Meibum lipid composition in type 2 diabetics with dry eye

Yang, Qin; Li, Bing; Sheng, Mao

doi:10.1016/j.exer.2021.108522

Cited by 11 publications

(3 citation statements)

References 38 publications

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“…Ding’s study found that insulin stimulates IHMGECs, and that glucose exposure is deleterious to them [ 30 ]. Moreover, the abnormal expression of meibum lipids was observed in T2DM patients in other research [ 9 ]. The authors suggested that these changes in meibum lipids could increase the meibum viscosity, induce periglandular inflammation, promote hyperkeratinization of the terminal ductules, and cause duct obstruction.…”

Section: Discussionmentioning

confidence: 79%

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Evaluation of meibomian gland dysfunction in type 2 diabetes with dry eye disease: a non-randomized controlled trial

Yang

Liu

et al. 2023

BMC Ophthalmol

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Background The purpose of this investigation was to evaluate the morphology and physiological function of the meibomian glands between type 2 diabetics with dry eye disease (DED) and control subjects. Doing so will help to better reveal the pathologic mechanisms of meibomian gland dysfunction (MGD) and DED in type 2 diabetes mellitus (T2DM). Methods Ninety subjects were divided into the following four groups: DM-DED group: T2DM patients with DED (n = 30); DM control group: DM patients without DED (n = 18); DED group: DED patients without DM (n = 26); and normal control group: normal subjects (n = 16). All participants administered the ocular surface disease index (OSDI) questionnaire, tear meniscus height (TMH), noninvasive Keratograph tear film break-up time (NIKBUT), Schirmer I test (SIT), corneal fluorescein staining (CFS), eyelid margin abnormality examinations, meibum quality and meibomian gland (MG) dropout evaluations. Results The percentage of MG dropout in the upper and lower lids was significantly higher in the DM-DED group than the DED group (P < 0.05 or P < 0.01). However, there was no significant difference in other MG parameters between these two groups. Oppositely, Significant difference was observed in all of MG parameters except MG dropout in the lower lids comparing DM group with normal controls (P < 0.05 or P < 0.01). While the SIT values decreased in the DM-DED group compared to the DED group (P < 0.05), no significant differences were found in the values of other tear parameters. Conclusions The higher prevalence and increased severity of MGD was found in patients with both T2DM and DED compared to those only with DED. Trial registration Chinese Clinical Trial Registry ChiCTR1800019939, date of registration December 9, 2018, prospectively registered.

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Section: Discussionmentioning

confidence: 79%

“…Written informed consent was obtained from each participant at the examination site. The eligible criteria and grouping process were reported in the previous paper [ 9 ].…”

Section: Methodsmentioning

confidence: 99%

Evaluation of meibomian gland dysfunction in type 2 diabetes with dry eye disease: a non-randomized controlled trial

Yang

Liu

et al. 2023

BMC Ophthalmol

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“…A large proportion of DM cases is characterized as type 2 DM (T2DM), which is attributed to unhealthy eating habits, obesity, and physical inactivity. 1 T2DM can lead to complications in various organs, such as the heart, 2 eyes, 3 kidneys, 4 and nervous system, 5 resulting in high financial and health burden on patients. 6 T2DM complications are difficult to diagnose at the early stages of the disease because there is a gradual increase in blood glucose levels without obvious and typical clinical symptoms.…”

Section: Introductionmentioning

confidence: 99%

Implications of lysyl oxidase-like protein 3 expression in the periodontium of diabetic rats

et al. 2022

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Implications of lysyl oxidaselike protein 3 expression in the periodontium of diabetic rats Objectives: Diabetes has been strongly associated with periodontal diseases. The periodontal ligament (PDL) has an abundant extracellular matrix (ECM). Lysyl oxidases (LOXs) are closely associated with various diseases caused by abnormal ECM functions, however, the role of LOXs in periodontal diseases induced by diabetes remains unclear. Methodology: In this study, 8-week-old Zucker diabetic fatty rats were used to establish a type 2 diabetes mellitus (T2DM) model. After 9 and 16 weeks, hematoxylin and eosin (H&E), Masson's trichrome, and immunohistochemical staining were performed. Results: After 9 weeks, loose collagen fibers were found in the interradicular area of the diabetic group, in opposition to the control group.There were no significant differences in LOX expression between the diabetic and control groups (p>0.05). However, after 16 weeks, the diabetic group presented a disordered arrangement of the PDL, showing decreased collagen content and significantly increased lysyl oxidase-like protein 3 (LOXL3) expression when compared with the control group (p<0.05). This suggests that LOXL3 plays a significant role in periodontal histopathological changes in diabetic rats. Conclusion: Our study showed elevated LOXL3 expression in the PDL of diabetic rats after 16 weeks, suggesting that LOXL3 may be involved in the occurrence and development of periodontal histopathological changes in diabetic rats. LOXL3 could be further used as an indicator for the early diagnosis of diabetic periodontitis in T2DM patients in clinical settings.

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Inhibition of Gli1 suppressed hyperglycemia-induced meibomian gland dysfunction by promoting pparγ expression

Zou

Wang

Zhang

et al. 2022

Biomedicine & Pharmacotherapy

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Meibum lipid composition in type 2 diabetics with dry eye

Cited by 11 publications

References 38 publications

Evaluation of meibomian gland dysfunction in type 2 diabetes with dry eye disease: a non-randomized controlled trial

Evaluation of meibomian gland dysfunction in type 2 diabetes with dry eye disease: a non-randomized controlled trial

Implications of lysyl oxidase-like protein 3 expression in the periodontium of diabetic rats

Inhibition of Gli1 suppressed hyperglycemia-induced meibomian gland dysfunction by promoting pparγ expression

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