Megavoltage Therapy in Patients with Aneurysmal Bone Cysts

Marks, Richard D.; Scruggs, Hugh J.; Wallace, Keene M.; Fenn, Jimmy O.

doi:10.1148/118.2.421

Cited by 33 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results observed with radiation therapy are similar to those obtained with surgery, achieving adequate local control of the disease in 75-100% of patients [56].…”

Section: Aneurysmatic Bone Cystsupporting

confidence: 67%

Radiation therapy for the treatment of benign vascular, skeletal and soft tissue diseases

et al. 2008

View full text Add to dashboard Cite

The concept of radiation therapy for the treatment of benign diseases refers to the use of moderate to high-energy ionising radiation as part of the treatment of non-malignant, but not necessarily harmless, diseases. The usefulness of radiation therapy, based on the anti-inflammatory properties of ionising radiation, has long been known. Apart from the treatment of intracranial benign tumours, such as meningiomas and neurinomas, the prevention of cardiovascular restenosis or treatment of skeletal degenerative diseases are, without doubt, the main fields of action for radiation therapy in benign conditions. Nonetheless, many other non-cancer entities may benefit from ionising radiation therapy treatment. The purpose of this review is to highlight and update indications for treatment with radiation therapy in benign conditions, focusing on skeletal degenerative processes, vascular conditions and soft tissue diseases.

show abstract

“…Results observed with radiation therapy are similar to those obtained with surgery, achieving adequate local control of the disease in 75-100% of patients [56].…”

Section: Aneurysmatic Bone Cystsupporting

confidence: 67%

Radiation therapy for the treatment of benign vascular, skeletal and soft tissue diseases

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Although the adverse effects of radiotherapy should be taken into consideration, it is possible that modern advances in radiotherapy have rendered this treatment safer than previously considered [21,25]. In a 2015 case series of 12 patients treated with radiotherapy for ABC, Zhu et al reported no recurrence and no complications at final follow-up [26].…”

Section: Radiotherapymentioning

confidence: 99%

“…However, complications from radiotherapy include chronic effects that can impair function and secondary malignancies, which have prevented its adoption into widespread practice. Feigenberg and Marks et al argue that instances of radiation induced complications reported in the literature were in part the result of outdated techniques and technology [21,25]. To our knowledge, there exists no evidence with longterm follow-up regarding modern adjuvant radiation therapy in the treatment of ABCs.…”

Section: Adjuvant Radiotherapymentioning

confidence: 99%

Current management of aneurysmal bone cysts

Park

Yang

Sheppard

et al. 2016

Curr Rev Musculoskelet Med

184

259

View full text Add to dashboard Cite

Aneurysmal bone cysts (ABCs) are benign bone lesions arising predominantly in the pediatric population that can cause local pain, swelling, and pathologic fracture. Primary lesions, which constitute roughly two thirds of all ABCs, are thought to be neoplastic in nature, with one third of ABCs arising secondary to other tumors. Diagnosis is made with various imaging modalities, which exhibit characteristic features such as Bfluid-fluid levels,^although biopsy is critical, as telangiectatic osteosarcoma cannot be excluded based on imaging alone. Currently, the standard of care and most widely employed treatment is intralesional curettage. However, tumor recurrence with curettage alone is common and has driven some to propose a multitude of adjuvants with varying efficacy and risk profiles. Historically, therapies such as en bloc resection or radiation therapy were utilized as an alternative to decrease the recurrence rate, but these therapies imposed high morbidity. As a result, modern techniques now seek to simultaneously reduce morbidity and recurrence, the pursuit of which has produced preliminary study into minimally invasive percutaneous treatments and medical management.

show abstract

“…The underlying tumor may disrupt and/or alter local vasculature leading to formation of an aneurysmal bone cyst 16 . Transformation of aneurysmal bone cysts into malignant neoplasms has been described in humans 18,20,25–27 . Both radiation therapy and surgical curettage have been reported to induce transformation of aneurysmal bone cysts into sarcomas.…”

Section: Discussionmentioning

confidence: 99%