Meibomian gland atrophy with duration of Sjogren’s syndrome in adult females

Noh, Sung Rae; Chung, J. N.; Lee, Jeong Min; Seo, Kyoung Yul; Koh, Kyungmin

doi:10.1007/s10792-021-02013-7

Cited by 6 publications

(5 citation statements)

References 51 publications

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“…7,9 Meibomian gland dysfunction is an important cause of dry eye. 25 A study indicated that a longer duration of pSS was associated with more severe meibomian gland atrophy after controlling for age, 26 partially explaining the higher proportion of dry eyes in pSS patients with a long disease duration reported in this study. Furthermore, pSS patients with a long disease duration had higher elasticity scores of parotid glands and a more severe degree of parotid main ductal stenosis.…”

Section: Glandular Injury In Pssmentioning

confidence: 52%

Disease Duration Affects the Clinical Phenotype of Primary Sjögren Syndrome

Zhang,

Yang,

Chen

et al. 2024

J Clin Rheumatol

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Objectives To investigate the impact of disease duration on clinical phenotypes in Chinese patients with primary Sjögren syndrome (pSS) and examine the correlation between clinical phenotypes and onset age, age at diagnosis, and disease duration. Methods Data from 952 patients diagnosed with pSS in China between January 2013 and March 2022 were analyzed based on medical records. Patients were categorized into 3 groups based on disease duration: short (<5 years), moderate (≥5 and <10 years), and long (≥10 years) group. Clinical characteristics were compared among the 3 groups, and pSS patients with a long disease duration were compared with the other patients after matching age at diagnosis and age at onset. Results Among the patients, 20.4% had a disease duration over 10 years. After matching for age at onset and age at diagnosis, pSS patients with a long disease duration exhibited a significantly higher prevalence of dry mouth (p <0.001), dry eyes (p <0.001), fatigue (p <0.001), arthralgia (p <0.001), and dental caries (p <0.001) and higher rates of anti-Sjögren syndrome A (p < 0.05), anti-Ro52 (p < 0.05), and anti-SSB (p < 0.05) positivity than their control groups, with prevalence increasing with disease duration (p trend < 0.001). However, no differences were noted in the prevalence of interstitial lung disease and leukopenia between different disease duration groups after matching for age at onset, although differences were shown when matching for age at diagnosis. Conclusion Longer disease duration in pSS patients correlates with increased prevalence of sicca symptoms, fatigue, and arthralgia and higher positivity of autoantibodies associated with pSS. However, the prevalence of interstitial lung disease and leukopenia did not correlate with disease duration after matching for age at onset.

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Section: Glandular Injury In Pssmentioning

confidence: 52%

Disease Duration Affects the Clinical Phenotype of Primary Sjögren Syndrome

Zhang,

Yang,

Chen

et al. 2024

J Clin Rheumatol

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“…In fact, the work of Zhang [ 14 ] suggests a lower sensitivity of SGUS in early phases of disease, while others demonstrate stability of gland abnormalities over time [ 19 ]. In other studies, disease duration correlates with the degree of gland atrophy [ 20 ]. Our data show more frequent diagnostic SGUS in longer disease duration.…”

Section: Discussionmentioning

confidence: 92%

The Role of Major Salivary Gland Ultrasound in the Diagnostic Workup of Sicca Syndrome: A Large Single-Centre Study

Vallifuoco,

Falsetti,

Bardelli

et al. 2024

Tomography

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(1) Objective: To determine the diagnostic accuracy of major salivary gland ultrasonography (SGUS) in primary Sjogren’s syndrome (SS), we used the Outcome Measures in Rheumatology Clinical Trials (OMERACT) scoring system on a large single-centre cohort of patients with sicca syndrome. (2) Method: We retrospectively collected the clinical, imaging and serological data of all the patients referred with a suspicion of SS who underwent SGUS and minor salivary glands biopsy. (3) Results: A total of 132 patients were included. The SGUS scores were correlated between the two sides (p < 0.001). The diagnostic cut-off for SS (AUROC: 0.7408) was 6 for the SGUS-global sum (sensitivity: 32.43%; specificity: 96.84%). The cut-off with the highest specificity for SS diagnosis was 7. In the patients with a final diagnosis of SS, the mean SGUS score was significantly higher (p < 0.001) than that of the non-SS patients (3.73 vs. 1.32 for the SGUS-global sum). A significant correlation was demonstrated between the SGUS scores and final SS diagnosis (p < 0.001), biopsy positivity (p < 0.001), ANA positivity (p = 0.016), Ro-SSA positivity (p = 0.01), and gland fibrosis (p = 0.02). (4) Conclusions: SGUS, using the OMERACT scoring system, has moderate sensitivity and high specificity for the diagnosis of SS. The scoring showed a strong and direct correlation with all the clinical hallmarks of SS diagnosis, such as the positivity of a labial salivary gland biopsy, ANA and Ro-SSA statuses, and salivary gland fibrosis. Because of its high specificity, a SGUS-global score > 6 could be therefore employed for the diagnosis of SS in the case of ANA negativity or the unavailability of a biopsy.

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“…The participants were asked to open their eyes wide and look straight, and a single ophthalmologist (KK) measured the time taken for a black spot or line to appear on the cornea. Interval between last blink to the first sign of tear film rupture was recorded as TBUT [ 45 , 46 ]. While measuring TBUT, the CFS score (0–9) was also evaluated [ 47 ].…”

Section: Methodsmentioning

confidence: 99%

Intense pulsed-light treatment improves objective optical quality in patients with meibomian gland dysfunction

2023

Self Cite

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Background To evaluate changes in objective optical quality following intense pulsed light (IPL) treatment combined with meibomian gland (MG) expression (MGX) in patients with MG dysfunction (MGD). Methods This retrospective cross-sectional study included MGD-related dry eye disease (DED) patients who received IPL treatment between March and December 2021 at Kim’s Eye Hospital, Seoul, Republic of Korea. Each patient underwent four sessions of IPL treatment using Lumenis M22 (Lumenis Ltd., Yokneam, Israel) and MGX at three-week intervals. Results This study included 90 eyes from 45 patients with MGD. The mean age was 52.3 ± 16.1 years (range, 20–75 years), and 53.3% (24/45) of patients were female. Compared with the baseline, all clinical symptoms and signs significantly improved after IPL treatment combined with MGX. All optical quality parameters obtained with an optical quality analysis system (OQAS: Visiometrics, Castelldefels, Spain) have improved significantly over the baseline (p < 0.001). Conclusions In patients with MGD, IPL treatment combined with MGX improved the objective optical quality and clinical signs and symptoms of DED.

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Meibomian gland atrophy with duration of Sjogren’s syndrome in adult females

Cited by 6 publications

References 51 publications

Disease Duration Affects the Clinical Phenotype of Primary Sjögren Syndrome

Disease Duration Affects the Clinical Phenotype of Primary Sjögren Syndrome

The Role of Major Salivary Gland Ultrasound in the Diagnostic Workup of Sicca Syndrome: A Large Single-Centre Study

Intense pulsed-light treatment improves objective optical quality in patients with meibomian gland dysfunction

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