Mehrlagige Amnionmembran-Transplantation bei therapieresistentem Hornhautulkus - eine prospektive Studie des Zustandes von Hornhaut und Amnionmembran im Verlauf 123

Souza, Renate Ferreira de; Hofmann-Rummelt, Carmen; Kruse, Friedrich E.; Seitz, Berthold

doi:10.1055/s-2001-17134

Cited by 17 publications

(7 citation statements)

References 14 publications

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“…; Fereira de Souza et al. ). An exception is the series by Shukla (), who reported on 50 patients; however, these authors used non‐preserved amniotic membranes and did not give any information regarding BCVA or recurrence.…”

Section: Discussionmentioning

confidence: 98%

“…Regarding corneal re‐epithelialization, success rates varied from 19% to 91% (Fereira de Souza et al. ; Nubile et al. ; Berguiga et al.…”

Section: Discussionmentioning

confidence: 99%

“…), and improved visual acuity was found in 18–90% of patients (Fereira de Souza et al. ; Dogru et al. ; Prabhasawat et al.…”

Section: Discussionmentioning

confidence: 99%

“…Successful epithelialization of the corneal surface following the use of mostly glycerine-preserved mono-or multilayer human amniotic membranes has been observed in several clinical investigations. These membranes were applied in patients who suffered from various diseases of the ocular surface: corneal epithelial defects (Prabhasawat et al 2001;Letko et al 2001), ulcers (Kruse et al 1999;Chen et al 2000;Fereira de Souza et al 2001;Hanada et al 2001;Dogru et al 2003;Chen et al 2006;Nubile et al 2011;Iakimento et al 2013;Berguiga et al 2013) or perforation (Chen et al 2006;M€ uller et al 2009). Regarding corneal re-epithelialization, success rates varied from 19% to 91% (Fereira de Souza et al 2001;Nubile et al 2011;Berguiga et al 2013), and improved visual acuity was found in 18-90% of patients (Fereira de Souza et al 2001;Dogru et al 2003;Prabhasawat et al 2001).…”

Section: Discussionmentioning

confidence: 99%

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Long‐term efficacy of glycerine‐processed amniotic membrane transplantation in patients with corneal ulcer

Uhlig¹,

Frings²,

Rohloff³

et al. 2015

Acta Ophthalmologica

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ABSTRACT.Purpose: The aim of this study was to determine the long-term treatment efficacy of glycerine-preserved human amniotic membrane transplantation in patients suffering from corneal ulcers. Methods: This was a retrospective, non-controlled, monocentric analysis. Included were patients with corneal ulcers that were non-responsive to ointment or contact lenses and had been treated by amniotic membrane transplantation with either the overlay or sandwich procedure. Analysis parameters were visual acuity before and following treatment, recurrence rate and subjective comfort at the last follow-up. Results: Of the 371 amniotic membrane transplantations that were conducted, 135 surgical treatments in 108 patients (51.9% male, 48.1% female; mean age 63.7 years) met the inclusion criteria. In total, 99 overlay and 36 multilayer amniotic membrane transplantations were performed. The follow-up period was 47.5 AE 66.7 weeks (mean AE SD). The recurrence rate at the last follow-up was 47.8% with overlay membranes and 51.8% with the sandwich technique. There was no significant change in best-corrected visual acuity following treatment with overlays (p = 0.219) or sandwich procedure (p = 0.703). At the last follow-up, 72.1% (overlay) and 78.3% (sandwich) of the patients reported either no pain or increased comfort. Conclusion: The recurrence rates and changes in visual acuity following overlay or sandwich amniotic membrane transplantation in patients suffering from corneal ulcer were lower than reported elsewhere in the literature. More than half of the patients profited from each of the amniotic membrane transplantation techniques with respect to recurrence and postoperative comfort.

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Section: Discussionmentioning

confidence: 98%

“…Regarding corneal re‐epithelialization, success rates varied from 19% to 91% (Fereira de Souza et al. ; Nubile et al. ; Berguiga et al.…”

Section: Discussionmentioning

confidence: 99%

“…), and improved visual acuity was found in 18–90% of patients (Fereira de Souza et al. ; Dogru et al. ; Prabhasawat et al.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Long‐term efficacy of glycerine‐processed amniotic membrane transplantation in patients with corneal ulcer

Uhlig¹,

Frings²,

Rohloff³

et al. 2015

Acta Ophthalmologica

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“…These methods are described elsewhere. 34 All patients received ofloxacin drops and a bandage contact lens at the completion of the procedure. The contact lens and sutures were left in place for 4 weeks unless they were found to be loose.…”

Section: Methodsmentioning

confidence: 99%

Corneal calcification after amniotic membrane transplantation

Anderson

Souza²,

Hofmann-Rummelt³

et al. 2003

British Journal of Ophthalmology

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Background/aims: Amniotic membrane transplantation (AMT) has become well established as a treatment for chronic epithelial defects, conjunctival reconstruction, and partial limbal cell deficiency. The aim of this study was to describe cases of corneal calcification following AMT and to search for risk factors that might predispose to this unusual finding. Methods: Details of 117 AMTs on 93 corneas of 91 patients with a follow up period of at least 1 month performed since 1999 were collected prospectively. In those with calcification clinical photographs were studied and the medical records retrospectively examined. Results: 15 calcifications in 117 AMTs (12.8%) were identified, occurring 3-17 (median 6.1) weeks after AMT, during a follow up period of 4-151 (median 25) weeks. Overall epithelial healing rate was 83%. Calcification covered a surface area between 0.7-40.5 mm 2 maximum size with varied morphology. The primary diagnosis was diverse. Risk factors included the use of phosphate eye drops and pre-existing calcification in the operative or other eye. No patient with a "patch" AMT developed calcification. Conclusions: Corneal calcification occurs after some cases of AMT. A common risk factor was the postoperative use of phosphate containing eye drops.

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Histopathology and Ultrastructure of Human Corneas After Amniotic Membrane Transplantation

Seitz¹

2006

Arch Ophthalmol

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Mehrlagige Amnionmembran-Transplantation bei therapieresistentem Hornhautulkus - eine prospektive Studie des Zustandes von Hornhaut und Amnionmembran im Verlauf 123

Cited by 17 publications

References 14 publications

Long‐term efficacy of glycerine‐processed amniotic membrane transplantation in patients with corneal ulcer

Long‐term efficacy of glycerine‐processed amniotic membrane transplantation in patients with corneal ulcer

Corneal calcification after amniotic membrane transplantation

Histopathology and Ultrastructure of Human Corneas After Amniotic Membrane Transplantation

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