Megacolon and Autonomic Neuropathy in Diabetic Rats

Nelsc, J. S.; Lacy, Paul E.; Hirshberg, G. E.

doi:10.1097/00005072-197605000-00079

Cited by 31 publications

(12 citation statements)

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“…While increased peristaltic activity, rapid transit and reduced intestinal tone have been observed in diabetic diarrhoea [ 1,4], another study has shown delayed transit through the ileum and still other studies have reported no change in intestinal tone in this condition [5], Recently, the absence of a postprandial response has been indicated in diabetic patients suffering from constipation [ 6], Animal models have been used in rela tively few studies on the gastro-intestinal function in diabetes mellitus. Megacolon has been demonstrated in streptozotocin-diabetic rats [7], In addition, impairment in the adrenergic and cholinergic innervation of the colon [8] has been reported in experi mentally diabetic animals.…”

Section: Introductionmentioning

confidence: 99%

Decreased Gastro-intestinal Responses to Certain Agonists in Streptozotocin- and Alloxan-Diabetic Rats in vitro

Altan¹,

Yildizoğlu²,

Öztürk³

1987

Pharmacology

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In this study, the β-adrenergic, muscarinic and serotonergic receptor activities were investigated in alloxan- and streptozotocin-diabetic rats using duodenum, ileum and gastric fundus strips as assay organs. In addition, the effect of manganese chloride on the duodenum of normal and diabetic rats was studied to understand whether it affects the gastro-intestinal adenylate cyclase activity. The results obtained in this study suggest that no significant changes occur in the gastro-intestinal muscarinic receptor and adenylate cyclase activities due to experimental diabetes. Nevertheless, the experiments performed on the rat duodenum and gastric fundus strips with salbutamol and serotonin showed that the β-adrenergic and serotonergic receptor activities of the gastro-intestinal tract decreased significantly in alloxan- and streptozotocin-induced diabetes. The results obtained seem to show that the gastro-intestinal complication(s) of the diabetes were related to the reduction(s) of the β-adrenergic and/or serotonergic receptor activities.

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Section: Introductionmentioning

confidence: 99%

Decreased Gastro-intestinal Responses to Certain Agonists in Streptozotocin- and Alloxan-Diabetic Rats in vitro

Altan¹,

Yildizoğlu²,

Öztürk³

1987

Pharmacology

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“…similar changes to human diabetics (NELSON et al, 1976;SCOTT and ELLIS,1980). In such diabetic animal models, defective cholinergic neuromuscular transmission in the myenteric plexus of the distal colon is revealed by electrical field stimulation (NOwAK et al, 1986).…”

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confidence: 57%

Acetylcholine and substance P responsiveness of intestinal smooth muscles in streptozotocin diabetic rats.

1988

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We found previously that in in vitro tube form preparations of isolated intestine of streptozotocin (STZ) diabetic rats, frequency of spontaneous intraluminal pressure waves was significantly reduced in duodenum when compared with normal controls. In order to elucidate further the diabetic intestinal disorders, we examined the frequency and amplitude of spontaneous length changes and contractile responses to acetylcholine (ACh) and substance P (sP) in isolated intestinal segments of normal and experimental diabetic rats. In comparison with normal controls, we could confirm the significantly decreased frequency of spontaneous length changes in isolated longitudinal and circular muscle preparations of diabetic duodenum (1 month after STZ injection). Furthermore, amplitude of spontaneous length changes was significantly decreased in circular muscle preparations of duodenum, jejunum, and ileum but not in colon nor in longitudinal muscle preparations. Doseresponse curves revealed that both ACh and sP responses were significantly decreased in longitudinal and circular muscle preparations of diabetic duodenum, jejunum, and ileum but not in colon. Mechanisms of reduced contractility of diabetic intestinal smooth muscle in response to ACh and sP were discussed.

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“…Delayed small intestinal transit and megacolon have been demonstrated in streptozotocin treated diabetic rats. [161,162] Several different factors have been implicated in this pathogenic process. Hyperglycemic activation of the polyol pathway leading to accumulation of sorbitol and potential changes in the NAD: NADH ratio may cause direct neuronal damage and/or decreased nerve blood flow.…”

Section: Discussionmentioning

confidence: 99%

“…Delayed small intestinal transit and megacolon have been demonstrated in streptozotocin treated diabetic rats. [10][11] Oxidative stress plays a vital role in contributing to neural and vascular complications. [12] Dietary supplements of antioxidants are required to achieve an increase in antioxidant status which may diminish oxidative stress associated with diabetes mellitus.…”

mentioning

confidence: 99%

Pharmacodynamic Interaction of Momordica Charantia With Oral Hypoglycemic Agents in Diabetes Induced Gastropathy

Rai¹

2017

WJPPS

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Megacolon and Autonomic Neuropathy in Diabetic Rats

Cited by 31 publications

References 0 publications

Decreased Gastro-intestinal Responses to Certain Agonists in Streptozotocin- and Alloxan-Diabetic Rats in vitro

Decreased Gastro-intestinal Responses to Certain Agonists in Streptozotocin- and Alloxan-Diabetic Rats in vitro

Acetylcholine and substance P responsiveness of intestinal smooth muscles in streptozotocin diabetic rats.

Pharmacodynamic Interaction of Momordica Charantia With Oral Hypoglycemic Agents in Diabetes Induced Gastropathy

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