Megakaryocytes and atherosclerosis

Kristensen, Steen Dalby; Martin, John F.

doi:10.1042/cs0820353

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…CSF pattern causes thrombus and therefore distal embolism or myocardial infarction may occur 32,34,35. High MPV levels have been reported in connection with acute coronary syndrome as well 31. The high MPV levels observed in this study might support the suggestion that thrombus formation, distal embolism, and acute vascular events may occur in CSF.…”

Section: Discussionsupporting

confidence: 75%

Focusing on a complete blood cell parameter: mean platelet volume levels may be a predictor of coronary slow flow

Yılmaz

Dağlı

Uku

et al. 2017

VHRM

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BackgroundThe relationship between increased mean platelet volume (MPV) and atherosclerosis is well known. In the present study, MPV in patients with coronary slow flow (CSF) and in cases with normal coronary anatomy (NCA) was investigated and compared with the aim of identifying the relationship between CSF and MPV.Patients and methodsWe studied 40 patients previously determined via coronary angiography as having NCA and 40 patients with CSF in the coronary blood stream, as identified by thrombolysis in myocardial infarction square. Thus, a total of 80 patients from the Elaziğ Education and Research Hospital (Elaziğ, Turkey) were included in the present study retrospectively and laboratory and anamnesis information was scanned into their files. The relationship between MPV and CSF was studied.ResultsMPV levels were observed to be significantly higher in the CSF group compared to the NCA group (10.05±1.3 and 8.6±0.6, p<0.001). In receiver operating characteristics analyses, it was determined that an MPV >9.05 measured in CSF patients at application had a predictive specificity of 77.5% and sensitivity of 77.5% for CSF (area under the curve: 0.825, 95% confidence interval [CI]: 0.726–0.924, p<0.0001). It was found that MPV level was an independent predictor of CSF (β=−600, p<0.001, 95% CI: −0.383 to −0.176).ConclusionMPV is increased in patients with CSF when compared to patients with NCA. This finding supports the fact that MPV could be a predictor of CSF.

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Section: Discussionsupporting

confidence: 75%

Focusing on a complete blood cell parameter: mean platelet volume levels may be a predictor of coronary slow flow

Yılmaz

Dağlı

Uku

et al. 2017

VHRM

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“…We therefore measured platelet count and size in patients with stable angina and ACS. Since atherosclerosis itself may influence the bone marrow megakaryocytes before platelet production [25,26], we also assessed the extent of CAD in all patients by coronary angiography.…”

Section: Discussionmentioning

confidence: 99%

The relationship between platelet indices and clinical features of coronary artery disease

et al. 2013

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“…It has been suggested that an increase in MK ploidy may be also associated with the production of large, hyper-reactive platelets [ 181 and that this change may have a role in both the thrombotic [24] and atherosclerotic [25] elements of ischaemic heart disease. In this article we will review the evidence supporting this claim.…”

Section: Introductionmentioning

confidence: 99%

The regulation of megakaryocyte polyploidization and its implications for coronary artery occlusion

Martin¹

1993

Eur J Clin Investigation

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Abstract. Polyploidization is a distinctive feature of megakaryocyte differentiation. The physiological meaning and the regulation of this process are obscure. Megakaryocyte ploidy varies in normal biology and in disease. Here we review the evidence suggesting that ploidy changes may have a role in the determination of platelet reactivity and in the aetiology of coronary artery occlusion. We also present a hypothesis that may serve as a framework to explore the regulation of megakaryocyte polyploidization at the molecular level and also may provide a rational basis to explain the occurrence of ploidy changes in ischaemic heart disease.

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Megakaryocytes and atherosclerosis

Cited by 4 publications

References 15 publications

Focusing on a complete blood cell parameter: mean platelet volume levels may be a predictor of coronary slow flow

Focusing on a complete blood cell parameter: mean platelet volume levels may be a predictor of coronary slow flow

The relationship between platelet indices and clinical features of coronary artery disease

The regulation of megakaryocyte polyploidization and its implications for coronary artery occlusion

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