eating (Pankevich et al, 2010), as well as cocaine (Chung et al, 2009) and alcohol (Duncan et al, 2005; Karlsson et al, 2016a,b) consumption. The involvement of MCH in food intake in animals prompted investigation of potential therapeutic effects of MCH receptor (MCHR) antagonists as anti-obesity agents in humans, but currently no compounds have proceeded to Phase II studies (Macneil, 2013).…”

Section: Central Regulation Of Food Intake: the Interaction Of Orexigmentioning

confidence: 99%

Interactions of Circadian Rhythmicity, Stress and Orexigenic Neuropeptide Systems: Implications for Food Intake Control

et al. 2017

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Many physiological processes fluctuate throughout the day/night and daily fluctuations are observed in brain and peripheral levels of several hormones, neuropeptides and transmitters. In turn, mediators under the “control” of the “master biological clock” reciprocally influence its function. Dysregulation in the rhythmicity of hormone release as well as hormone receptor sensitivity and availability in different tissues, is a common risk-factor for multiple clinical conditions, including psychiatric and metabolic disorders. At the same time circadian rhythms remain in a strong, reciprocal interaction with the hypothalamic-pituitary-adrenal (HPA) axis. Recent findings point to a role of circadian disturbances and excessive stress in the development of obesity and related food consumption and metabolism abnormalities, which constitute a major health problem worldwide. Appetite, food intake and energy balance are under the influence of several brain neuropeptides, including the orexigenic agouti-related peptide, neuropeptide Y, orexin, melanin-concentrating hormone and relaxin-3. Importantly, orexigenic neuropeptide neurons remain under the control of the circadian timing system and are highly sensitive to various stressors, therefore the potential neuronal mechanisms through which disturbances in the daily rhythmicity and stress-related mediator levels contribute to food intake abnormalities rely on reciprocal interactions between these elements.

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“…The strong conservation of the MCH peptidergic system can be explained by the wide range of functions associated with MCH and NEI, which include but are not limited to: ingestive behavior (Georgescu et al, ; Ludwig et al, ; Qu et al, ), energy expenditure (Guesdon, Paradis, Samson, & Richard, ; Segal‐Lieberman et al, ; Shimada, Tritos, Lowell, Flier, & Maratos‐Flier, ), reward (Domingos et al, ; Karlsson et al, ; Mul et al, ), sensory integration (Adams et al, ; Miller, Hruby, Matsunaga, & Bickford, ; Sita, Diniz, Canteras, Xavier, & Bittencourt, ), sleep (Lagos, Torterolo, Jantos, Chase, & Monti, ; Tsunematsu et al, ; Verret et al, ), stress response (Kennedy et al, ; Smith et al, ; Smith et al, ), learning (Adamantidis et al, ; Le Barillier et al, ; Monzon et al, ), sexual physiology (Gonzalez, Vaziri, & Wilson, ; Murray et al, ; Murray et al, ), and maternal physiology (Alachkar et al, ; Benedetto, Pereira, Ferreira, & Torterolo, ; Parkes & Vale, ). As a unifying theory for those functions, we recently proposed that MCH is a homeostatic maintainer, or metabolic dampener, acting to avoid large fluctuations from the baseline by integrating external and internal inputs, and organizing an appropriate response (Diniz & Bittencourt, ).…”

Section: Introductionmentioning

confidence: 99%

Melanin‐concentrating hormone peptidergic system: Comparative morphology between muroid species

Diniz

Battagello

Cherubini

et al. 2019

J of Comparative Neurology

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Melanin-concentrating hormone (MCH) is a conserved neuropeptide, predominantly located in the diencephalon of vertebrates, and associated with a wide range of functions. While functional studies have focused on the use of the traditional mouse laboratory model, critical gaps exist in our understanding of the morphology of the MCH system in this species. Even less is known about the nontraditional animal model Neotomodon alstoni (Mexican volcano mouse). A comparative morphological study among these rodents may, therefore, contribute to a better understanding of the evolution of the MCH peptidergic system. To this end, we employed diverse immunohistochemical protocols to identify key aspects of the MCH system, including its spatial relationship to another neurochemical population of the tuberal hypothalamus, the orexins. Three-dimensional (3D) reconstructions were also employed to convey a better sense of spatial distribution to these neurons. Our results show that the distribution of MCH neurons in all rodents studied follows a basic plan, but individual characteristics are found for each species, such as the preeminence of a periventricular group only in the rat, the lack of posterior groups in the mouse, and the extensive presence of MCH neurons in the anterior hypothalamic area of Neotomodon. Taken together, these data suggest a strong anatomical substrate for previously described functions of the MCH system, and that particular neurochemical

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Melanin‐Concentrating Hormone and Its MCH‐1 Receptor: Relationship Between Effects on Alcohol and Caloric Intake

Cited by 7 publications

References 39 publications

The Melanin-Concentrating Hormone as an Integrative Peptide Driving Motivated Behaviors

The Melanin-Concentrating Hormone as an Integrative Peptide Driving Motivated Behaviors

Interactions of Circadian Rhythmicity, Stress and Orexigenic Neuropeptide Systems: Implications for Food Intake Control

Melanin‐concentrating hormone peptidergic system: Comparative morphology between muroid species

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