Melaleuca leucadendron (L.) L. flower extract exhibits antioxidant and photoprotective activities in human keratinocytes exposed to ultraviolet B radiation

Silva, Luan Silvestro Bianchini; Perasoli, Fernanda Barçante; Carvalho, Karen Vitor; Vieira, Karla Murata; Lopes, Míriam Teresa Paz; Souza, Gustavo Henrique Bianco de; Santos, Orlando David Henrique dos; Freitas, Kátia Michelle

doi:10.1016/j.freeradbiomed.2020.07.022

Cited by 14 publications

(5 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to the direct ROS-scavenging activity, endogenous antioxidases, like SOD and CAT, also play a vital role in protecting the skin against excessive ROS for maintaining the balance of the redox state. 49 Previous data from studies with skin cells, 50 as well as our result (Figure 4D,E), showed UV stimulus decreased the activity of SOD and CAT. This oxidative imbalance was reversed by AEO and CHA treatment as the activity of SOD and CAT increased to some extent and the level of MDA, a toxic lipid peroxidation product, decreased.…”

Section: ■ Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 72%

“…In the present time, chemical sunscreens, which are composed of synthetic small-molecule substances, account for 80% of commercial sunscreens . Due to their inadequate protection against UV, as well as their side effects on marine ecosystems and human health, there has been growing interest in developing natural substitutions to chemical sunscreens. , Botanical antioxidants can act as natural chemophotoprotectors with the potential to neutralize ROS production while also enhancing the endogenous antioxidant capacity of the skin . CHA attenuated ROS accumulation in bovine aortic endothelial cells exposed to either high glucose or H 2 O 2 stress .…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Artemisia sieversiana Ehrhart ex Willd. Essential Oil and Its Main Component, Chamazulene: Their Photoprotective Effect against UVB-Induced Cellular Damage and Potential as Novel Natural Sunscreen Additives

Zhou,

He,

Wang

et al. 2023

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

Section: ■ Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Artemisia sieversiana Ehrhart ex Willd. Essential Oil and Its Main Component, Chamazulene: Their Photoprotective Effect against UVB-Induced Cellular Damage and Potential as Novel Natural Sunscreen Additives

Zhou,

He,

Wang

et al. 2023

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

“…The production of ROS in significant amounts arises from UVB-induced oxidative stress-initiated inflammation-mediated skin aging. UVB-mediated skin damage is correlated with the production of proinflammatory cytokines and certain inflammatory enzymes, such as TNF-α, IL-6, IL-8, COX-2, and iNOS [ 42 ]. In accordance with our experimental data, we have confirmed that the expression levels of IL-6, IL-8, COX-2, and iNOS were markedly increased after UVB irradiation in HaCaT cells and were successfully inhibited by treatment with HC-EA.…”

Section: Discussionmentioning

confidence: 99%

Hyperoside and Quercitrin in Houttuynia cordata Extract Attenuate UVB-Induced Human Keratinocyte Cell Damage and Oxidative Stress via Modulation of MAPKs and Akt Signaling Pathway

et al. 2022

View full text Add to dashboard Cite

Ultraviolet radiation is a major environmental harmful factor on human skin. In this paper, we investigate the potential mechanism of Houttuynia cordata extract on UVB-induced HaCaT keratinocyte cell death and inflammation. We found that Houttuynia cordata ethyl acetate extract fraction (HC-EA) protected against UVB-induced cell damage. The HPLC results indicate that quercitrin and hyperoside are the major polyphenolics in HC-EA and are responsible for providing protection against UVB-induced cell death. These responses were associated with the regulation of caspase-9 and caspase-3 activation, which rescued HaCaT cells from UVB-induced apoptosis. In addition, HC-EA, quercitrin, and hyperoside attenuated UVB-induced inflammatory mediators, including IL-6, IL-8, COX-2, and iNOS. Furthermore, the treatment of cells with HC-EA and its active compounds abolished intracellular ROS and increased levels of heme oxygenase-1 and superoxide dismutase. UVB-induced ROS production mediated Akt and mitogen activated protein kinases (MAPKs) pathways, including p38, ERK, and JNK. Our results show HC-EA, quercitrin, and hyperoside decreased UVB-induced p38 and JNK phosphorylation, while increasing ERK and Akt phosphorylation. MAPKs and Akt mediated cell survival and death were confirmed by specific inhibitors to Akt and MAPKs. Thus, HC-EA, which contains quercitrin and hyperoside, protected keratinocyte from UVB-induced oxidative damage and inflammation through the modulation of MAPKs and Akt signaling.

show abstract

“…Essential oil and extracts derived from leaves of M. leucadendra demonstrated a series of biological activities of interest, including antioxidant, antimicrobial, antitumoral, and anti-inflammatory properties [8,12,14,22]. Phe-nolic acids, tannins, and flavonoids have been identified as the main ones responsible for the biological effects described for this species [5,19].…”

mentioning

confidence: 99%

Antibacterial Properties of Commercially Available Cayeput Essential Oil Against Different Gram-Positive and Gram-Negative Bacteria

Stefanowski

Tkachenko

Kurhaluk

et al. 2022

STBIAS

View full text Add to dashboard Cite

Essential oil and leaf extracts of Melaleuca leucadendra L. demonstrated a series of biological activities of interest, including antioxidant, antimicrobial, antitumoral and anti-inflammatory properties. The aim of the current study was an in vitro evaluation of the antimicrobial activity of the cajeput essential oil against Gram-negative strains such as Escherichia coli (Migula) Castellani and Chalmers (ATCC® 25922™), Escherichia coli (Migula) Castellani and Chalmers (ATCC® 35218™), Pseudomonas aeruginosa (Schroeter) Migula (ATCC® 27853™) and Gram-positive strains such as Staphylococcus aureus subsp. aureus Rosenbach (ATCC® 29213™), Staphylococcus aureus subsp. aureus Rosenbach (ATCC® 25923™), methicillin-resistant (MRSA), mecA positive Staphylococcus aureus (NCTC® 12493), Enterococcus faecalis (Andrewes and Horder) Schleifer and Kilpper-Balz (ATCC® 51299™) (resistant to vancomycin; sensitive to teicoplanin) and Enterococcus faecalis (Andrewes and Horder) Schleifer and Kilpper-Balz (ATCC® 29212™) to assess the possible use of this oil in preventing infections caused by these pathogens. The cajeput essential oil was provided by Polish essential oil manufacturers (Bamer®, Włocławek, Poland). Antimicrobial susceptibility of the tested strains was performed by the Kirby-Bauer disc diffusion method. Our research has shown that cajeput essential oil exhibits antibacterial properties. Gram-positive bacteria were the most susceptible to commercial cajeput oil, which may indicate that the active biological substances in cajeput essential oil (including phenolic acids, tannins, etc.) may be potential agents against bacterial infections. Among Gram-negative bacteria, only Pseudomonas aeruginosa (Schroeter) Migula (ATCC® 27853™) strain was resistant to the cajeput essential oil. We did not observe statistically significant changes in the zone of growth inhibition after the application of cajeput essential oil compared to the control samples (96% ethanol). Our study may suggest that the use of cajeput essential oil may be helpful for a wide range of bacterial infections in veterinary, aquaculture, medicine, and beyond.

show abstract

Melaleuca leucadendron (L.) L. flower extract exhibits antioxidant and photoprotective activities in human keratinocytes exposed to ultraviolet B radiation

Cited by 14 publications

References 73 publications

Artemisia sieversiana Ehrhart ex Willd. Essential Oil and Its Main Component, Chamazulene: Their Photoprotective Effect against UVB-Induced Cellular Damage and Potential as Novel Natural Sunscreen Additives

Artemisia sieversiana Ehrhart ex Willd. Essential Oil and Its Main Component, Chamazulene: Their Photoprotective Effect against UVB-Induced Cellular Damage and Potential as Novel Natural Sunscreen Additives

Hyperoside and Quercitrin in Houttuynia cordata Extract Attenuate UVB-Induced Human Keratinocyte Cell Damage and Oxidative Stress via Modulation of MAPKs and Akt Signaling Pathway

Antibacterial Properties of Commercially Available Cayeput Essential Oil Against Different Gram-Positive and Gram-Negative Bacteria

Contact Info

Product

Resources

About