Mélanges industriels de nutrition parentérale en pédiatrie : faisabilité en nutrition parentérale à domicile

Could Commercial Formulations Replace Individualized Prescription in Pediatric Home Parenteral Nutrition?

“…The most common diagnosis in our population was SBS (58%). This remains the most common indication for home PN in the pediatric age group (3,5,16). These patients often have stomas and significant gastrointestinal fluid losses, increasing their requirements for water and electrolytes, particularly sodium.…”

“…We aimed to evaluate the possibility of replacing individually tailored prescription with commercially available standard PN formulations in a population of pediatric patients on home PN. For that purpose, we performed a quantitative analysis using three successive criteria (NPC:volume ratio, NPC:N ratio and electrolyte concentration), as previously described by Quessada et al (16). In a study by Foulmann et al, these same criteria were also defined as fundamental when choosing an adequate standard PN formulation in an adult population (19).…”

“…evaluating the safety and efficacy of standard solutions on this population are lacking (5,7,10,15,16).…”

“…The longer shelf life and increased availability of commercial PN solutions could therefore help reduce the frequency of PN bag deliveries (5,7,15). Additionally, it seems to decrease hospital pharmacies' workload and costs (7,14,16).…”

“…Each prescription was then compared with available commercial PN solutions using three successive criteria: non-protein calories to volume ratio (NPC:volume ratio); non-protein calories to nitrogen ratio (NPC:N ratio); electrolyte concentration (sodium, potassium, calcium, magnesium and phosphorus). These criteria have previously been used in similar studies (16). We considered the possibility of short term (<4 weeks) and long-term use (>4 weeks).…”