Meiotic Chromosome Dynamics

Kleckner, Nancy; Zhang, Liangran; Weiner, Beth M.; Zickler, Denise

doi:10.1002/9783527639991.ch19

Cited by 15 publications

(13 citation statements)

References 193 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In accord with the central role of recombination in the canonical homolog pairing and synapsis program, DSBs are essential for both processes (reviewed in Kleckner et al 2012;Baudat et al 2013). Correspondingly, in Sordaria, budding yeast and mouse, analysis of mutants showing that varying numbers of DSBs reveal direct relationships between the number of DSBs and the extents of presynaptic coalignment and/or SC formation Henderson and Keeney 2004;Kauppi et al 2013;Rockmill et al 2013).…”

Section: Recombination-mediated Homolog Pairingmentioning

confidence: 99%

“…Interestingly, however, while preferred DNA sequence regions may be involved in axis formation (e.g., a queue of locally ATrich regions in budding yeast) (Blat et al 2002), when a chromosome from one organism is introduced into another organism, it assumes the axis/loop organization of its host (Loidl et al 1995) showing that sequence features are important but are not, per se, determinative of loop size. Mitotic prophase chromosome organization may turn out to be the same as that of meiotic prophase chromosomes (Kleckner et al 2012).…”

Section: Spo11-mediated Dsbsmentioning

confidence: 99%

“…Once the pairing pro- cess is underway, telomere-led motion could help to move chromosomes out of the way of one another to permit full-length pairing. Another attractive possibility is that these motions promote resolution of entanglements (Zickler 2006;Koszul et al 2008;Storlazzi et al 2010;Kleckner et al 2012;Klutstein and Cooper 2014). Whole-chromosome entanglements, known as "interlocks," occur during the leptotene pairing process and during synapsis but are absent (and thus must be actively resolved) by the end of pachytene (reviewed in von Wettstein et al 1984;Zickler and Kleckner 1999;Storlazzi et al 2010).…”

Section: Configuration and Entanglement Resolutionmentioning

confidence: 99%

See 2 more Smart Citations

Recombination, Pairing, and Synapsis of Homologs during Meiosis

Zickler

Kleckner

2015

Cold Spring Harb Perspect Biol

Self Cite

691

828

View full text Add to dashboard Cite

Recombination is a prominent feature of meiosis in which it plays an important role in increasing genetic diversity during inheritance. Additionally, in most organisms, recombination also plays mechanical roles in chromosomal processes, most notably to mediate pairing of homologous chromosomes during prophase and, ultimately, to ensure regular segregation of homologous chromosomes when they separate at the first meiotic division. Recombinational interactions are also subject to important spatial patterning at both early and late stages. Recombination-mediated processes occur in physical and functional linkage with meiotic axial chromosome structure, with interplay in both directions, before, during, and after formation and dissolution of the synaptonemal complex (SC), a highly conserved meiosis-specific structure that links homolog axes along their lengths. These diverse processes also are integrated with recombination-independent interactions between homologous chromosomes, nonhomology-based chromosome couplings/clusterings, and diverse types of chromosome movement. This review provides an overview of these diverse processes and their interrelationships.

show abstract

Section: Recombination-mediated Homolog Pairingmentioning

confidence: 99%

Section: Spo11-mediated Dsbsmentioning

confidence: 99%

Section: Configuration and Entanglement Resolutionmentioning

confidence: 99%

See 1 more Smart Citation

Recombination, Pairing, and Synapsis of Homologs during Meiosis

Zickler

Kleckner

2015

Cold Spring Harb Perspect Biol

Self Cite

691

828

View full text Add to dashboard Cite

show abstract

“…However, connectedness of homologs at prophase can be mediated by DSB-independent pairing in diverse situations (review in 12). Moreover, while the basis for such pairing is not established, two DNA molecules can pair in a homology-dependent fashion in vitro , in the absence of aggregating agents, leading to the suggestion that DNA/DNA pairing is actually the "default option" for the in vivo situation and is specifically precluded in general by programmed features.…”

Section: Evolution Of Meiosis and The Role Of The Bouquetmentioning

confidence: 99%

“…Meiotic recombination occurs after DNA replication, with all DNA events occurring in recombination complexes that are intimately associated with the chromosome axes (6,12,82,83). Recombination is initiated at many positions along the chromosomes via programmed axis-associated double-strand breaks (DSBs).…”

Section: Crossover (Co) Interferencementioning

confidence: 99%

A few of our favorite things: Pairing, the bouquet, crossover interference and evolution of meiosis

Zickler

Kleckner

2016

Seminars in Cell & Developmental Biology

Self Cite

125

139

View full text Add to dashboard Cite

Meiosis presents many important mysteries that await elucidation. Here we discuss two such aspects. First, we consider how the current meiotic program might have evolved. We emphasize the central feature of this program: how homologous chromosomes find one another ("pair") so as to create the connections required for their regular segregation at Meiosis I. Points of emphasis include the facts that: (i) the classical "bouquet stage" is not required for initial homolog contacts in the current evolved meiotic program; and (ii) diverse observations point to commonality between molecules that mediate meiotic inter-homolog interactions and molecules that are integral to centromeres and/or to microtubule organizing centers (a.k.a. spindle pole bodies or centrosomes). Second, we provide an overview of the classical phenomenon of crossover (CO) interference in an effort to bridge the gap between description on the one hand versus logic and mechanism on the other.

show abstract

Sequence analysis of wheat subtelomeres reveals a high polymorphism among homoeologous chromosomes

Aguilar

Prieto

2020

The Plant Genome

View full text Add to dashboard Cite

Bread wheat, Triticum aestivum L., is one of the most important crops in the world. Understanding its genome organization (allohexaploid; AABBDD; 2n = 6x = 42) is essential for geneticists and plant breeders. Particularly, the knowledge of how homologous chromosomes (equivalent chromosomes from the same genome) specifically recognize each other to pair at the beginning of meiosis, the cellular process to generate gametes in sexually reproducing organisms, is fundamental for plant breeding and has a big influence on the fertility of wheat plants. Initial homologous chromosome interactions contribute to specific recognition and pairing between homologues at the onset of meiosis. Understanding the molecular basis of these critical processes can help to develop genetic tools in a breeding context to promote interspecific chromosome associations in hybrids or interspecific genetic crosses to facilitate the transfer of desirable agronomic traits from related species into a crop like wheat. The terminal regions of chromosomes, which include telomeres and subtelomeres, participate in chromosome recognition and pairing. We present a detailed molecular analysis of subtelomeres of wheat chromosome arms 1AS, 4AS, 7AS, 7BS and 7DS. Results showed a high polymorphism in the subtelomeric region among homoeologues (equivalent chromosomes from related genomes) for all the features analyzed, including genes, transposable elements, repeats, GC content, predicted CpG islands, recombination hotspots and targeted sequence motifs for relevant DNA-binding proteins. These polymorphisms might be the molecular basis for the specificity of homologous recognition and pairing in initial chromosome interactions at the beginning of meiosis in wheat. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

show abstract

Meiotic Chromosome Dynamics

Cited by 15 publications

References 193 publications

Recombination, Pairing, and Synapsis of Homologs during Meiosis

Recombination, Pairing, and Synapsis of Homologs during Meiosis

A few of our favorite things: Pairing, the bouquet, crossover interference and evolution of meiosis

Sequence analysis of wheat subtelomeres reveals a high polymorphism among homoeologous chromosomes

Contact Info

Product

Resources

About