Meiotic drive in mice carrying t-complex in their genome

Safronova, L. D.; Chubykin, V. L.

doi:10.1134/s1022795413060094

Cited by 7 publications

(10 citation statements)

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“…The other common form of segregation distortion, “gamete killing” drive, occurs post-meiotically but before fertilization and features destruction or functional disruption of gametes lacking the drive element, as orchestrated by the element [ 3 , 8 ]. This form of distortion usually is associated with male gametogenesis, presumably because drive-induced loss of functional gametes normally entails lower fecundity costs to males than females [ 6 , 17 , 18 ]; while male gamete killing drive appears to be the most common form of segregation distortion, ascertainment bias may make it appear so simply because it usually produces altered sex-ratios and therefore is readily detected [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Transmission ratio distortion increasingly is viewed as an important evolutionary force driving such diverse phenomena as the origin of meiotic asymmetries in oogenesis [ 19 ], the dynamics of chromosomal architecture [ 20 ], mating system evolution [ 6 , 21 – 23 ], speciation [ 3 , 9 , 24 ], and extinction [ 25 ]. Notably, though, TRD appears to have only a sporadic taxonomic distribution and often seems poorly developed or rare in those wild populations in which it has been reported [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Unexpected patterns of segregation distortion at a selfish supergene in the fire ant Solenopsis invicta

Ross

Shoemaker

2018

BMC Genet

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BackgroundThe Sb supergene in the fire ant Solenopsis invicta determines the form of colony social organization, with colonies whose inhabitants bear the element containing multiple reproductive queens and colonies lacking it containing only a single queen. Several features of this supergene — including suppressed recombination, presence of deleterious mutations, association with a large centromere, and “green-beard” behavior — suggest that it may be a selfish genetic element that engages in transmission ratio distortion (TRD), defined as significant departures in progeny allele frequencies from Mendelian inheritance ratios. We tested this possibility by surveying segregation ratios in embryo progenies of 101 queens of the “polygyne” social form (3512 embryos) using three supergene-linked markers and twelve markers outside the supergene.ResultsSignificant departures from Mendelian ratios were observed at the supergene loci in 3–5 times more progenies than expected in the absence of TRD and than found, on average, among non-supergene loci. Also, supergene loci displayed the greatest mean deviations from Mendelian ratios among all study loci, although these typically were modest. A surprising feature of the observed inter-progeny variation in TRD was that significant deviations involved not only excesses of supergene alleles but also similarly frequent excesses of the alternate alleles on the homologous chromosome. As expected given the common occurrence of such “drive reversal” in this system, alleles associated with the supergene gain no consistent transmission advantage over their alternate alleles at the population level. Finally, we observed low levels of recombination and incomplete gametic disequilibrium across the supergene, including between adjacent markers within a single inversion.ConclusionsOur data confirm the prediction that the Sb supergene is a selfish genetic element capable of biasing its own transmission during reproduction, yet counterselection for suppressor loci evidently has produced an evolutionary stalemate in TRD between the variant homologous haplotypes on the “social chromosome”. Evidence implicates prezygotic segregation distortion as responsible for the TRD we document, with “true” meiotic drive the most likely mechanism. Low levels of recombination and incomplete gametic disequilibrium across the supergene suggest that selection does not preserve a single uniform supergene haplotype responsible for inducing polygyny.Electronic supplementary materialThe online version of this article (10.1186/s12863-018-0685-9) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Unexpected patterns of segregation distortion at a selfish supergene in the fire ant Solenopsis invicta

Ross

Shoemaker

2018

BMC Genet

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“…Although putative population crashes caused by meiotic drive have occasionally been reported (Pinzone and Dyer ), meiotic drive has often been found in nature at stable, intermediate frequencies over wide geographic areas and long periods of time (Dobzhansky ; Huang et al ; Dyer ). What maintains polymorphisms for meiotic drive (i.e., coexistence of driving and nondriving chromosomes or alleles) is therefore a longstanding puzzle, as is the lower than expected frequency of drive in some natural populations (e.g., Lewontin ; Charlesworth and Hartl ; Taylor and Jaenike ; Safronova and Chubykin ; Auclair et al ).…”

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confidence: 99%

Coevolutionary dynamics of polyandry and sex-linked meiotic drive

et al. 2015

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Segregation distorters located on sex chromosomes are predicted to sweep to fixation and cause extinction via a shortage of one sex, but in nature they are often found at low, stable frequencies. One potential resolution to this longstanding puzzle involves female multiple mating (polyandry). Because many meiotic drivers severely reduce the sperm competitive ability of their male carriers, females are predicted to evolve more frequent polyandry and thereby promote sperm competition when a meiotic driver invades. Consequently, the driving chromosome's relative fitness should decline, halting or reversing its spread. We used formal modeling to show that this initially appealing hypothesis cannot resolve the puzzle alone: other selective pressures (e.g., low fitness of drive homozygotes) are required to establish a stable meiotic drive polymorphism. However, polyandry and meiotic drive can strongly affect one another's frequency, and polyandrous populations may be resistant to the invasion of rare drive mutants.

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“…Reproductive failure and individual survival are complex traits and hence may be influenced by multiple genetic components that can be evolutionary stable. For instance, reproductive failure and mortality may be caused by selfish genetic elements that are self-promoting at the cost of organismal fitness (Sandler et al 1959; Lyon 1986; Safronova and Chubykin 2013; Lindholm et al 2016). Additive genetic variants can also be preserved under intra-locus sexual antagonism, where genes that are beneficial to one sex impose detrimental effects on the other (Foerster et al 2007; Van Doorn 2009; Innocenti and Morrow 2010).…”

Section: Introductionmentioning

confidence: 99%

“…specific genes) involved in dominance effects or rare variants that show main effects on reproductive traits (e.g. Christians et al 2000; Safronova and Chubykin 2013; Kim et al 2017; Knief et al 2017). As an extreme example, a balanced lethal system was identified in crested newts Triturus cristatus , where all embryos that are homozygous for chromosome 1 (about 50% of all embryos) die during development (Sims et al 1984; Grossen et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Proximate causes of infertility and embryo mortality in captive zebra finches

Pei

Forstmeier

Wang

et al. 2019

Preprint

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Some species show high rates of reproductive failure, which is puzzling because natural selection works against such failure in every generation. Hatching failure is common in both captive and wild zebra finches (Taeniopygia guttata), yet little is known about its proximate causes. Here we analyze data on reproductive performance (fate of >23,000 eggs) based on up to 14 years of breeding of four captive zebra finch populations. We find that virtually all aspects of reproductive performance are negatively affected by inbreeding (mean r = -0.117), by an early-starting, age-related decline (mean r = -0.132), and by poor early-life nutrition (mean r = - 0.058). However, these effects together explain only about 3% of the variance in infertility, offspring mortality, fecundity and fitness. In contrast, individual repeatability of different fitness components varied between 15% and 50%. As expected, we found relatively low heritability in fitness components (median: 7% of phenotypic, and 29% of individually repeatable variation). Yet, some of the heritable variation in fitness appears to be maintained by antagonistic pleiotropy (negative genetic correlations) between male fitness traits and female and offspring fitness traits. The large amount of unexplained variation suggests a potentially important role of local dominance and epistasis, including the possibility of segregating genetic incompatibilities.

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Meiotic drive in mice carrying t-complex in their genome

Cited by 7 publications

References 80 publications

Unexpected patterns of segregation distortion at a selfish supergene in the fire ant Solenopsis invicta

Unexpected patterns of segregation distortion at a selfish supergene in the fire ant Solenopsis invicta

Coevolutionary dynamics of polyandry and sex-linked meiotic drive

Proximate causes of infertility and embryo mortality in captive zebra finches

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