Meio de contraste ioversol em neuroradiologia canina

Abstract

O ioversol, contraste iodado hidrossolúvel não iônico, na concentração de 320mg I/ml foi utilizado para a realização de 26 estudos neuroradiográficos contrastados (mielografias, epidurografias, e ventrículografia cerebral) em 22 cães. Devido à rápida absorção do contraste, as melhores radiografias foram obtidas nos primeiros 30 minutos. O produto ofereceu apropriadas radiopacidade, tempo de permanência, difusão e miscibilidade no líqüor, facilitando os diagnósticos, assim como mínima ocorrência de reações indesejáveis durante e após o procedimento radiológico. Apesar de terem sido utilizados para a anestesia, as associações zolazepam-tiletamina e levomepromazina; xilazina ou diazepam-tiopental sódico, nenhum paciente desenvolveu convulsões. A apresentação do ioversol em frasco arnpola foi também outra vantagem, por diminuir o desperdício e facilitar a reesterilização do excedente na autoclave.

Cardiovascular and respiratory alterations in dogs during cervical myelography using ioversol

“…This is in agreement with other findings (Ralston et al, 1989;Tudury et al, 1997), and supports that ioversol has a low epileptogenic activity. It also reinforces its indication for myelography.…”

“…Although the dogs that received an infusion of ioversol had respiratory rates statistically lower than the control group, the values remained within normal parameters (10 -30 movements/min). There were no registered occurrences of apnea (Tudury et al, 1997) or respiratory arrest (Clark, 1986;Lehmann et al, 1987) during subarachnoid infusion, which supports the claim that ioversol is safe regarding its effects on the respiratory function.…”

“…Vet. Zootec., v.65, n.4, p.1024-1032, 2013 320mgI/mL contradicts earlier reports, which observed tachycardia following the infusion of the same contrast medium (Tudury et al, 1997); and bradycardia with the use of iohexol (Lewis and Hosgood, 1992) (cisternal and lumbar injections) and iopamidol (Cox and Jakovljevic, 1986) (cisterna magna). The results obtained in this study were supported by the mean values gathered and compared from continuous monitoring of all dogs that underwent infusion of autologous CSF or ioversol.…”

“…In Canada and Europe, ioversol (240mgI/mL) is administered subarachnoidally for conventional myelography and computed tomography of the spinal column in humans (Wible et al, 1995;Drug..., 2002) and dogs (Tudury et al, 1997).…”

“…Ioversol quickly diffuses from the cisterna magna into the adjacent brain tissue, where traces can remain up to 24 hours after infusion (Jacobsen, 1992;Wible et al, 1995). Dogs undergoing myelography are subject to side effects such as tremors, fasciculations, limb withdrawal, tachycardia and apnea, as well as alterations in cerebrospinal fluid (CSF) four days after infusion (Tudury et al, 1997). Despite the side effects seen with ioversol, patient tolerance is considered high in human medicine, and its use is indicated in high risk, elderly, diabetic, heart and kidney disease patients (Benamor et al, 1989;McClennan and Bettmann, 1989).…”