Mejoría en el pronóstico de la leucemia linfoblástica aguda en niños de un país en desarrollo: Resultados del protocolo nacional chileno PINDA 87

Relapse of childhood acute lymphoblastic leukemia and outcomes at a reference center in Latin America: organomegaly at diagnosis is a significant clinical predictor

“…Remarkably, T-cell ALL incidence was under 5% in our group, this is less than half the 12.4% found in children from Mexico City [3] and also lower than 10% in Chilean patients [30]; this could be partially be explained by geographical variation in ALL biologic subtype distribution, as our ethnic composition in considerable different from the center and south regions of the country.…”

“…HR for death (s OS) and treatment failure (-f EFS) according to uni-and multivariate Cox's proportional regression analysis for ALL in children and its association with clinical and laboratory characteristics. whereas in 444 Chilean patients relapse rate according to risk classification at diagnosis was 16-24%, with isolated CNS relapse in 5.4% children [30]. In this last study, a statistically significant difference according to the use or not of high doses of MTX as a risk factor for relapse was found.…”

Frecuencia de los genes de fusión TEL/AML1 y BCR/ABL en pacientes pediátricos con leucemia linfoblástica aguda

“…En general, podemos comentar que aunque nuestro grupo de estudio fue pequeño y el tiempo de seguimiento corto, la SLE estimada a 40 meses del total de los niños con LLA es similar a los resultados publicados del protocolo nacional chileno LLA PINDA 87 (SLE a 5 años de 60%) 46 .…”