MEIS and PBX homeobox proteins in ovarian cancer

Crijns, Anne; Graeff, Pauline de; Geerts, Dirk; Hoor, Klaske A. ten; Hollema, Harmen; Sluis, Tineke van der; Hofstra, Robert; Bock, de Truuske; Jong, de Steven; Zee, van der Ate; Vries, de Elisabeth G. E.

doi:10.1016/j.ejca.2007.08.025

Cited by 85 publications

(79 citation statements)

References 40 publications

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“…Whereas Meis3 expression was detectable, the levels of Meis1 and Meis2 expression were dramatically higher (Fig. 4A), consistent with previous reports that showed Meis1 is the highest expressed homeodomain factor in ovarian cancer cells compared with other cancer types (8). siRNA-mediated silencing of Meis3 was performed in the ID8 cells.…”

Section: Meis3 Is the Predominant Meis Family Member Expressed In Pansupporting

confidence: 78%

“…The mammalian Meis (myeloid ecotropic viral insertion site) genes were first identified in a murine leukemia model (7). Subsequent studies report that Meis proteins are extensively expressed in a large set of ovarian carcinomas and neuroblastoma (8,9). Further, Meis1 and Meis2 are expressed in 10 different "cancer modules" within gene expression profiles of 22 diverse tumor types, raising the expectation that more data on Meis members in oncogenesis will emerge (10).…”

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confidence: 99%

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Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1

Liu

Wang²,

Birnbaum³

2010

Proc. Natl. Acad. Sci. U.S.A.

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Three-amino-acid-loop-extension (TALE) homeodomain proteins including Meis and Pbx families are generally recognized for their roles in growth and differentiation during vertebrate embryogenesis and tumorigenesis. Whereas genetic studies indicate that Pbx1 regulates the development and function of insulin-producing pancreatic β-cells, the role of Meis family members in β-cells is still unknown. Here we show that Meis3 is abundantly expressed in pancreatic islets and β-cells and that it regulates β-cell survival. We further identify the 3-phosphoinositide-dependent protein kinase 1 (PDK1), a well-known kinase involved in the PI3K-Akt signaling pathway, as a direct Meis3 target, which mediates its role in β-cell survival. This regulatory module appears to function broadly as we also identify Meis3 regulation of cell survival and PDK1 expression in ovarian carcinoma cells, suggesting a unique function for Meis3 beyond the traditional roles for TALE homeodomain factors during embryogenesis.diabetes | transcription | pancreas | apoptosis

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Section: Meis3 Is the Predominant Meis Family Member Expressed In Pansupporting

confidence: 78%

mentioning

confidence: 99%

Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1

Liu

Wang²,

Birnbaum³

2010

Proc. Natl. Acad. Sci. U.S.A.

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“…Meis2 maps to human chromosome 15 ( 36 ), but, except for its involvement in developmental processes and cancer (37)(38)(39), not much is known about the function of this transcription factor. Although our transfection experiments revealed that Meis2d acts as a positive regulator of both the hepatic and intestinal SOAT2 expression ( Fig.…”

Section: Discussionmentioning

confidence: 99%

TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2

Pramfalk

Melhuish

Wotton

et al. 2014

Journal of Lipid Research

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“…Key roles of this transcription factor are now documented both in normal development and disease formation (1)(2)(3)(4). Decreased MEIS1 levels are associated with Restless leg syndrome (RLS) (5,6).…”

Section: Introductionmentioning

confidence: 99%

Identification of E74-like factor 1 (ELF1) as a transcriptional regulator of the Hox cofactor MEIS1

Xiang

Argiropoulos

et al. 2010

Experimental Hematology

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Objective-MEIS1 is a Hox cofactor known for its role in development and strongly linked to normal and leukemic hematopoiesis. Although previous studies have focused on identifying protein partners of MEIS1 and its transcriptionaly regulated targets, little is known about the upstream transcriptional regulators of this tightly regulated gene. Understanding the regulation of MEIS1 is important toward the understanding of normal hematopoiesis and leukemogenesis.Materials and Methods-Here we describe our studies focusing on the evolutionary conserved putative MEIS1 promoter region. Phylogenetic sequence analysis followed and reporter assays in MEIS1 expressing (K562) and non-expressing (HL60) leukemic cell line models were used to identify key regulatory regions and potential transcription factor binding sites within the candidate promoter region followed by functional and expression studies of one identified regulator in both cell lines and primary human cord blood and leukemia samples. Results-The chromatin status of MEIS1 promoter region is associated with MEIS1 expression.Truncation and mutation studies coupled with reporter assays revealed that a conserved ETS family member binding site located 289bp upstream of the annotated human MEIS1 transcription start site (AHTSS) is required for promoter activity. Of the three ETS family members tested, only ELF1 was enriched on the MEIS1 promoter as assessed by both electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP) experiments in K562. This finding was confirmed in MEIS1 expressing primary human samples. Moreover, siRNA -mediated knockdown of ELF1 in K562 cells was associated with a decreased MEIS1 expression.Conclusions-We conclude that the ETS transcription factor ELF1 is an important positive regulator of MEIS1 expression.

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MEIS and PBX homeobox proteins in ovarian cancer

Cited by 85 publications

References 40 publications

Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1

Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1

TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2

Identification of E74-like factor 1 (ELF1) as a transcriptional regulator of the Hox cofactor MEIS1

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