Melanin Affinity of Manganese

Lydén, Annika; Larsson, Bengt; Lindquist, Nils Gunnar

doi:10.1111/j.1600-0773.1984.tb01975.x

Cited by 70 publications

(35 citation statements)

References 21 publications

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“…[40] Its role in the accumulation and release of metal cations in vivo, such as Prospective Article calcium, [7,41] copper, [42] zinc, [42,43] manganese, [44] iron, and other metals, [42,45,46] has received great attention, too. The uranyl oxycation has been used to reveal, by scanning electron microscopy (SEM), the presence of eumelanin deposited on carbon-based electrodes in supercapacitors.…”

Section: Introductionmentioning

confidence: 99%

Natural melanin pigments and their interfaces with metal ions and oxides: emerging concepts and technologies

Mauro

Soliveri

et al. 2017

MRS Communications

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Melanin (from the Greek μέλας, mélas, black) is a biopigment ubiquitous in flora and fauna, featuring broadband optical absorption, hydration-dependent electrical response, ion-binding affinity as well as antioxidative and radical-scavenging properties. In the human body, photoprotection in the skin and ion flux regulation in the brain are some biofunctional roles played by melanin. Here we discuss the progress in melanin research that underpins emerging technologies in energy storage/conversion, ion separation/water treatment, sunscreens, and bioelectronics. The melanin research aims at developing approaches to explore natural materials, well beyond melanin, which might serve as a prototype benign material for sustainable technologies.

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Section: Introductionmentioning

confidence: 99%

Natural melanin pigments and their interfaces with metal ions and oxides: emerging concepts and technologies

Mauro

Soliveri

et al. 2017

MRS Communications

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“…16,17 The functional groups associated with these molecular building blocks are central to the metal coordinating abilities exhibited by melanins. 4,7,[18][19][20] In situ, with the exception of NM, melanin is generally deposited in melanosomes, specialized organelles in pigment generating cells. Similar to most cellular organelles, melanosomes are membrane-bound structures containing a variety of molecular species, including lipids, proteins, and melanin.…”

Section: Introductionmentioning

confidence: 99%

Current Understanding of the Binding Sites, Capacity, Affinity, and Biological Significance of Metals in Melanin

2007

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Metal chelation is often invoked as one of the main biological functions of melanin. In order to understand the interaction between metals and melanin, extensive studies have been carried out to determine the nature of the metal binding sites, binding capacity and affinity. These data are central to efforts aimed at elucidating the role metal binding plays in determining the physical, structural, biological, and photochemical properties of melanin. This article examines the current state of understanding of this field.

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“…In contrast, rats do not demonstrate selective manganese accumulation in the striatum (8). Another possible explanation for this primate-selective effect is the observation that manganese has a high affinity for neuromelanin and that its deposition is highest in melanin-containing tissues (39). Neuromelanin levels increase considerably with higher phylogeny, and brain levels are highest in the primate brain regions in which the dopaminergic pathways are most active (41 Studies with MPTP have demonstrated that astrocytes play a critical role in neuronal injury through their ability to convert innocuous compounds into a toxic metabolite (16).…”

Section: Introductionmentioning

confidence: 99%

An Integrative Approach to Neurotoxicology

Dorman

2000

Toxicol Pathol

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Exposure of human populations to a wide variety of chemicals has generated concern about the potential neurotoxicity of new and existing chemicals. Experimental studies conducted in laboratory animals remain critical to the study of neurotoxicity. An integrative approach using pharmacokinetic, neuropathological, neurochemical, electrophysiological, and behavioral methods is needed to determine whether a chemical is neurotoxic. There are a number of factors that can affect the outcome of a neurotoxicity study, including the choice of animal species, dose and dosage regimen, route of administration, and the intrinsic sensitivity of the nervous system to the test chemical. The neurotoxicity of a chemical can vary at different stages of brain development and maturity. Evidence of neurotoxicity may be highly subjective and species specific and can be complicated by the presence of systemic disease. The aim of this paper is to give an overview of these and other factors involved in the assessment of the neurotoxic potential for chemicals. This article discusses the neurotoxicity of several neurotoxicants (eg, acrylamide, trimethyltin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, manganese, and ivermectin), thereby highlighting a multidisciplinary approach to the assessment of chemically induced neurotoxicity in animals. These model chemicals produce a broad range of effects that includes peripheral axonopathy, selective neuronal damage within the nervous system, and impaired neuronal-glial metabolism.

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Melanin Affinity of Manganese

Cited by 70 publications

References 21 publications

Natural melanin pigments and their interfaces with metal ions and oxides: emerging concepts and technologies

Natural melanin pigments and their interfaces with metal ions and oxides: emerging concepts and technologies

Current Understanding of the Binding Sites, Capacity, Affinity, and Biological Significance of Metals in Melanin

An Integrative Approach to Neurotoxicology

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