mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity.

Kanno, Masamoto; Hasegawa, Masayuki; Ishida, Atsushi; Isono, Kaichi; Taniguchi, Masaru

doi:10.1002/j.1460-2075.1995.tb00254.x

Cited by 121 publications

(89 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The link between other PcG genes and cancer is less well established. Mel18 has been suggested to act as a tumor suppressor gene (Kanno et al, 1995), Rae28/Ph1 alterations are observed in acute lymphoblastic leukemia (Tokimasa et al, 2001) and SUZ12 is upregulated in colon tumors (Kirmizis et al, 2003). As regards Pc genes, no specific data exist although Pc2/CBX4 is considered a putative tumor suppressor (Satijn et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus

Bernard¹,

et al. 2005

View full text Add to dashboard Cite

Control of cell proliferation by Polycomb group proteins (PcG) is an important facet of cellular homeostasis and its disruption can promote tumorigenesis. We recently described CBX7 as a novel PcG protein controlling the growth of normal cells. In an attempt to identify a putative role of CBX7 in tumorigenesis, we analysed CBX7 expression in a panel of cancer cell lines and primary tissues. CBX7 was highly expressed in three different prostate cancer cell lines and present at elevated levels in normal prostate. Ablation of CBX7 expression using short hairpin RNAs (shRNA) resulted in upregulation of p16 Ink4a and p14 Arf in both LNCaP and PC-3 prostate cell lines. CBX7 knockdown caused an impairment of cell growth that was dependent on the status of the p14 Arf /p53 and p16 Ink4a /Rb pathways in both normal and cancer prostate cells. CBX7 overexpression in LNCaP cells resulted in a slight growth advantage in both androgen-dependent andindependent conditions. Moreover, CBX7 expression cooperated with c-Myc in rendering LNCaP cells insensitive to growth arrest by androgen receptor inhibition. Together, these data suggest that CBX7 represses p16 Ink4a and p14 Arf expression in normal and tumor-derived prostate cells, affecting their growth depending on the status of the p16 Ink4a /Rb and the p14 Arf /p53 pathways.

show abstract

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus

Bernard¹,

et al. 2005

View full text Add to dashboard Cite

show abstract

“…However, it has been reported that the related Mel 18 RING finger is essential for DNA binding (Tagawa et al 1990). Furthermore, it was shown recently that Mel 18 binds to a GACTNGACT target DNA sequence using a random oligonucleotide assay (Kanno et al 1995). Although Bmil has DNA-binding activity (M. Alkema, unpubl.…”

Section: Ventral View Of Thoracic Region Of a Wild-type [E] E]i-bmmentioning

confidence: 99%

Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex.

Alkema¹,

Bronk²,

Verhoeven³

et al. 1997

Genes Dev.

225

183

View full text Add to dashboard Cite

“…This locus encodes two proteins, p16 INK4a and p19 ARF , which regulate cellular proliferation and apoptosis. Only a few PcG proteins have been reported to bind DNA directly including Mel-18 and YY1 (Kanno et al, 1995;Brown et al, 1998). These proteins cannot account for all the Polycomb DNA binding activity, suggesting that other DNA binding factors may facilitate the recruitment of PcG complexes to specific promoters.…”

Section: Introductionmentioning

confidence: 99%

E2f6 and Bmi1 cooperate in axial skeletal development

Courel

Friesenhahn

Lees

2008

Developmental Dynamics

View full text Add to dashboard Cite

Bmi1 is a Polycomb Group protein that functions as a component of Polycomb Repressive Complex 1 (PRC1)to control axial skeleton development through Hox gene repression. Bmi1 also represses transcription of the Ink4a-Arf locus and is consequently required to maintain the proliferative and self-renewal properties of hematopoietic and neural stem cells. Previously, one E2F family member, E2F6, has been shown to interact with Bmi1 and other known PRC1 components. However, the biological relevance of this interaction is unknown. In this study, we use mouse models to investigate the interplay between E2F6 and Bmi1. This analysis shows that E2f6 and Bmi1 cooperate in the regulation of Hox genes, and consequently axial skeleton development, but not in the repression of the Ink4a-Arf locus. These findings underscore the significance of the E2F6 -Bmi1 interaction in vivo and suggest that the Hox and Ink4a-Arf loci are regulated by somewhat different mechanisms.

show abstract

mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity.

Cited by 121 publications

References 36 publications

RETRACTED ARTICLE: CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus

RETRACTED ARTICLE: CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus

Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex.

E2f6 and Bmi1 cooperate in axial skeletal development

Contact Info

Product

Resources

About