MEK-inhibitor treatment reduces the induction of regulatory T cells in mice after influenza A virus infection
Julia Koch-Heier,
Annette B. Vogel,
Yvonne Füll
et al.
Abstract:Regulatory T cells (Tregs) play a crucial and complex role in balancing the immune response to viral infection. Primarily, they serve to regulate the immune response by limiting the expression of proinflammatory cytokines, reducing inflammation in infected tissue, and limiting virus-specific T cell responses. But excessive activity of Tregs can also be detrimental and hinder the ability to effectively clear viral infection, leading to prolonged disease and potential worsening of disease severity. Not much is k… Show more
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