Megadose Methylprednisolone (MDMP) Treatment in a Patient with Autoimmune Hemolytic Anemia (AIHA) Resistant to Conventional Corticosteroid Administration: A Case Report

Abstract

A female in the Netherlands with severe autoimmune hemolytic anemia (AIHA) was treated with conventional corticosteroid (2 mg/kg/d in divided doses) and blood transfusions for 18 months without improvement. The presented patient responded to megadose methylprednisolone (MDMP) 30 mg/kg/d for 3 d, followed by 20 mg/kg for 4 d, and subsequently 10, 5, 2, and 1 mg/kg/d each for 1 week.Conflict of interest:None declared.

Quality Assessment of Brands of Prednisolone (5 Mg) Tablets Marketed in Abuja Metropolis of Nigeria

“…Its IUPAC name is disodium [2-(8S, 9S, 10R, 11S, 13S, 14S, 17R)-11,17-dihydroxy-10, 13-dimethyl-3oxo- 7, 8, 9, 11, 12, 14, 15, 16-octahydro-6H-cyclopenta[α] phenanthren-17-yl]-2-oxoethyl phosphate, with C 21 H 28 O 5 as its molecular formula, while its molecular weight is 360.45. The therapeutic indications for prednisolone include endocrine, rheumatic, dermatologic, ophthalmic, respiratory, hematologic, neoplastic, gastrointestinal, and nervous system disorders, allergic conditions, edematous states, tuberculous meningitis, trichinosis, and as a substance of abuse for weight gain due to fluid retention side effects (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27).…”