Mefenamic acid and flufenamic acid compared with aspirin and phenylbutazone in rheumatoid arthritis.

Abstract

The only advantage of the Davis pipette is that patients can take their own sample without the need to attend a clinic or to see a doctor; it might therefore be possible to reach a larger proportion of the population at risk. However, the low rate of detection would necessitate repeated screenings of each patient at fairly short time-intervals, and although the initial response might be good, it could prove difficult to persuade women to take repeated samples, especially in view of the complaints from the clinics participating in this survey. Like Macgregor and her colleagues, we think that the cytopipette is not an appropriate instrument for urban-community-screening programmes. ConclusionsOur results leave us in no doubt that when a cervical cytology specimen is taken by a doctor the Ayre smear is a more effective method than the Davis cytopipette in the detection of malignancy. The Davis method has been extensively used in Denmark (Bredahl et al., 1965) al., 1962, 1963) and subsequently both have been found useful in patients with rheumatoid arthritis (Coodley, 1963;Young, 1963

Autoimmune Haemolytic Anaemia and Mefenamic Acid Therapy

“…In clinical. trials Cahill, Hill, Jessop, and Kendall (1965), Barnardo, Currey, Mason, Fox, and Weatherall (1966), and Myles, Bacon, and Williams (1967) have suggested that it is of comparable value to aspirin and phenylbutazone, but has a very low incidence of upper intestinal side-effects, which are common with the majority of drugs used in chronic rheumatic diseases. In view of the pogsible relation between mefenamic acid and haemolytic anaemia long-term therapy with this drug should be undertaken with caution and the patients should be watched carefully for evidence of haemolysis.…”

Mefenamic acid in rheumatoid arthritis.

“…Barnardo, Currey, Mason, Fox, and Weatherall (1966) showed that mefenamic acid was a comparable analgesic to aspirin and phenylbutazone. Young (1963) showed that mefenamic acid was comparable to oxyphenbutazone.…”

“…Five patients had side-effects with both mefenamic Discussion The preliminary assessment indicated that mefenamic acid was a superior analgesic to indomethacin and showed fewer side-effects. Barnardo, Currey, Mason, Fox, and Weatherall (1966) showed that mefenamic acid was a comparable analgesic to aspirin and phenylbutazone. Young (1963) showed that mefenamic acid was comparable to oxyphenbutazone.…”

Flufenamic acid in rheumatoid arthritis.

“…Prednisone proved more effective in reducing the number of joints involved and in increasing the strength of grip; it also markedly reduced the average ESR whereas flufenamic acid did not influence this measurement. Barnardo, Currey, Mason, Fox, and Weatherall (1966) compared mefenamic acid and flufenamic acid with aspirin and phenylbutazone in female outpatients with rheumatoid arthritis; phenylbutazone was preferred slightly but not significantly more often than any other drug and flufenamic acid was least popular, but again not significantly. The design of this trial provided for adjustment of dosage to the need of individual patients and equipotent daily doses of the trial drugs were estimated as 2 -4 g. for aspirin, 0 * 33 g. for phenylbutazone, 1 * 7 g. for mefenamic acid, and 0-67 g. for flufenamic acid.…”