Meibomian gland dysfunction

Driver, Paul J.; Lemp, Michael A.

doi:10.1016/s0039-6257(96)80064-6

Cited by 266 publications

(208 citation statements)

References 139 publications

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“…These changes in individuals with CAIS are consistent with our hypothesis that the androgen control of lipid production in the meibomian gland is mediated, at least in part, through the binding to intranuclear androgen receptors. In addition, given that a disruption in the quality of meibomian gland lipids may promote tear film instability and evaporation, 7,9,11,14,15 Our finding that androgen receptor dysfunction is paralleled by a change in the lipid patterns of meibomian gland secretions might have been predicted based on our earlier observations and those of others.…”

Section: Commentsupporting

confidence: 56%

Complete Androgen Insensitivity Syndrome

Sullivan

Evans²,

Cermák³

et al. 2002

Arch Ophthalmol

119

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To determine whether androgen receptors affect the fatty acid profiles of neutral and polar lipids in human meibomian gland secretions.Methods: Meibomian gland secretion samples were obtained from both eyes of (1) women with complete androgen insensitivity syndrome, a condition characterized by dysfunctional androgen receptors, and (2) agematched female and male controls. Samples were processed for high-performance liquid chromatography, mass spectrometry, or both and for analysis of the mass spectra of neutral and polar lipid fatty acid fragment ions by 3 different methods.Results: Androgen receptor dysfunction is associated with significant alterations in the appearance of nu-merous molecular species in the neutral and polar lipid fractions of meibomian gland secretions. The ability to detect these differences, and to assess their nature and extent, was facilitated by the use of several analytic approaches. Sex-related differences exist in the expression of a variety of neutral and, especially, polar fatty acid products in meibomian gland secretions.Conclusions: Androgens exert a significant effect on neutral and polar lipids in human meibomian gland secretions, and these hormonal effects may be mediated through androgen receptors.

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Section: Commentsupporting

confidence: 56%

Complete Androgen Insensitivity Syndrome

Sullivan

Evans²,

Cermák³

et al. 2002

Arch Ophthalmol

119

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“…The number of meiboman glands is higher in upper eyelid (approximately 30-40 meibomian glands) when compared to lower eyelid (approximately 20-30 meibomian glands) [10] . In addition, meibomian glands are thinner and longer in upper eyelids than in lower eyelids, at the same time squamous blepharitis and posterior lid margin rounding were more in upper eyelid [6,9] .…”

Section: Resultsmentioning

confidence: 83%

Are There Any Difference Between Primary and Multiple Operated Chalazion According to Age, Gender or Lesion Location?

İlhan

Yılmazbaş²

2017

International Journal of Ophthalmic Research

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45 and 54.5, percent of female were 55 and 45.5 in primary chalazion (PC) and multiple operated chalazion (MOC) groups, respectively. The mean age was 42.0 ± 19.4 years and 36.6 ± 15.8 years in two groups. The percent of right eye laterality were 72.5 and 52.4, percent of left eye laterality were 27.5 and 47.6 in PC and MOC groups, respectively. The percent of upper eyelid location were 60 and 40, percent of lower eyelid location were 40 and 60 in PC and MOC groups, respectively. When compared two groups according to age, gender, chalazion laterality and location, there were no statistically significant differences (p values were 0.302, 0.475, 0.119 and 0.259 respectively). CONCLUSION: Factors such as age, gender and site of chalazion are similar in both PC and MOC groups. INTRODUCTIONChalazion is one of the most prevalent eye diseases. Non-infectious lipogranulomatous inflammation related to blocked meibomian gland orifices causes chalazion [1,2] . Painless swelling, ptosis, narrow eyelid aperture and astigmatism are chalazion related clinical findings [3] . If lesion does not resolve with warm compress, several invasive treatment options such as intralesional steroid injection or surgical drainage can be performed [4] .After treatment, recurrent chalazion can occur in same or another eyelid. In generally, this condition is related to chronic blepharitis and meibomian gland dysfunction. Meibomian glands are placed in tarsal plates of eyelids and produce lipid layer of preocular tear film [5] . Normally, meibomian glands have different anatomical properties in MATERIALS AND METHODS:Daily chalazion operation lists of Ulucanlar Eye Training and Education Hospital were examined retrospectively. Adult patients who missing medical records and all pediatric population were excluded. Forty patients who underwent chalazion surgery for first time and 22 patients who underwent multiple chalazion surgery were included. Two groups were compared according to age, gender, and site of chalazion. RESULTS: This study consisted of 30 males and 32 females. The mean age of patients was 40.1 ± 18.2 years. The percent of male were

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“…Obstruction of the meibomian ducts can then cause accumulation of meibum, which may lead to inflammation and bacterial colonization. [26][27][28][29] These conditions may cause clinically apparent ocular discomfort to prosthetic eye wearers. Inflammatory cytokines, such as interleukin (IL)-1, IL-6, IL-8, IL-12, and epidermal growth factor, have been reported to be increased in patients with meibomian gland dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Short-term effects of topical cyclosporine A 0.05% (Restasis) in long-standing prosthetic eye wearers: a pilot study

Han

Yoon

Jang

2014

Eye

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Purpose Long-standing prosthetic eye wearing induces ocular surface inflammation. We investigated the short-term effects of topical cyclosporine A 0.05% (Restasis) in patients with ocular discomfort resulting from long-standing prosthetic eye wearing. Methods This was a prospective, interventional case series. Patients who were unilateral prosthetic eye wearers over a period of 5 years were enrolled at a single institution from March to July 2013. The subjects were instructed to instill topical cyclosporine A 0.05% twice per day. Measurements were made pre-treatment and after 1 and 3 months of treatment. Outcome measures were the ocular symptom score, the lid margin abnormality score, the Schirmer test, and the tear meniscus amount, using Fourier-domain optical coherence tomography. Results In total, 20 consecutive patients (mean age: 60.1 years, 8 males, 12 females) were included. Ocular symptoms were improved after treatment for 1 month in all patients (ocular symptom score pre-treatment 76.83 vs 46.75 after treatment; Po0.001). There was no statistically significant difference in lid margin abnormality score or tear meniscus amount. The Schirmer test results were improved after treatment for 3 months (pre-and after treatment, 6.70 vs 11.40; Po0.001). Conclusions Topical cyclosporine A 0.05% showed a satisfactory effect in long-standing prosthetic eye wearers. Ocular symptoms were markedly relieved in all subjects after treatment for 1 month.

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Meibomian gland dysfunction

Cited by 266 publications

References 139 publications

Complete Androgen Insensitivity Syndrome

Complete Androgen Insensitivity Syndrome

Are There Any Difference Between Primary and Multiple Operated Chalazion According to Age, Gender or Lesion Location?

Short-term effects of topical cyclosporine A 0.05% (Restasis) in long-standing prosthetic eye wearers: a pilot study

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