Megastudies: A New Approach to Reducing Vaccine Hesitation Worldwide

Abstract

Vaccine hesitancy is a considerable obstacle to achieving vaccine protection worldwide. There needs to be more evidence-based research for interventions for vaccine hesitancy. Existing effectiveness evaluations are limited to one particular hypothesis, and no studies have compared the effectiveness of different interventions. A megastudy takes a large-scale, multi-intervention, uniform participant and the same evaluation criteria approach to evaluate many interventions simultaneously and find the most effective ones. Therefore, megastudies can help us find the most effective interventions for vaccine hesitancy. Additionally, considering the complex causes of vaccine hesitancy, we design interventions that involve social factors in megastudies. Lastly, quality control and justice are critical issues for megastudies in the future.

Perceptions of COVID-19 Vaccines: Protective Shields or Threatening Risks? A Descriptive Exploratory Study among the Italian Population

“…Nevertheless, infectious diseases are an ever-present threat to humans. Therefore, high vaccination coverage rates are necessary to reduce the spread of life-threatening diseases, helping people of all ages live longer and healthier [ 2 ]. Recently, on 30 January 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a public health emergency of international concern [ 3 ].…”

COVID-19 Vaccine Hesitancy in Italian Adults with Marfan Syndrome: Insights from a Secondary Analysis of a Cross-Sectional Study

“…COVID-19 vaccine hesitancy has become a significant public health concern, as widespread vaccination is crucial for ending the COVID-19 pandemic and returning to normalcy [1][2][3][4][5]. COVID-19 vaccine hesitancy refers to the reluctance or unwillingness of individuals to receive a COVID-19 vaccine, despite its availability and recommendation by healthcare professionals and public health organizations [6].…”

“…COVID-19 vaccine hesitancy refers to the reluctance or unwillingness of individuals to receive a COVID-19 vaccine, despite its availability and recommendation by healthcare professionals and public health organizations [6]. Vaccine hesitancy can have several dimensions, including concerns about the safety and effectiveness of the vaccine, mistrust of the healthcare system or government, religious or cultural beliefs, fear of side effects, and misinformation or misconceptions about the vaccine [1][2][3][4][5][6]. Although vaccine hesitancy was described in several groups of patients [7][8][9], the general public [5,10], and in several countries [7][8][9][10][11], the available information on COVID-19 vaccine hesitancy is currently lacking in specific subgroups of patients, as per adults with Marfan syndrome (MFS) [12].…”