1954
DOI: 10.1016/s0140-6736(54)92647-1
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Megaloblastic Anæmia Due to Phenytoin Sodium

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Cited by 25 publications
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“…Two cases of megaloblastic anaemia occurring in epileptics who had been taking phenobarbitone and phenytoin were reported by Badenoch (1954), who suggested that the anticonvulsants-might have played a part in the production of the anaemia. Other cases have been reported by Hawkins and Meynell (1954), Chalmers and Boheimer (1954), and Rhind and Varadi (1954).…”
mentioning
confidence: 71%
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“…Two cases of megaloblastic anaemia occurring in epileptics who had been taking phenobarbitone and phenytoin were reported by Badenoch (1954), who suggested that the anticonvulsants-might have played a part in the production of the anaemia. Other cases have been reported by Hawkins and Meynell (1954), Chalmers and Boheimer (1954), and Rhind and Varadi (1954).…”
mentioning
confidence: 71%
“…In only one case, that of Rhind and Varadi, has there been evidence of malabsorption, and even this was inconclusive. The normal vitamin B12 serum levels in those cases in which this has been determined (Badenoch, 1954;Chalmers and Boheimer, 1954;Rhind and Varadi, 1954), and the excellent response to folic acid, suggest that this anaemia is essentially a folic acid deficiency, whatever its precise mechanism. It is extremely difficult to produce a folic acid deficiency in the experimental animal, but, in man, megaloblasts have occasionally been found in the bone marrow in cases of acute leukaemia treated by aminopterin (Stickney, 1952).…”
Section: Discussionmentioning
confidence: 91%
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“…Since that time I have had three other examples of anaemia of a similar character resulting from phenytoin, though one of these has also received primidone, and my experience adds nothing, except numbers, to that of Gydell andothers (Hawkins andMeynell, 1954, 1956;Chalmers and Boheimer, 1954;Rhind and Varadi, 1954;Webster, 1954;Berlyne et al, 1955;Ryan and Forshaw, 1955). In a few of these recorded examples extensive investigation has shown that the serum B12 level and the absorption of folic acid were normal; all have responded to folic acid by mouth and only four to vitamin B12 by injection, though in the case of two of the latter the withdrawal of phenytoin may have been responsible for the improvement (Webster, 1954; Ryan and Forshaw, 1955) whilst one other (Chalmers and Boheimer, 1954) may have had coincidental pernicious anaemia.…”
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confidence: 89%
“…In [953 primidone, one gramme per day, was commenced, and in 1954 to this was added phenytoin and :\leynell, 1954 .. Rhind and Varadi, 1954Berlyne, Levene and :\IcClashan, '955 Vaishnava, 1955Hurwitz, 1956Girdwood, 1956 ----- Girdwood and Lenman, 1956 I Phenobarbitone…”
Section: Case Reportmentioning
confidence: 99%