Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated With the Presence of Lymph Node Metastases, Vascular Invasion and Lower Overall Survival
Abstract:Megalin (LRP2) is a rapidly recycling multiligand endocytic receptor, primarily expressed in polarized epithelial cells. Despite megalin could promote tumor growth and invasiveness through several mechanisms, it has been understudied in the field of molecular oncology so far. The present study aimed to evaluate the impact of megalin expression in oral squamous cell carcinoma (OSCC) on disease progression. Megalin expression was evaluated immunohistochemically in 63 OSCC specimens. Data obtained were retrospect… Show more
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