Medulloepithelioma of the optic nerve with intradural extension - report of two cases and a review of the literature

Chidambaram, B.; Santosh, Vani; Balasubramaniam, V.

doi:10.1007/s003810050527

Cited by 31 publications

(43 citation statements)

References 16 publications

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“…1,6,10,11,21,22,28,31,38,40,44) On the other hand, intraorbital, 7,8,15,30) peripheral, 26) and cauda equina 22) medulloepitheliomas have a much less malignant course and even those treated primarily or only by enucleation tend not to recur for a long time. 7,15,19,27) Extracranial and intracranial medulloepitheliomas have similar histological features, 8,30) and the great difference in the prognosis remains to be elucidated. In addition, the differences in the biological characteristics and behaviors of these neoplasms are unexplained.…”

Section: Discussionmentioning

confidence: 99%

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Cerebral Medulloepithelioma With Long Survival -Case Report-

Matsumoto

Horiuchi

Sato

et al. 2007

Neurol. Med. Chir.(Tokyo)

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An 8-year-old boy presented with a rare cerebral medulloepithelioma manifesting as headache, nausea, and vomiting. Neuroimaging demonstrated a mass containing a cyst in the left frontal lobe. Gross total resection of the tumor with a 1-cm margin was performed under intraoperative monitoring. The histological diagnosis was medulloepithelioma. Stereotactic radiotherapy (total dose 20 Gy) was given to the brain up to 1 cm from the surgical margin. Follow-up neuroimaging 5 years later showed no signs of recurrence. He now attends junior high school, with normal mental and physiological development. Medulloepitheliomas are rare, highly malignant embryonal tumors of the central nervous system. Combined gross total tumor resection and radiotherapy are recommended to obtain the most favorable outcome.

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Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][42][43][44][45] Although most medulloepitheliomas manifest in the first decade of life, 1,11,13,15,22,25,28,31,39,40,…”

Section: Discussionmentioning

confidence: 99%

Cerebral Medulloepithelioma With Long Survival -Case Report-

Matsumoto

Horiuchi

Sato

et al. 2007

Neurol. Med. Chir.(Tokyo)

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“…[20][21][22] This is not surprising when one considers that the embryonic neuroepithelium that lines the invaginated optic vesicle is continuous with that lining the cavities of the optic nerve and the forebrain early in embryonic development. A medulloepithelioma can thus arise from any point along this pathway.…”

Section: Medulloepitheliomasmentioning

confidence: 99%

Primary tumours of the optic nerve and its sheath

Miller

2004

Eye

193

140

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“…1 In human beings, a cockatiel, and a llama, the neoplastic cells are most consistently positive for vimentin and NSE, but vary in GFAP staining. 1,2,9 In the presently described tumor, pancytokeratin exhibited positive immunoreactivity while vimentin and synaptophysin were negative, supporting a diagnosis of adenocarcinoma. Retrobulbar adenocarcinomas in bird species can arise from the periocular glands, including the zygomatic gland, harderian gland, or other lacrimal glands.…”

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confidence: 91%

Retrobulbar adenocarcinoma in an Amazon parrot (Amazona autumnalis)

Watson

Murdock

Cazzini³

et al. 2013

J VET Diagn Invest

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Abstract. Retrobulbar neoplasms are not common in mammals and are even more infrequently seen in nonmammalian species. The current report describes a retrobulbar mass creating exophthalmia and neurologic signs in a red-lored Amazon parrot (Amazona autumnalis). A 27-year-old female parrot presented for a 3-day history of anorexia and a 2-week history of periocular soft tissue swelling and exophthalmia of the right eye. Physical examination revealed 9% dehydration and right eye exophthalmia with inability to retropulse the globe. A fine-needle aspirate was performed, and cytologic evaluation revealed necrotic debris with scattered clusters of epithelial cells, moderate numbers of macrophages, and few heterophils. Given the possibility of neoplasia and paucity of treatment options, the owners elected euthanasia and submitted the body for necropsy. A large, fluctuant, friable, red, retrobulbar mass with multiple areas of hemorrhage, on cut surface, was noted at necropsy. Histologically, the mass was composed of neoplastic, cuboidal to columnar epithelial cells, forming rosette-like glandular structures, admixed with abundant necrotic debris. The neoplastic cells were strongly positive for cytokeratin (AE1/AE3) by immunohistochemistry. Based on histopathology and immunohistochemistry, the mass was diagnosed as an adenocarcinoma.

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Medulloepithelioma of the optic nerve with intradural extension - report of two cases and a review of the literature

Abstract: Medulloepithelioma is an uncommon tumour. Among the various sites of origin the optic nerve is rare. We report here two cases of medulloepithelioma of the optic nerve that had extended intradurally into the cranial cavity. A review of the published cases is also given.

Cited by 31 publications

References 16 publications

Cerebral Medulloepithelioma With Long Survival -Case Report-

Cerebral Medulloepithelioma With Long Survival -Case Report-

Primary tumours of the optic nerve and its sheath

Retrobulbar adenocarcinoma in an Amazon parrot (Amazona autumnalis)

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