“…Major problems with barrier methods (female condom, vaginal ring, diaphragm) include compliance problems, improper use, and higher failure rates [51,82]. Synthetic estrogen and progestins may influence depressive and physical symptoms in depressed women [4,43,60,72,81]. Research suggests that women with major depression, schizophrenia, bipolar disorder, and cognitive impairment may be at increased risk for breast and cervical cancer [6,9,11,20,25,40,56,58].…”