Meesmann Corneal Dystrophy Associated With Epithelial Basement Membrane and Posterior Polymorphous Corneal Dystrophies

Cremona, Federico Andrés; Ghosheh, Faris R.; Laibson, Peter R.; Rapuano, Christopher J.; Cohen, Elisabeth J.

doi:10.1097/ico.0b013e31815c18fa

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…Frequently, the disease is asymptomatic until adulthood when it may cause mild irritation, foreing body sensation, blurred vision, photophobia, and tearing. Frequently, patients do not tolerate wearing contact lenses that may cause a direct trauma to the corneal epithelium (Burns, ; Cremona et al, ).…”

Section: Clinical Featuresmentioning

confidence: 99%

Pathophysiology of Corneal Dystrophies: From Cellular Genetic Alteration to Clinical Findings

Sacchetti

Macchi

Tiezzi

et al. 2015

Journal Cellular Physiology

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Corneal dystrophies are a heterogeneous group of bilateral, inherited, rare diseases characterized by slowly progressive corneal opacities, that lead to visual impairment. Most of them have an autosomal dominant pattern of inheritance with variable expressivity, but new mutations have been described. Many corneal dystrophies have been genetically characterized and the specific gene mutations identified, such as for the epithelial-stromal TGFBI dystrophies. Current classification systems identified four main groups of corneal dystrophies based on clinical, histologic, and genetic information. Diagnosis is performed during a routine ophthalmic examination that shows typical cellular abnormalities of the corneal epithelium, stroma, or endothelium. Disease progression should be carefully monitored to decide the proper clinical management. The treatment of corneal dystrophies is variable, depending on symptoms, clinical course, severity, and type of dystrophy. Management aimed to reduce symptoms and to improve vision, includes different surgical approaches. Novel cellular and genetic therapeutic approaches are under evaluation. J. Cell. Physiol. 231: 261-269, 2016. © 2015 Wiley Periodicals, Inc.

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Section: Clinical Featuresmentioning

confidence: 99%

Pathophysiology of Corneal Dystrophies: From Cellular Genetic Alteration to Clinical Findings

Sacchetti

Macchi

Tiezzi

et al. 2015

Journal Cellular Physiology

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“…Descriptions of this kind of rare combinations can be found in the literature. 10 – 12 Considering 3-year follow-up of presented patient's disease, it is rather unlikely to search for dystrophic background, mostly due to regression in patient's clinical state that is untypical for dystrophic intercourse. In comparison with available confocal description of ICE syndrome, where authors describe presence of epithelioid cells within endothelium, hyperreflectivity of cells nuclei, sac-like blisters, and ruptured blisters, revealed no such cell abnormalities in the presented report.…”

Section: Discussionmentioning

confidence: 99%

Atypical Regressive Corneal Endothelial Cysts in Long-Term Confocal Follow-Up

et al. 2015

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Corneal endothelium is formed of 1 layer of mitochondria-rich cubic cells whose main role is to maintain corneal transparency. Corneal endothelial disorders represent group of both inherited and noninherited and may affect proper vision.A 36-year-old male patient with suspicion of corneal endothelial dystrophy underwent visual acuity, intraocular pressure, the basic slit-lamp examination, anterior segment optical coherence tomography (AS-OCT) (Visante, Carl Zeiss Meditec, Dublin, CA), and corneal confocal microscopy in vivo (Rostock Cornea Module, Heidelberg Engineering Retina Tomograph III, Heidelberg, Germany). During the 3-year observation the patient reported symptoms mainly in the right eye. Slit-lamp examination revealed endothelial changes, much more pronounced in the right eye. Examination by the AS-OCT Visante showed hyperreflective dots within the right corneal endothelium. In order to assess endothelial cell morphology, analysis using corneal confocal microscopy in vivo was performed. Scans revealed presence of single endothelial deposits and severe cell changes of different morphology in both eyes. In the right eye, less pronounced changes of the polymorphic structure—polygonal guttas in different stages, linear and branched loss with “nuclear-like” formations and accompanying sediments. In the left eye, severe homomorphous polygonal “guttas-like” changes with “nuclear-like” formations were observed. Endothelial cysts’ features were dynamically changing during follow-up time with different effects on the patient's clinical state.Corneal confocal microscopy allows accurate imaging of the endothelial cells and their detailed characteristics. Structural changes within the endothelial cells are not always proportional to visual acuity and slit-lamp image. The presented case is an example of an unusual corneal endothelial syndrome with probably nondystrophic background due to observed dynamic state with regressive tendency.

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Anterior Corneal Dystrophies

Laibson¹

2011

Cornea

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Meesmann Corneal Dystrophy Associated With Epithelial Basement Membrane and Posterior Polymorphous Corneal Dystrophies

Abstract: This case is reported because of the unusual occurrence of Meesmann corneal dystrophy with other corneal dystrophies.

Cited by 6 publications

References 25 publications

Pathophysiology of Corneal Dystrophies: From Cellular Genetic Alteration to Clinical Findings

Pathophysiology of Corneal Dystrophies: From Cellular Genetic Alteration to Clinical Findings

Atypical Regressive Corneal Endothelial Cysts in Long-Term Confocal Follow-Up

Anterior Corneal Dystrophies

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