Megastigmane and abscisic acid glycosides from the leaves of Laurus nobilis L.

Le, Duc Dat; Ngo, Viet Duc; Luyen, Bui Thi Thuy; Oanh, Ha Van; Jang, Hyun Jae; Hương, Trần Thu; Kim, Young Ho; Thao, Nguyen Phuong

doi:10.1016/j.phytol.2019.06.011

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…Furthermore, we found published reports showing that, besides the terpenic compounds, several other phytochemical constituents were isolated from Laurus nobilis L. including alkaloids, phenolics and megastigmanes (De Marino et al 2004 ). Within this latter group, we noticed that the recently identified laurusides 1–7 (Duc Dat et al 2019 ) are an almost unexplored class of laurel-derived compounds (Fig. 2 ).…”

Section: Resultsmentioning

confidence: 88%

“…Six out of nine of these ligands belong to the family of laurusides described by Duc Dat et al (Duc Dat et al 2019 ), natural products extracted by Laurus nobilis L. able to inhibit, in cell, the lipopolysaccharide (LPS)-induced nitric oxide release.…”

Section: Resultsmentioning

confidence: 99%

“…bay laurel ( Laurus nobilis L.) (Alessi et al 2018 ), as a source of potential anti-COVID-19 natural products, studied in silico for their abilities to bind M pro , the main protease of SARS-CoV-2 (Jin et al 2020 ). They were also studied for their toxicity with a particular attention paid to laurusides, a scarcely explored class of compounds from laurel that could disclose interesting biological activities (Duc Dat et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Lower COVID-19 mortality in Italian forested areas suggests immunoprotection by Mediterranean plants

Roviello

2020

Environ Chem Lett

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The COVID-19 pandemic has induced dramatic effects on the population of the industrialized north of Italy, whereas it has not heavily affected inhabitants of the southern regions. This might be explained in part by human exposure to high levels of fine particulate matter (PM) in the air of northern Italy, thus exacerbating the mortality. Since trees mitigate air pollution by intercepting PM onto plant surfaces and bolster the human immune system by emitting bioactive volatile organic compounds (VOCs), we hypothesize a protective role of evergreen forested areas in southern Italy. We compared the mortality rate due to COVID-19, the death number, the positivity rate and the forest coverage per capita in various Italian regions. Hectares of forest per capita and prevalence of deciduous versus evergreen forestal species were also estimated. In silico docking studies of potentially protective compounds found in Laurus nobilis L., a typical Mediterranean plant, were performed to search for potential antivirals. We found that the pandemic's severity was generally lower in southern regions, especially those with more than 0.3 hectares of forest per capita. The lowest mortality rates were found in southern Italy, mainly in regions like Molise (0.007%) and Basilicata (0.005%) where the forest per capita ratio is higher than 0.5 Ha/person. Our findings suggest that evergreen Mediterranean forests and shrubland plants could have protected the southern population by emission of immunomodulating VOCs and provision of dietary sources of bioactive compounds. Moreover, in silico studies revealed a potential anti-COVID-19 activity in laurusides, which are unexplored glycosides from bay laurel. Overall, our results highlight the importance of nature conservation and applications to the search for natural antivirals.

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Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lower COVID-19 mortality in Italian forested areas suggests immunoprotection by Mediterranean plants

Roviello

2020

Environ Chem Lett

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“…The influenza viruses and the coronavirus SARS-CoV-2 are only some examples of the many viral pathogens that can be managed using foods with antiviral properties [ 43 ] including bay laurel ( Laurus nobilis ), a culinary Mediterranean plant whose extracts were found to be active against highly pathogenic human coronaviruses such as SARS-CoV [ 44 ]. Remarkably, bay laurel contains specific glycosides known as laurusides [ 45 ] that were hypothesized to be inhibitors of SARS-CoV-2 M pro [ 46 ] and, among these, laurusides 1 and 2 (herein below indicated as L01 and L02) showed high scores of the M pro binding affinity [ 46 ], and enzyme inhibition as predicted by Molinspiration software ( Table S1 ). Chemically, L01 and L02 are diastereomers showing comparable properties, as reported in Table S1 .…”

Section: Introductionmentioning

confidence: 99%

Interaction of Laurusides 1 and 2 with the 3C-like Protease (Mpro) from Wild-Type and Omicron Variant of SARS-CoV-2: A Molecular Dynamics Study

Autiero

Roviello

2023

IJMS

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Laurus nobilis (bay laurel) is a natural source of biological compounds, and some of its extracts and phytocompounds are also endowed with antiviral activity toward the family of the severe acute respiratory syndrome (SARS)-associated β-coronaviruses. Some glycosidic laurel compounds such as laurusides were proposed as inhibitors of important protein targets of SARS-CoV-2, which clearly recalls their potential as anti-COVID-19 drugs. Due to the frequent genomic variations of the β-coronaviruses and the consequent importance of evaluating a new drug candidate with respect to the variants of the target β-coronavirus, we decided to investigate at an atomistic level the molecular interactions of the potential laurel-derived drugs laurusides 1 and 2 (L01 and L02, respectively) toward a well-conserved and crucial target, the 3C-like protease (Mpro), using the enzymes of both the wild-type of SARS-CoV-2 and of the more recent Omicron variant. Thus, we performed molecular dynamic (MD) simulations of laurusides—SARS-CoV-2 protease complexes to deepen the knowledge on the stability of the interaction and compare the effects of the targeting among the two genomic variants. We found that the Omicron mutation does not significantly impact the lauruside binding and that L02 connects more stably with respect to L01 in the complexes from both variants, even though both compounds prevalently interact within the same binding pocket. Although purely in silico, the current study highlights the potential role of bay laurel phytocompounds in the antiviral and specifically anti-coronavirus research and shows their potential binding toward Mpro, corroborating the important commitment of bay laurel as functional food and disclosing novel scenarios of lauruside-based antiviral therapies.

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Laurel, Laurus nobilis L.: a review of its botany, traditional uses, phytochemistry and pharmacology

et al. 2022

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Megastigmane and abscisic acid glycosides from the leaves of Laurus nobilis L.

Cited by 7 publications

References 17 publications

Lower COVID-19 mortality in Italian forested areas suggests immunoprotection by Mediterranean plants

Lower COVID-19 mortality in Italian forested areas suggests immunoprotection by Mediterranean plants

Interaction of Laurusides 1 and 2 with the 3C-like Protease (Mpro) from Wild-Type and Omicron Variant of SARS-CoV-2: A Molecular Dynamics Study

Laurel, Laurus nobilis L.: a review of its botany, traditional uses, phytochemistry and pharmacology

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